Artículos sobre Alzheimer
Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.
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González-Escalante A, Milà-Alomà M, Brum WS, Ashton NJ, Ortiz-Romero P, Shekari M, Campo MD, Anastasi F, Quijano-Rubio C, Kollmorgen G, Minguillón C, Sánchez-Benavides G, Grau-Rivera O, Gispert JD, Zetterberg H, Vilor-Tejedor N, Blennow K, Suárez-Calvet M.
A plasma biomarker panel for detecting early amyloid-β accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer's disease
EBioMedicineAbstractBackground: Plasma biomarkers of Alzheimer's disease (AD) change during preclinical stages, indicating potential for detecting amyloid-β (Aβ) pathology in cognitively unimpaired (CU) individuals...
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López-Martos D, Brugulat-Serrat A, Suárez-Calvet M, Milà-Alomà M, Minguillon C, Domingo Gispert J, Zetterberg H, Blennow K, Grau-Rivera O, Sánchez-Benavides G
Robust longitudinal neuropsychological norms in Spanish individuals with nonpathological Alzheimer's disease biomarkers
NeuropsychologyAbstractObjective: Neuropsychological norms serve to identify cognitive impairment and monitor neurodegenerative disease progression. However, longitudinal data are limited, and conventional approaches do not...
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Ashton NJ, Benedet AL, Molfetta GD, Pola I, Anastasi F, Fernández-Lebrero A, Puig-Pijoan A, Keshavan A, Schott J, Tan K, Simrén J, Gomes BF, Montoliu-Gaya L, Isaacson R, Bongianni M, Tolassi C, Cantoni V, Alberici A, Padovani A, Zanusso G, Pilotto A, Borroni B, Suárez-Calvet M, Blennow K, Zetterberg H.
Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay
Alzheimer's & DementiaAbstractIntroduction: Recent advancements in immunological methods accurately quantify biofluid biomarkers for Alzheimer's disease (AD) pathology. Despite progress, more biomarkers, ideally in blood, are...
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Laurell AAS, Mak E, Dounavi ME, Underwood BR, Dauvilliers Y, Dudas RB, Marguet O, Ritchie CW, Koychev I, Lawlor BA, Naci L, Malhotra P, Grau-Rivera O, Gispert JD, O'Brien JT
Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults. Alzheimers Dement
Alzheimer's & DementiaAbstractIntroduction: Sleep dysfunction in those at higher risk of dementia may be associated with early structural changes to the hypothalamus.
Methods: We used multivariate regression to analyze self...
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Heo G, Xu Y, Wang E, Ali M, Oh HS, Moran-Losada P, Anastasi F, González Escalante A, Puerta R, Song S, Timsina J, Liu M, Western D, Gong K, Chen Y, Kohlfeld P, Flynn A, Thomas AG, Lowery J, Morris JC, Holtzman DM, Perlmutter JS, Schindler SE, Vilor-Tejedor N, Suárez-Calvet M, García-González P, Marquié M, Fernández MV, Boada M, Cano A, Ruiz A, Zhang B, Bennett DA, Benzinger T, Wyss-Coray T, Ibanez L, Sung YJ, Cruchaga C.
Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer's disease
Nature AgingAbstractProteomic studies have been instrumental in identifying brain, cerebrospinal fluid and plasma proteins associated with Alzheimer's disease (AD). Here, we comprehensively examined 6,905 aptamers...
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Sclafani A, Migueles JH, Olvera-Rojas M, Solis-Urra P, Fernandez-Gamez B, Coca-Pulido A, Bellón D, Fernández-Ortega J, Sanchez-Martinez J, Sánchez-Aranda L, Toval Á, Martín-Fuentes I, Bakker EA, Gispert JD, Triviño-Ibañez EM, Liu-Ambrose T, Erickson KI, Gomez-Rio M, Ortega FB, Esteban-Cornejo I.
Association of 24 h-movement behaviors with cerebral and hippocampal amyloid beta levels and executive function in cognitively normal older adults: a compositional data analysis from the AGUEDA trial
Journal of science and medicine of sportAbstractObjectives: This study investigated the associations between movement behaviors (physical activity, sedentary behavior, and sleep duration), global and hippocampal amyloid beta levels, and executive...
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Carmona R, Roldán G, Fernández-Rueda JL, Navarro A, Peña-Chilet M; CSVS Crowdsourcing Group; Dopazo J, López-López D.
The Spanish Polygenic Score reference distribution: a resource for personalized medicine
European Journal of Human GeneticsAbstractHere we present the Polygenic Score (PGS) distributions for 3124 common diseases and quantitative traits observed in the Spanish population. To achieve so, the genomes and exomes of 2190 unrelated...
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Alessiani M, Bonura A, Iaccarino G, Rossi SS, Mangiardi M, Bravi MC, Pezzella FR, de Rubeis G, Pampana E, Anticoli S.
Safety and efficacy of mechanical thrombectomy in distal medium vessel occlusions: Experience and real-world data from an Italian stroke hub centre
Journal of stroke and cerebrovascular diseasesAbstractBackground and purpose: Distal-medium vessel occlusions (DMVOs) contribute to approximately 25-40 % of cases of ischemic stroke. Intravenous thrombolysis (IVT) achieved a complete recanalization in...
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Cumplido-Mayoral I, Sánchez-Benavides G, Vilor-Tejedor N, López-Martos D, Brugulat-Serrat A, Milà-Alomà M, Falcon C, Cacciaglia R, Minguillón C, Fauria K, Kollmorgen G, Quijano-Rubio C, Molinuevo JL, Grau-Rivera O, Suárez-Calvet M, Vilaplana V, Gispert JD
Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers.
Molecular PsychiatryAbstractMagnetic resonance Imaging (MRI)-derived brain-age prediction is a promising biomarker of biological brain aging. Accelerated brain aging has been found in Alzheimer's disease (AD) and other...
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Palmqvist S, Warmenhoven N, Anastasi F, Pilotto A, Janelidze S, Tideman P, Stomrud E, Mattsson-Carlgren N, Smith R, Ossenkoppele R, Tan K, Dittrich A, Skoog I, Zetterberg H, Quaresima V, Tolassi C, Höglund K, Brugnoni D, Puig-Pijoan A, Fernández-Lebrero A, Contador J, Padovani A, Monane M, Verghese PB, Braunstein JB, Kern S, Blennow K, Ashton NJ, Suárez-Calvet M, Hansson O.
Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform
Nature MedicineAbstractGlobal implementation of blood tests for Alzheimer's disease (AD) would be facilitated by easily scalable, cost-effective and accurate tests. In the present study, we evaluated plasma phospho-tau217...
