Clinical Project Manager (Science Driven)

Context

The Pasqual Maragall Foundation was established in 2008 with the mission to promote and conduct excellent biomedical research. The Foundation is deeply committed to making a decisive contribution to global solutions for Alzheimer’s disease and related dementias, as well as to raising public awareness to ensure that scientific efforts addressing these challenges receive the priority they deserve.

Research at the Foundation is carried out at the Barcelonaßeta Brain Research Center (BBRC), a research center established in collaboration with Pompeu Fabra University and "la Caixa" Foundation.

The vision of the Pasqual Maragall Foundation is to achieve “A future without Alzheimer’s”, within a framework of active and healthy aging associated with positive experiences and free from cognitive decline. To this end, the BBRC focuses its research on the primary and secondary prevention of Alzheimer’s disease, made possible through the participation of thousands of volunteers who contribute to scientific studies aimed at significantly reducing the number of people affected in the future.

The Pasqual Maragall Foundation is a private, non-profit organization. Its funding comes from philanthropic donations from organizations and companies, as well as from a network of over 100,000 members who support the Foundation’s research. The scientific staff at the BBRC also secures competitive grants and funding, mainly from European funds and international foundations.

For more information, please visit our websites: www.fpmaragall.org , www.barcelonabeta.org

The Pasqual Maragall Foundation is a young, consolidated, and growing institution that, together with the BBRC, currently brings together over 250 professionals. The Foundation’s team includes transversal areas such as infrastructure, IT, finance, procurement, human resources, communications, public engagement, and philanthropic fundraising. The BBRC scientific team comprises researchers and professionals from diverse disciplines such as medicine, biology, psychology, and nursing, among others — all within a dynamic environment where continuous challenges are part of everyday work.

About the position

The Clinical Project Manager (CPM) is responsible for the planning, coordination, execution, and monitoring of clinical research projects at the Barcelonaβeta Brain Research Center (BBRC), with a focus on interventional clinical trials and BBRC’s flagship observational cohort studies (ALFA and ALFA10) in Alzheimer’s disease and related neurodegenerative disorders.
Embedded within Scientific Coordination and Research Support, the CPM is a scientifically conversant project leader who can understand the underlying research questions, endpoints, and methodological rationale of each study and translate them into robust, feasible, and high-quality execution plans. This role contributes to research governance and the implementation and promotion of institutional scientific standards, ensuring consistency, traceability, and alignment with the BBRC mission across group-led and institutional projects. The CPM works closely with Principal Investigators and multidisciplinary teams to ensure that study delivery
remains faithful to scientific objectives while meeting regulatory, ethical, quality, and timeline requirements.The selected candidate will report to the Director of Scientific Coordination and Research Support.

Main responsabilities

Scientific Project Leadership

• Partner with Principal Investigators to clarify and operationalize the scientific question(s) each study is designed to address (hypotheses, objectives, endpoints, target population, and key analyses).
• Ensure scientific objectives are consistently reflected in protocol design choices, visit schedules, assessments, sample collection plans, and data capture strategies.
• Facilitate cross-functional alignment (clinical operations, biomarkers/biobank, imaging, data management, statistics/biometrics) to ensure data integrity and fitness-for-purpose for downstream analyses and publications.
• Anticipate scientific/operational trade-offs (feasibility vs. depth of phenotyping, participant burden, missingness risk) and proactively propose solutions with the PI team.

Project Planning & Study Setup

• Participate in the design, planning, and start-up of clinical research projects (interventional and observational), including ALFA and ALFA10 cohort activities as applicable.
• Support the preparation and review of study documents with a scientific quality lens (protocol rationale, endpoints, assessment schedules, data collection requirements, and analysis-readiness).
• Coordinate the definition of study deliverables that support scientific outputs (e.g., analysis datasets, interim milestones, publication-supporting documentation).
• Coordinate protocol development, feasibility assessments, regulatory submissions, and ethics approvals.
• Support the preparation and maintenance of study documentation: protocols, informed consent forms, monitoring plans, SOPs, manuals/working instructions, study trackers, and project timelines.
• Support study governance readiness: RACI/roles, decision logs, risk registers, vendor plans, and cross-functional kick-offs.
   

Project Coordination & Implementation

•  Lead day-to-day project operations to ensure successful execution of clinical studies in an efficient, transparent manner.
• Coordinate with clinical and operational teams (neurology, neuropsychology, imaging, laboratory/biobank, recruitment/participant engagement, data management, statistics, quality).
• Ensure project milestones, budgets, and deliverables are met, anticipating constraints and proactively escalating risks when needed.
• Oversee participant recruitment support, visit scheduling logistics, follow-up adherence, and operational feasibility for complex cohort protocols.
• Manage communication with sponsors, CROs, collaborating centers, vendors, and subcontractors; ensure meeting cadence, minutes, action follow-up, and alignment across stakeholders.

Key Programs:  ALFA and ALFA10. Within BBRC’s flagship observational cohort portfolio, the CPM will contribute to the scientific and operational delivery of ALFA and ALFA10, supporting research designed to characterize the earliest biological and clinical changes along the Alzheimer’s disease continuum. This includes enabling high-quality longitudinal follow-up and multimodal data generation (e.g., clinical and cognitive phenotyping, biofluid and imaging-based biomarkers, and other platform-specific assessments as applicable), ensuring protocol fidelity, rigorous documentation and traceability, and cross- functional alignment across research, clinical operations, data/biometrics, and external collaborators. The CPM will help translate scientific objectives into executable study plans, safeguard data and sample integrity through robust workflows, and support study governance to ensure timely, consistent, and publication-ready outputs.

Regulatory & Quality Compliance
 

• Ensure studies adhere to ICH-GCP (for interventional trials), applicable EU/Spanish regulations, ethics requirements, and BBRC quality systems.
• Promote and safeguard institutional scientific standards through consistent documentation practices, version control, and traceability.
• Ensure maintenance, completeness, and audit readiness of the Trial Master File (TMF) and/or study master files (as applicable to observational cohorts).
• Support audits, inspections, CAPAs, and internal quality processes, in coordination
  with relevant BBRC units.

Monitoring & Reporting

• Track study progress, KPIs, risks, deviations, and key decisions; maintain dashboards/trackers.
• Track not only operational KPIs but also science-critical indicators (data completeness, protocol adherence, visit window compliance, sample processing timelines/quality flags, missing data drivers).
• Prepare internal and external progress reports, metrics, and documentation for sponsors, collaborators, and governance bodies.
• Participate in data review meetings, safety assessments (when applicable), and monitoring oversight, ensuring timely follow-up of action items.

Financial & Contract Management

• Support budget preparation, cost tracking, purchase/billing coordination, and forecasting.
• Assist in contract negotiation, follow-up, and deliverable control with vendors, service
  providers, CROs, and collaborators.

Cross-functional Collaboration & Continuous Improvement

•  Work in close coordination with BBRC scientific leadership, project investigators, and administrative/operational units to ensure alignment and efficiency.
• Provide administrative and logistical support that enables researchers’ activities (planning, coordination, documentation, and operational workflows).
• Contribute to continuous improvement and harmonization of clinical research processes, including templates, SOPs, and project governance routines across BBRC’s portfolio.

Qualifications and Experience

• Bachelor’s or Master’s degree in Life Sciences, Health Sciences, Neuroscience, Biomedical Engineering, Pharmacy, Biostatistics, Psychology, or related fields.
• Strong research training is required; advanced degree (MSc/PhD) or equivalent research experience is highly valued.
• Minimum 3–5 years of experience in clinical trial/project management.
• Demonstrated ability to work close to scientific leadership (PIs) and to understand and operationalize research objectives, endpoints, and methodological constraints.
• Experience in observational research and/or complex clinical research pipelines (biomarkers, imaging, longitudinal follow-up) is strongly preferred.
• Proven experience coordinating multicenter studies; experience in observational cohort studies is a strong asset, ideally in neurology or cognitive disorders.
• Strong knowledge of Spanish/EU regulations, international guidelines (ICH-GCP), and ethics procedures.
• Experience working with CROs, vendors, and external collaborators.

Technical Competencies
 

• Ability to interpret protocols and study plans with a scientific mindset (hypotheses, endpoints, confounders, sources of bias, data quality risks).
• Comfortable collaborating with statistics/biometrics and data management to ensure analysis-ready data and reproducible documentation.
• Solid understanding of study operations, monitoring processes, regulatory pathways, and data management.
• Experience with eCRFs, CTMS, EDC platforms, and quality documentation systems.
• Strong project management, risk management, and stakeholder management skills.
• Languages: Spanish and English (professional proficiency required); Catalan (valued).

Personal skills

• Scientific curiosity and critical thinking: ability to ask the right questions and connect operational choices to scientific validity.
• Ability to communicate complex scientific and operational concepts clearly to multidisciplinary stakeholders.
• Excellent organizational and time-management skills; strong attention to detail.
• Strong communication abilities (written and spoken) and ability to facilitate multidisciplinary coordination.
• Ability to manage multiple projects in parallel and work under timelines.
• Team-oriented mindset with capacity to work across disciplines and functions.
• Proactive, problem-solving approach, high integrity, and strong commitment to quality and compliance.

Position Details

• Start date: Immediate.
• Contract: Permanent.
• Working hours: Full-time (38 hours/week).
• Salary: Based on experience and aligned with BBRC’s compensation policy and Development Plan.
• Benefits: Flexible compensation plan (meal card, health insurance, childcare).
• Holidays: 23 working days per year (pro rata), plus additional days coinciding with long weekends and during March–April and December periods.
• We offer: A highly stimulating work environment with unique infrastructures and professional development opportunities.

Application Process

• Applicants must submit a single PDF file including:
• Motivation letter highlighting interests, experience, and motivation to join the Foundation’s mission.
• Updated CV.
• References: Up to three references may be requested at a later stage of the selection process. All documentation must be sent confidentially by email to talent@barcelonabeta.org , indicating in the subject line: Clinical Project Manager (Science Driven)

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