Artículos sobre Alzheimer
Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.
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Carmona R, Roldán G, Fernández-Rueda JL, Navarro A, Peña-Chilet M; CSVS Crowdsourcing Group; Dopazo J, López-López D.
The Spanish Polygenic Score reference distribution: a resource for personalized medicine
European Journal of Human GeneticsAbstractHere we present the Polygenic Score (PGS) distributions for 3124 common diseases and quantitative traits observed in the Spanish population. To achieve so, the genomes and exomes of 2190 unrelated...
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Alessiani M, Bonura A, Iaccarino G, Rossi SS, Mangiardi M, Bravi MC, Pezzella FR, de Rubeis G, Pampana E, Anticoli S.
Safety and efficacy of mechanical thrombectomy in distal medium vessel occlusions: Experience and real-world data from an Italian stroke hub centre
Journal of stroke and cerebrovascular diseasesAbstractBackground and purpose: Distal-medium vessel occlusions (DMVOs) contribute to approximately 25-40 % of cases of ischemic stroke. Intravenous thrombolysis (IVT) achieved a complete recanalization in...
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Cumplido-Mayoral I, Sánchez-Benavides G, Vilor-Tejedor N, López-Martos D, Brugulat-Serrat A, Milà-Alomà M, Falcon C, Cacciaglia R, Minguillón C, Fauria K, Kollmorgen G, Quijano-Rubio C, Molinuevo JL, Grau-Rivera O, Suárez-Calvet M, Vilaplana V, Gispert JD
Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers.
Molecular PsychiatryAbstractMagnetic resonance Imaging (MRI)-derived brain-age prediction is a promising biomarker of biological brain aging. Accelerated brain aging has been found in Alzheimer's disease (AD) and other...
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Palmqvist S, Warmenhoven N, Anastasi F, Pilotto A, Janelidze S, Tideman P, Stomrud E, Mattsson-Carlgren N, Smith R, Ossenkoppele R, Tan K, Dittrich A, Skoog I, Zetterberg H, Quaresima V, Tolassi C, Höglund K, Brugnoni D, Puig-Pijoan A, Fernández-Lebrero A, Contador J, Padovani A, Monane M, Verghese PB, Braunstein JB, Kern S, Blennow K, Ashton NJ, Suárez-Calvet M, Hansson O.
Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform
Nature MedicineAbstractGlobal implementation of blood tests for Alzheimer's disease (AD) would be facilitated by easily scalable, cost-effective and accurate tests. In the present study, we evaluated plasma phospho-tau217...
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Toccaceli Blasi M, Raffaele F, Belvisi D, Buscarnera S, Bruno G, Fabbrini G, Canevelli M.
Frailty and hospital outcomes among patients with neurological disorders
Neurological SciencesAbstractIntroduction: Patients with neurological disorders, particularly those who are chronologically and biologically older, may display highly varied clinical courses and trajectories. The present study...
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Palpatzis E, Akinci M, Garcia-Prat M, Blennow K, Zetterberg H, Quijano-Rubio C, Kollmorgen G, Wild N, Gispert JD, Suárez-Calvet M, Grau-Rivera O, Fauria K, Brugulat-Serrat A, Sanchez-Benavides G, Arenaza-Urquijo EM; ALFA stydy
Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes
NeurologyAbstractBackground and objectives: The prevalence and impact of stressful life events (SLEs) on age-related and Alzheimer disease (AD)-related pathways may depend on social determinants including gender and...
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Frisoni GB, Ribaldi F, Allali G, Bieth T, Brioschi Guevara A, Cappa S, Cipolotti L, Frederiksen KS, Georges J, Jessen F, Koch G, Masters H, Mendes AJ, Frölich L, Garibotto V, Grau-Rivera O, Pozzi FE, Religa D, Rostamzadeh A, Shallcross L, Shenkin SD, van der Flier WM, Vernooij MW, Visser LNC, Cummings JL, Scheltens P, Dubois B, Moro E, Bassetti CLA, Kivipelto M.
Brain health services for the secondary prevention of cognitive impairment and dementia: Opportunities, challenges, and the business case for existing and future facilities
The journal of prevention of Alzheimer's DiseaseAbstractA European Task Force has recently developed and published the concept and protocols for the setup of the innovative health offer of Brain Health Services for the secondary prevention of dementia and...
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Soldevila-Domenech N, Ayala-Garcia A, Barbera M, Lehtisalo J, Forcano L, Diaz-Ponce A, Zwan M, van der Flier WM, Ngandu T, Kivipelto M, Solomon A, de la Torre R.
Adherence and intensity in multimodal lifestyle-based interventions for cognitive decline prevention: state-of-the-art and future directions
Alzheimer's Research & TherapyAbstractPreventing dementia and Alzheimer's disease (AD) is a global priority. Multimodal interventions targeting several risk factors and disease mechanisms simultaneously are currently being tested...
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Sánchez-Benavides G, Iranzo A, Grau-Rivera O, Giraldo DM, Buongiorno M
Olfactory Dysfunction as a Clinical Marker of Early Glymphatic Failure in Neurodegenerative Diseases
DiagnosticsAbstractAn abnormal accumulation of misfolded proteins is a common feature shared by most neurodegenerative disorders. Olfactory dysfunction (OD) is common in the elderly population and is present in 90% of...
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Xu X, Kwon J, Yan R, Apio C, Song S, Heo G, Yang Q, Timsina J, Liu M, Budde J, Blennow K, Zetterberg H, Lleó A, Ruiz A, Molinuevo JL, Lee VM, Deming Y, Heslegrave AJ, Hohman TJ, Pastor P, Peskind ER, Albert MS, Morris JC, Park T, Cruchaga C, Sung YJ.
Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries
JAMA Netw OpenAbstractImportance: Age, sex, and apolipoprotein E (APOE) are the strongest risk factors for late-onset Alzheimer disease (AD). The role of APOE in AD varies with sex and ancestry. While the association of...
