Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Hok-A-Hin YS, Vermunt L, Peeters CFW, van der Ende EL, de Boer SCM, Meeter LH, de Houwer J, Seelaar H, van Swieten JC, Hu WT, Lleó A, Alcolea D, Engelborghs S, Sieben A, Chen-Plotkin A, Irwin DJ, van der Flier WM, Pijnenburg YAL, Teunissen CE, Del Campo M.
Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia
AbstractBackground: Diagnosis of Frontotemporal dementia (FTD) and its specific underlying neuropathologies (frontotemporal lobar degeneration; FTLD-Tau and FTLD-TDP) are challenging, and thus, fluid...
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Rodríguez-Fernández B, González-Escalante A, Genius P, E Evans T, Ortiz-Romero P, Minguillón C, Kollmorgen G, Ashton NJ, Zetterberg H, Blennow K, Gispert JD, Navarro A, Suárez-Calvet M, Sala-Vila A, Crous-Bou M, Vilor-Tejedor N.
Longitudinal association of shorter leukocyte telomere length with CSF biomarker dynamics across early Alzheimer's disease stages in at-risk individuals
EBioMedicineAbstractBackground: Short telomere length (TL), a hallmark of biological ageing, has been associated with an increased risk of Alzheimer's disease (AD), but its pathophysiological role remains unclear. This...
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Alraddadi A, Smalley JP, Alzahrani W, Saleh A, Al-Mansour F, He B, Cao TH, Jayne S, Dyer M, Hodgkinson JT, Jones DJL, Cowley SM, Macip S.
Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death
EJHaemAbstractDespite the good options for the management of Diffuse large B-cell lymphoma (DLBCL), a significant percentage of patients either do not respond to current treatments or relapse after a short time...
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Osset-Malla M, Martínez-Velasco A, Sánchez-Benavides G, Buongiorno M, de la Sierra A, Shekari M, Minguillon C, Kollmorgen G, Quijano-Rubio C, Zetterberg H, Blennow K, García DV, Suárez-Calvet M, Gispert JD, Grau-Rivera O.
Blood pressure and Alzheimer's disease biomarkers in cognitively unimpaired adults: a multicenter study
The journal of prevention of Alzheimer's DiseaseAbstractBackground: Hypertension is a modifiable risk factor for dementia, potentially influencing Alzheimer's disease (AD) pathology. Understanding this relationship is essential for developing interventions...
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Oosthoek M, Vijverberg EGB, Blujdea ER, Veld SGJGI, Avilés MP, Zsadanyi SE, Hok-A-Hin YS, Visser A, van der Flier WM, Barkhof F, Del Campo M, Schut MC, Bejanin A, Alcolea D, Teunissen CE, Vermunt L.
CHIT1 and DDAH1 levels relate to amyloid-related imaging abnormalities risk profile in Alzheimer's disease patients
Alzheimer's Research & TherapyAbstractBackground: Amyloid-related imaging abnormalities (ARIA) are a common and potentially dangerous side effect in anti-amyloid therapies, creating a need for tools to assess ARIA risk. Several patient...
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Palmqvist S, Whitson HE, Allen LA, Suarez-Calvet M, Galasko D, Karikari TK, Okrahvi HR, Paczynski M, Schindler SE, Teunissen CE, Zetterberg H, Carrillo MC, Edelmayer RM, Mahinrad S, McAteer MB, Kahale LA, Pahlke S, Tampi MP.
Alzheimer's Association Clinical Practice Guideline on the use of blood-based biomarkers in the diagnostic workup of suspected Alzheimer's disease within specialized care settings
Alzheimer's & DementiaAbstractObjective and scope: A panel of clinicians, subject-matter experts, and guideline methodologists convened by the Alzheimer's Association conducted a systematic review and formulated evidence-based...
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Buongiorno M, Tur C, Giraldo DM, Cullell N, Krupinski J, Lanzillo R, Sánchez-Benavides G
Sleep and Risk of Multiple Sclerosis: Bridging the Gap Between Inflammation and Neurodegeneration via Glymphatic Failure
Brain SciencesAbstractEpidemiological studies identified insufficient and poor-quality sleep as independent risk factors for multiple sclerosis (MS). The glymphatic system, active during slow-wave sleep, clears brain waste...
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Suárez-Calvet M, Abdelnour C, Alcolea D, Mendióroz-Iriarte M, Balasa M, Morenas-Rodríguez E, Puig-Pijoan A, Sánchez-Juan P, Villarejo A, Sánchez-Valle R; por el Grupo de trabajo en biomarcadores en sangre del Grupo de Estudio de Conducta y Demencias de la Sociedad Española de Neurología.
Blood-based Biomarkers for Alzheimer's Disease: Positioning Document and Usage Recommendations from the Behavioral Neurology and Dementia Study Group of the Spanish Society of Neurology
NeurologíaAbstractIntroduction: The development of blood biomarkers for detecting Alzheimer's disease (AD) represents one of the most significant recent advances, and some are already available for clinical practice...
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Ossenkoppele R, Coomans EM, Apostolova LG, Baker SL, Barthel H, Beach TG, Benzinger TLS, Betthauser T, Bischof GN, Bottlaender M, Bourgeat P, den Braber A, Brendel M, Brickman AM, Cash DM, Carrillo MC, Coath W, Christian BT, Dickerson BC, Dore V, Drzezga A, Feizpour A, van der Flier WM, Franzmeier N, Frisoni GB, Garibotto V, van de Giessen E, Domingo-Gispert J, Gnoerich J, Gu Y, Guan Y, Hanseeuw BJ, Harrison TM, Jack CR, Jaeger E, Jagust WJ, Jansen WJ, La Joie R, Johnson KA, Johnson SC, Kennedy IA, Kim JP, van Laere K, Lagarde J, Lao P, Luchsinger JA, Kern S, Kreisl WC, Malotaux V, Malpetti M, Manly JJ, Mao X, Mattsson-Carlgren N; Mayo Clinic Study on Aging; Messerschmidt K, Minguillon C, Mormino EM, O'Brien JT, Palmqvist S, Peretti DE, Petersen RC, Pijnenburg YAL, Pontecorvo MJ, Poirier J; PREVENT-AD Research Group; Rabinovici GD, Rahmouni N, Risacher SL, Rosa-Neto P, Rosen H, Rowe CC, Rowe JB, Rullmann M, Salman Y, Sarazin M, Saykin AJ, Schneider JA, Schöll M, Schott JM, Seo SW, Serrano GE, Shcherbinin S, Shekari M, Skoog I, Smith R, Sperling RA, Spruyt L, Stomrud E, Strandberg O, Therriault J, Xie F, Vandenberghe R, Villemagne VL, Villeneuve S, Visser PJ, Vossler H, Young CB, Groot C, Hansson O
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex
Nature NeuroscienceAbstractTau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer's disease, which is associated with neurodegeneration and cognitive decline. Understanding how...
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Imam F, Saloner R, Vogel JW, Krish V, Abdel-Azim G, Ali M, An L, Anastasi F, Bennett D, Pichet Binette A, Boxer AL, Bringmann M, Burns JM, Cruchaga C, Dage JL, Farinas A, Ferrucci L, Finney CA, Frasier M, Hansson O, Hohman TJ, Johnson ECB, Kivimaki M, Korologou-Linden R, Ruiz Laza A, Levey AI, Liepelt-Scarfone I, Lu L, Mattsson-Carlgren N, Middleton LT, Nho K, Oh HS, Petersen RC, Reiman EM, Robinson O, Rothstein JD, Saykin AJ, Shvetcov A, Slawson C, Smets B, Suárez-Calvet M, Tijms BM, Timmers M, Vieira F, Vilor-Tejedor N, Visser PJ, Walker KA, Winchester LM, Wyss-Coray T, Yang C, Bose N, Lovestone S
he Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging
Nature MedicineAbstractMore than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment...
