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Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.

  • Fernández-Lebrero A, Jiménez-Balado J, García-Escobar G, Contador J, Estraguès-Gázquez I, Peraferrer-Montesinos L, Manero-Borràs RM, Gramegna LL, Viles M, Campello AR, Ortiz-Romero P, de Diego M, Del Campo M, Torres-Torronteras J, Jiménez-Moyano E, Blasco-Forniés H, Suárez-Calvet M, Ois A, Puig-Pijoan A, Navalpotro-Gómez I. 

    Plasma p-tau217 detects Alzheimer's disease co-pathology in cerebral amyloid angiopathy: Comparison to CSF biomarkers in the ANGMAR cohort

    Alzheimer's & Dementia
    Abstract

    Introduction: Cerebral amyloid angiopathy (CAA) frequently co-occurs with Alzheimer's disease (AD), generating mixed vascular-neurodegenerative phenotypes. Plasma phosphorylated tau (p-tau)217 is a...

  • Martínez-Flores R, Zapata LP, Del Campo Milan M, Blasco-Forniés H, Jiménez-Moyano E, Torres-Torronteras J, Suárez-Calvet M, Ibáñez A, Martín-Sobrino I, Falgàs N, Grau-Rivera O, Cristi-Montero C, Perone C, Supèr H.

    Attentionally directed oculomotor training produces disease-stage-dependent effects on plasma tau, cognition, and oculomotor signatures in patients with mild cognitive impairment

    Geroscience
    Abstract

    Attentionally directed oculomotor training may engage circuits implicated in gamma-band modulation and early Alzheimer's disease (AD) pathophysiology, yet its effects across mild cognitive impairment...

  • Bellomo G, Vermunt L, In 't Veld S, Doecke JD, Hok-A-Hin YS, Veverová K, Houtkamp IM, Alcolea D, Halbgebauer S, Quesada C, Mattsson N, Martinez-Castillo M, López-Martínez MJ, Rábano A, Boonkamp L, Fowler C, Fortea J, Gaetani L, Toja A, Pijnenburg Y, Lemstra A, van der Flier WM, Sánchez-Juan P, Hort J, Otto M, Anderl-Staub S, Sieben A, de Viel B, Engelborghs S, Hansson O, Masters C, Lleó A, Parnetti L, Teunissen CE, Del Campo M.

    Plasma proteome profiling identified biomarkers for the differential diagnosis and molecular staging of neurodegenerative dementias

    Nature Aging
    Abstract

    Blood-based biomarkers are emerging as scalable tools for the diagnosis and monitoring of neurodegenerative diseases, but markers enabling differential diagnosis across major dementias remain limited...

  • Contador J, Pozzi FE, Sánchez-Benavides G, Fernández-Arcos A, Lantero-Rodríguez J, Montoliu-Gaya L, Minguillon C, Fauria K, González-Escalante A, Ortiz-Romero P, Blasco-Forniés H, de Diego-Osaba M, Jiménez Moyano E, Quijano-Rubio C, Kollmorgen G, Le Bastard N, Nadal A, Vanmechelen E, Jeromin A, Torres-Torronteras J, Ashton NJ, Zetterberg H, Blennow K, Gispert JD, Molinuevo JL, Del Campo M, Grau-Rivera O, Suárez-Calvet M; β-AARC Study collaborators.

    Detecting amyloid-β pathology in subjective cognitive decline using plasma and CSF biomarkers

    EBioMedicine
    Abstract

    Background: Subjective cognitive decline (SCD) may represent an early stage of Alzheimer's disease (AD), but biomarker studies in this population are limited. Therefore, we compared the performance of...

  • Suárez-Calvet M, Salvadó G, de Fortuny BB, Del Campo M. 

    Blood biomarkers for Alzheimer's disease: from detection to decisions

    Lancet
  • Blujdea ER, van Bokhoven P, Martino-Adami PV, Marshe VS, Vromen EM, Hok-A-Hin YS, Boiten WA, Irwin DJ, Chen-Plotkin AS, Lemstra AW, Pijnenburg Y, van der Flier WM, Peters O, Hellmann-Regen J, Priller J, Schneider A, Wiltfang J, Jessen F, Düzel E, Buerger K, Perneczky R, Teipel S, Laske C, Brosseron F; DELCODE Consortium; Del Campo M, Wijdeven R, Visser PJ, Tijms BM, De Jager PL, Ramirez A, Teunissen CE, Vermunt L.

    Microglia protein profiles in CSF across Alzheimer's disease clinical stages

    Nature Aging
    Abstract

    Microglia are implicated in the progression of Alzheimer's disease (AD) pathology from its earliest stages, suggesting that cerebrospinal fluid (CSF) microglia profiling across clinical AD stages can...

  • Bolsewig K, Bellomo G, Hok-A-Hin YS, Al Idrissi I, Vermunt L, Lleó A, Alcolea D, Sieben A, Engelborghs S, Simonsen AH, Hasselbalch SG, Bech S, Morrema THJ, Hoozemans JJM, Bol JGJM, van Alphen J, Gaetani L, Chiasserini D, Paolini Paoletti F, Parnetti L, Kang S, Lee YG, Jeon S, Lee A, Jeon S, Ye BS, Del Campo Milán M, van der Flier WM, van de Berg WDJ, Lemstra AW, Willemse EAJ, Teunissen CE

    A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders

    Nature Medicine
    Abstract

    Accurate diagnosis of dementia with Lewy bodies (DLB) remains challenging, with misdiagnosis potentially leading to harmful treatment decisions. DOPA decarboxylase (DDC) shows promise as a...

  • Caviedes A, Cabral-Miranda F, Orellana P, Hernández H, Henríquez F, Gonzalez-Gomez R, Pizarro M, Migeot J, Ochoa-Rosales C, Gonzalez-Silva C, Marin-Diaz N, Coronel-Oliveros C, Santamaría-García H, Carmona D, García AM, Slachevsky A, Singleton A, Qi AY, Lawlor B, Miller B, Dhooge C, Pantazis C, Udeh-Momoh CT, Aguillón D, Matallana DL, Zimmer ER, Resende EPF, Farina FR, Cabello F, Lopera F, Zetterberg H, Avila-Funes JA, Acosta-Uribe J, Possin KL, Kosik KS, Hu K, Takada LT, de Oliveira MO, Maito MA, Suárez-Calvet M, Godoy ME, Behrens MI, Parra MA, Del Campo M, Bruno M, Gelvez N, Pozo-Castro N, Cochran JN, Custodio N, Ortega R, Santibanez R, de la Cruz R, Montesinos R, McDonagh S, Bandres-Ciga S, Javandel S, Brucki SMD, Pina-Escudero SD, Valcour V, Li Z, Yokoyama JS, Ibañez A, Duran-Aniotz C;

    Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America

    Nature Aging
    Abstract

    Dementia diagnosis increasingly relies on blood-based biomarkers, yet their performance in diverse populations remains insufficiently characterized. Latin America, with substantial genetic and...

  • Hok-A-Hin YS, Bongers B, Bolsewig K, Boonkamp L, Ruiters DN, Lemstra AW, van der Flier WM, Pijnenburg YAL, Del Campo M, Teunissen CE

    Development and validation of a novel panel of CSF biomarkers for Alzheimer's disease

    Alzheimer's Research & Therapy
    Abstract

    Background: Using proximity extension proteomic arrays (PEA), we previously identified a nine-biomarker CSF protein panel reflecting different biological processes dysregulated in Alzheimer´s disease...

  • Doecke JD, Bellomo G, Vermunt L, Alcolea D, Halbgebauer S, In 't Veld S, Mattsson-Carlgren N, Veverova K, Fowler CJ, Boonkamp L, Houtkamp IM, Koel-Simmerlink M, Verberk IMW, Gaetani L, Toja A, Wojdała AL, Fortea J, Pijnenburg Y, Lemstra A, van der Flier W, Hort J, Otto M, Hansson O, Parnetti L, Masters CL, Lleó A, González-Escalante A, Contador J, Suárez-Calvet M, Fernández-Lebrero A, Puig-Pijoan A, Ortiz-Romero P, Jiménez-Moyano E, Minguillón C, Del Campo M, Teunissen C

    Diagnostic performance of plasma Aβ42/40 ratio, p-tau181, GFAP, and NfL along the continuum of Alzheimer's disease and non-AD dementias: An international multi-center study

    Alzheimer's & Dementia
    Abstract

    Introduction: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aβ42/40) may have diagnostic and prognostic value...