Publicacions
Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.
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Casamitjana A, Vilaplana V, Puch S, Aduriz A, López C, Operto G, Cacciaglia R, Falcón C, Molinuevo JL, Gispert JD
NeAT: A Nonlinear Analysis Toolbox for Neuroimaging
NeuroinformaticsAbstractNeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely...
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Silvia Ingala, Linda Mazzai, Carole H Sudre, Gemma Salvadó, Anna Brugulat-Serrat, Viktor Wottschel, Carles Falcon, Grégory Operto, Betty Tijms, Juan Domingo Gispert, José Luis Molinuevo, Frederik Barkhof, ALFA Study
The relation between APOE genotype and cerebral microbleeds in a cognitively unimpaired middle- and late-aged individuals
Neurobiology of AgingAbstractPositive associations between cerebral microbleeds (CMBs) and APOE-ε4 (apolipoprotein E) genotype have been reported in Alzheimer's disease, but show conflicting results. We investigated the effect of...
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Raffaele Cacciaglia, José Luis Molinuevo, Carles Falcón, Eider M Arenaza-Urquijo, Gonzalo Sánchez-Benavides, Anna Brugulat-Serrat, Kaj Blennow, Henrik Zetterberg, Juan Domingo Gispert, ALFA study
APOE-e4 shapes the cerebral organization in cognitively intact individuals as reflected by structural gray matter networks
Cerebral CortexAbstractGray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the...
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Heeman F, Yaqub M, Lopes Alves I, Heurling K, Bullich S, Gispert JD , Boellaard R, Lammertsma AA; AMYPAD Consortium.
Simulating the Effect of Cerebral Blood Flow Changes on Regional Quantification of [ 18 F]flutemetamol and [ 18 F]florbetaben Studies
J Cereb Blood Flow MetabAbstractGlobal and regional changes in cerebral blood flow (CBF) can result in biased quantitative estimates of amyloid load by PET imaging. Therefore, the current simulation study assessed effects of these...
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Cacciaglia R , Molinuevo JL , Falcón C , Arenaza-Urquijo EM , Sánchez-Benavides G , Brugulat-Serrat A, Blennow K, Gispert JD
APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks
Cereb CortexAbstractGray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the...
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Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, José L Molinuevo, ALFA Study
Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal down-regulation
BrainAbstractResearch into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological continuum of Alzheimer's disease. In...
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Grau-Rivera O, Operto G, Falcón C, Sánchez-Benavides G, Cacciaglia R, Brugulat-Serrat A, Gramunt N, Salvadó G, Suárez-Calvet M, Minguillon C, Iranzo Á, Gispert JD, Molinuevo JL, ALFA Study
Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
Alzheimer's Research & TherapyAbstractBackground: Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study...
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Brugulat-Serrat A, Salvadó G, Operto G, Cacciaglia R, Sudre CH, Grau-Rivera O, Suárez-Calvet M, Falcon C, Sánchez-Benavides G, Gramunt N, Minguillon C, Fauria K, Barkhof F, Molinuevo JL, Gispert JD, ALFA Study
White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
Human Brain MappingAbstractWhite matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume...
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Petrone PM, Casamitjana A, Falcon C, Artigues M, Operto G, Cacciaglia R, Molinuevo JL, Vilaplana V, Molinuevo JL, Alzheimer’s Disease Neuroimaging Initiative
Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI
Alzheimer's Research & TherapyAbstractBackground: Magnetic resonance imaging (MRI) has unveiled specific alterations at different stages of Alzheimer's disease (AD) pathophysiologic continuum constituting what has been established as "AD...
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Brugulat-Serrat A, Salvadó G, Sudre CH, Grau-Rivera O,
Suárez-Calvet M , Falcon C, Sánchez-Benavides G, Gramunt N, Fauria K, Cardoso MJ, Barkhof F, Molinuevo JL, Gispert JD, ALFA StudyPatterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals
Brain Imaging and BehaviorAbstractWhite matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the...
