Artículos sobre Alzheimer
Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.
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Karikari TK, Benedet AL, Ashton NJ, Lantero Rodriguez J, Snellman A, Suárez-Calvet M, Saha-Chaudhuri P, Lussier F, Kvartsberg H, Rial AM, Pascoal TA, Andreasson U, Schöll M, Weiner MW, Rosa-Neto P, Trojanowski JQ, Shaw LM, Blennow K, Zetterberg H; Alzheimer’s Disease Neuroimaging Initiative
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative
Molecular PsychiatryAbstractWhilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for amyloid-β (Aβ) and tau pathologies are accurate for the diagnosis of Alzheimer's disease (AD), their broad...
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Milà-Alomà M, Salvadó G, Gispert JD, Vilor-Tejedor N, Grau-Rivera O, Sala-Vila A, Sánchez-Benavides G, Arenaza-Urquijo EM, Crous-Bou M, González-de-Echávarri JM, Minguillon C, Fauria K, Simon M, Kollmorgen G, Zetterberg H, Blennow K, Suárez-Calvet M, Molinuevo JL; ALFA study
Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
Alzheimer's DementiaAbstractIntroduction: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood.
Methods: We used NeuroToolKit and Elecsys® immunoassays to measure...
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Franzmeier N, Suárez-Calvet M, Frontzkowski L, Moore A, Hohman TJ, Morenas-Rodriguez E, Nuscher B, Shaw L, Trojanowski JQ, Dichgans M, Kleinberger G, Haass C, Ewers M; Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration
Molecular NeurodegenerationAbstractBackground: The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a...
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Carles Falcon, Oriol Grau-Rivera, Marc Suárez-Calvet, Beatriz Bosch, Raquel Sánchez-Valle, Eider M Arenaza-Urquijo, José María González-de-Echavarri, Juan Domingo Gispert, Lorena Rami, José Luis Molinuevo
Sex differences of longitudinal brain changes in cognitively unimpaired adults
Journal of Alzheimer's DiseaseAbstractBackground: There is increasing evidence that AD progression differs by sex.
Objective: The aim of this work was to determine sex differences in the association of baseline levels of cerebrospinal...
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Natalia Vilor-Tejedor, Grégory Operto, Tavia E Evans, Carles Falcon, Marta Crous-Bou, Carolina Minguillón, Raffaele Cacciaglia, Marta Milà-Alomà, Oriol Grau-Rivera, Marc Suárez-Calvet, Diego Garrido-Martín, Sebastián Morán, Manel Esteller, Hieab H Adams, José Luis Molinuevo, Roderic Guigó, Juan Domingo Gispert, ALFA Study
Effect of BDNF Val66Met Polymorphism on Hippocampal Subfield Volumes and Compensatory Interaction with APOE-ε4
Brain Structure and FunctionAbstractBackground: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous...
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Ashton NJ, Hye A, Rajkumar AP, Leuzy A, Snowden S, Suárez-Calvet M, Karikari TK, Schöll M, La Joie R, Rabinovici GD, Höglund K, Ballard C, Hortobágyi T, Svenningsson P, Blennow K, Zetterberg H, Aarsland D
An Update on Blood-Based Biomarkers for non-Alzheimer Neurodegenerative Disorders
Nat Rev NeurolAbstractCerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for...
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Grau-Rivera O, Operto G, Falcón C, Sánchez-Benavides G, Cacciaglia R, Brugulat-Serrat A, Gramunt N, Salvadó G, Suárez-Calvet M, Minguillon C, Iranzo Á, Gispert JD, Molinuevo JL, ALFA Study
Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
Alzheimer's Research & TherapyAbstractBackground: Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study...
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Latest advances in cerebrospinal fluid and blood biomarkers of Alzheimer's disease
Therapeutic Advances in Neurological DisordersAbstractAlzheimer's disease (AD) is the most common neurodegenerative disease and its diagnosis has classically been based on clinical symptoms. Recently, a biological rather than a syndromic definition of...
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Brugulat-Serrat A, Salvadó G, Operto G, Cacciaglia R, Sudre CH, Grau-Rivera O, Suárez-Calvet M, Falcon C, Sánchez-Benavides G, Gramunt N, Minguillon C, Fauria K, Barkhof F, Molinuevo JL, Gispert JD, ALFA Study
White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
Human Brain MappingAbstractWhite matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume...
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Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C, Brett TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Science Translational MedicineAbstractSoluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer's disease (AD). TREM2 plays a critical role in microglial activation...
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