Publicacions
Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.
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Cacciaglia R, Molinuevo JL, Falcón C, Sánchez-Benavides G, Gramunt N, Brugulat-Serrat A, Esteller M, Morán S, Fauria K, Gispert JD, ALFA study
APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals
Neuroimage: ClinicalAbstractThe APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier...
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Salvadó G, Molinuevo JL, Brugulat-Serrat A, Falcon C, Grau-Rivera O, Suárez-Calvet M, Pavia J, Niñerola-Baizán A, Perissinotti A, Lomeña F, Minguillon C, Fauria K, Zetterberg H, Blennow K, Gispert JD, Alzheimer’s Disease Neuroimaging Initiative, for the ALFA Study
Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers
Alzheimer's Research & TherapyAbstractBackground: The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization...
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Salvadó G, Brugulat-Serrat A, Sudre CH, Grau-Rivera O, Suárez-Calvet M, Falcon C, Fauria K, Cardoso MJ, Barkhof F, Molinuevo JL, Gispert JD, ALFA Study
Spatial patterns of white matter hyperintensities associated with Alzheimer's disease risk factors in a cognitively healthy middle-aged cohort
Alzheimer's Research & TherapyAbstractBackground: White matter hyperintensities (WMH) of presumed vascular origin have been associated with an increased risk of Alzheimer's disease (AD). This study aims to describe the patterns of WMH...
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Sánchez-Benavides G, Grau-Rivera O, Suárez-Calvet M, Minguillon C, Cacciaglia R, Gramunt N, Falcon C, Gispert JD, Molinuevo JL
Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort
Alzheimer's Research & TherapyAbstractBackground: Subjective cognitive decline (SCD) consists of self-perceived decline in cognition over time. The occurrence of specific additional features in SCD (so-called SCDplus) confers a higher...
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Sánchez-Benavides G, Grau-Rivera O, Cacciaglia R, Suárez-Calvet M, Falcon C, Minguillón C, Gramunt N, Gispert JD, Molinuevo JL
Distinct Cognitive and Brain Morphological Features in Healthy Subjects Unaware of Informant-Reported Cognitive Decline
Journal of Alzheimer's DiseaseAbstractBackground: Subtle cognitive decline preceding cognitive impairment can be self-perceived, referred to as subjective cognitive decline (SCD), or go unrecognized. Objective: To study the clinical...
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Cacciaglia R, Molinuevo JL, Falcón C, Brugulat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillon C, Fauria K, Gispert JD
Impact of APOE genetic variant on brain morphology in a cohort of cognitively healthy middle-aged individuals with enriched genetic risk for Alzheimer’s disease
Alzheimer's DementiaAbstractIntroduction: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains...
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Cacciaglia R, Molinuevo JL, Sánchez-Benavides G, Falcon C, Gramunt N, Brugulat-Serrat A, Grau-Rivera O, Gispert JD
Episodic Memory and Executive Function in cognitively Healthy Individuals Display Distinct Neuroanatomical Correlates which are Differentially Modulated by Aging
Human Brain MappingAbstractThe neuroanatomical bases of episodic memory (EM) and executive functions (EFs) have been widely addressed in patients with brain damage and in individuals with neurologic disorders. These studies...
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Cacciaglia R, Molinuevo JL, Falcón C, Brugulat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillon C, Fauria K, Gispert JD
Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease
Alzheimer's & DementiaAbstractIntroduction: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains...
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Casamitjana A, Petrone P, Tucholka A, Falcon C, Skouras S, Molinuevo JL, Vilaplana V, Gispert JD, for the Alzheimer's Disease Neuroimaging Initiative
MRI-Based Screening of Preclinical Alzheimer’s Disease for Prevention Clinical Trials
Journal of Alzheimer's DiseaseAbstractThe identification of healthy individuals harboring amyloid pathology represents one important challenge for secondary prevention clinical trials in Alzheimer's disease (AD). Consequently, noninvasive...
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Operto G, Cacciaglia R, Grau O, Falcón C, Brugulat-Serrat A, Ródenas P, Ramos R, Morán S, Esteller M, Bargalló N, Molinuevo JL, Gispert JD
White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes
Alzheimer's Research & TherapyAbstractBackground: The ε4 allele of the apolipoprotein E gene (APOE-ε4) is the strongest genetic factor for late-onset Alzheimer's disease. During middle age, cognitively healthy APOE-ε4 carriers already...
