Publicacions
Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.
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Salvadó G, Grothe MJ, Groot C, Moscoso A, Schöll M, Gispert JD, Ossenkoppele R
Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia
European Journal of Nuclear Medicine and Molecular ImagingAbstractPurpose: To examine associations between the APOE-ε2 and APOE-ε4 alleles and core Alzheimer's disease (AD) pathological hallmarks as measured by amyloid-β (Aβ) and tau PET in older individuals without...
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Martí-Juan G, Sanroma-Guell G, Cacciaglia R, Falcon C, Operto G, Molinuevo JL, González Ballester MÁ, Gispert JD, Piella G; Alzheimer's Disease Neuroimaging Initiative; ALFA Study
Nonlinear interaction between APOE ε4 allele load and age in the hippocampal surface of cognitively intact individuals
Human Brain MappingAbstractThe ε4 allele of the gene Apolipoprotein E is the major genetic risk factor for Alzheimer's Disease. APOE ε4 has been associated with changes in brain structure in cognitively impaired and unimpaired...
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Milà-Alomà M, Salvadó G, Shekari M, Grau-Rivera O, Sala-Vila A, Sánchez-Benavides G, Arenaza-Urquijo EM, González-de-Echávarri JM, Simon M, Kollmorgen G, Zetterberg H, Blennow K, Gispert JD, Suárez-Calvet M, Molinuevo JL
Comparative Analysis of Different Definitions of Amyloid-β Positivity to Detect Early Downstream Pathophysiological Alterations in Preclinical Alzheimer
J Prev Alzheimers DisAbstractAmyloid-β (Aβ) positivity is defined using different biomarkers and different criteria. Criteria used in symptomatic patients may conceal meaningful early Aβ pathology in preclinical Alzheimer...
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Sánchez-Benavides G, Salvadó G, Arenaza-Urquijo EM, Grau-Rivera O, Suárez-Calvet M, Milà-Alomà M, González-de-Echávarri JM, Minguillon C, Crous-Bou M, Niñerola-Baizán A, Perissinotti A, Gispert JD, Molinuevo JL; ALFA Study
Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
Alzheimers Dement (Amst)AbstractIntroduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron...
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Suárez-Calvet M, Karikari TK, Ashton NJ, Lantero Rodríguez J, Milà-Alomà M, Gispert JD, Salvadó G, Minguillon C, Fauria K, Shekari M, Grau-Rivera O, Arenaza-Urquijo EM, Sala-Vila A, Sánchez-Benavides G, González-de-Echávarri JM, Kollmorgen G, Stoops E, Vanmechelen E, Zetterberg H, Blennow K, Molinuevo JL; ALFA Study
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected
EMBO Molecular MedicineAbstractIn Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main...
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Milà-Alomà M, Salvadó G, Gispert JD, Vilor-Tejedor N, Grau-Rivera O, Sala-Vila A, Sánchez-Benavides G, Arenaza-Urquijo EM, Crous-Bou M, González-de-Echávarri JM, Minguillon C, Fauria K, Simon M, Kollmorgen G, Zetterberg H, Blennow K, Suárez-Calvet M, Molinuevo JL; ALFA study
Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
Alzheimer's DementiaAbstractIntroduction: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood.
Methods: We used NeuroToolKit and Elecsys® immunoassays to measure...
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Carles Falcon, Oriol Grau-Rivera, Marc Suárez-Calvet, Beatriz Bosch, Raquel Sánchez-Valle, Eider M Arenaza-Urquijo, José María González-de-Echavarri, Juan Domingo Gispert, Lorena Rami, José Luis Molinuevo
Sex differences of longitudinal brain changes in cognitively unimpaired adults
Journal of Alzheimer's DiseaseAbstractBackground: There is increasing evidence that AD progression differs by sex.
Objective: The aim of this work was to determine sex differences in the association of baseline levels of cerebrospinal...
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Natalia Vilor-Tejedor, Grégory Operto, Tavia E Evans, Carles Falcon, Marta Crous-Bou, Carolina Minguillón, Raffaele Cacciaglia, Marta Milà-Alomà, Oriol Grau-Rivera, Marc Suárez-Calvet, Diego Garrido-Martín, Sebastián Morán, Manel Esteller, Hieab H Adams, José Luis Molinuevo, Roderic Guigó, Juan Domingo Gispert, ALFA Study
Effect of BDNF Val66Met Polymorphism on Hippocampal Subfield Volumes and Compensatory Interaction with APOE-ε4
Brain Structure and FunctionAbstractBackground: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous...
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Casamitjana A, Vilaplana V, Puch S, Aduriz A, López C, Operto G, Cacciaglia R, Falcón C, Molinuevo JL, Gispert JD
NeAT: A Nonlinear Analysis Toolbox for Neuroimaging
NeuroinformaticsAbstractNeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely...
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Silvia Ingala, Linda Mazzai, Carole H Sudre, Gemma Salvadó, Anna Brugulat-Serrat, Viktor Wottschel, Carles Falcon, Grégory Operto, Betty Tijms, Juan Domingo Gispert, José Luis Molinuevo, Frederik Barkhof, ALFA Study
The relation between APOE genotype and cerebral microbleeds in a cognitively unimpaired middle- and late-aged individuals
Neurobiology of AgingAbstractPositive associations between cerebral microbleeds (CMBs) and APOE-ε4 (apolipoprotein E) genotype have been reported in Alzheimer's disease, but show conflicting results. We investigated the effect of...
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