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Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.

  • Tort-Colet N, Stankeviciute L, Fernández-Arcos A, Soldevila-Domenech N, Sánchez-Benavides G, Shekari M, Vállez García D, Altomare D, Barkhof F, Boada M, Buckley C, Collij LE, den Braber A, Farrar G, Ford L, Frisoni GB, Gismondi R, Gispert JD, Grootoonk S, Hanseeuw BJ, Jessen F, Luckett ES, Manber R, Marquié M, Mett A, Quenon L, Ritchie C, Schmidt ME, Schöll M, Stephens AW, Vandenberghe R, Visser PJ, Wolz R, Grau-Rivera O; AMYPAD Consortium

    Self-reported sleep quality and longitudinal amyloid burden in clinically unimpaired adults from the AMYPAD PNHS study

    Alzheimer's Research & Therapy
  • Molina-Berenguer M, Herrero-Martínez D, Vallbona-Garcia A, Vila-Julià F, Cámara Y, Vales Á, González-Aseguinolaza G, Torres-Torronteras J, Martí R

    Systemic delivery of AAV-GFM1 corrects COXPD1 molecular alterations in Gfm1R671C/- mice

    EMBO Molecular Medicine
    Abstract

    Hepatoencephalopathy due to mutations in the nuclear gene GFM1, known as combined oxidative phosphorylation (OXPHOS) deficiency type I (COXPD1), is an autosomal recessive mitochondrial disease caused...

  • Shekari M, Escalante AG, Milà-Alomà M, Falcon C, López-Martos D, Sánchez-Benavides G, Brugulat-Serrat A, Niñerola-Baizán A, Ashton NJ, Karikari TK, Lantero-Rodriguez J, Montoliu-Gaya L, Snellman A, Day TA, Dage JL, Ortiz-Romero P, Tonietto M, Borroni E, Klein G, Kollmorgen G, Carboni M, Quijano-Rubio C, Vanmechelen E, Minguillón C, Fauria K, Perissinotti A, Molinuevo JL, Zetterberg H, Blennow K, Grau-Rivera O, Suárez-Calvet M, Gispert JD; ALFA Study.

    Associations of 18F-RO-948 tau PET with fluid AD biomarkers, Centiloid, and cognition in early AD continuum

    Alzheimer's & Dementia
    Abstract

    Introduction: We examined neurofibrillary tangle (NFT) pathology using 18F-RO-948 tau positron emission tomography (PET) in cognitively unimpaired individuals and its associations with amyloid plaques...

  • Vilor-Tejedor N, van Vorstenbosch R, Evans TE

    Artificial intelligence in dementia care: challenges, controversies, and policy implications

    Frontiers in Dementia
    Abstract

    Artificial intelligence (AI) is rapidly expanding into dementia-related health and social care, with proposed applications ranging from early risk detection and monitoring to care coordination and...

  • Legaz A, Moguilner S, Barttfeld P, Cuadros Castro J, Galván Rial DS, Migeot J, Farina FR, Gonzalez-Gomez R, Salazar-Londoño S, de Souza Azzi T, Alcauter S, Amoruso L, Anghinah R, Bakr M, Behrens MI, Bruno MA, Cardona JF, Chen C, Colliot O, Custodio N, d'Acremont Q, Debette S, Dzianok P, Güntekin B, Huguet J, Jarne C, Joliot M, Karageorgiou E, Khedr EM, Koopowitz SM, Kublik E, Lee J, Aksman L, Lopez S, Margaretic P, Matallana D, Matis S, Miltiadous A, Novotni G, Orio P, Parra MA, Reppermund S, de Paula França Resende E, Salum GA, Slachevsky A, Ortiz ALS, Takada LT, Toh AQ, Tzallas A, Wen W, Whelan R, Yener G, Zegarra Valdivia JA, Alexoudi A, Arshad F, Atta H, Avila-Funes JA, Santos JB, Bruña R, Castelblanco-Toro SM, Chino Vilca BN, Coronel-Oliveros C, Crivello F, Cruzat J, Dellavale D, Dhooge C, Di Caterina G, Escudero J, Esquivias Farias JM, Eze LU, Evans TE, Farombi T, Fernández A, Fittipaldi S, Portillo F, Martinic GF, García AM, Garcia-Cordero I, Gaurav R, Godoy ME, Gonzalez Campo C, González Hernández A, Hanoğlu L, Hazelton JL, Herzog R, Ikiz B, Njamnshi AK, Landin-Romero R, López ME, Maito MA, Medel V, Sepúlveda JPM, Ochoa Gómez JF, Ogbuagu C, de Oliveira MO, Ozansoy M, Palma-Espinosa J, Hilal S, Zhou JH, Escudero SDP, Pitman JK, Prado P, Ramírez González D, Reyes P, Santamaría García H, Schröder J, Sitt JD, Soliman RK, Soto-Añari M, Thanissery N, Ito LT, Tsuchida A, Tzourio C, Yırıkoğulları H, Yokoyama JS, Aguillon D, Miller B, Alladi S, Jiang Y, Navarro A, Babiloni C, Huepe Artigas D, Piguet O, Sosa PAV, Mostert CM, Tahmasian M, Li P, Hu K, Genon S, Stein DJ, Maestú F, Pievani M, Salama M, Brodaty H, Sachdev PS, Lawlor B, Eyre HA, Miranda JJ, Baez S, Tagliazucchi E, Duran-Aniotz C, Hernandez H, Ibanez A.

    The exposome of brain aging across 34 countries

    Nature Medicine
    Abstract

    The physical and social exposome affects human aging, and brain clocks may track its effects. However, most studies neglect multidomain exposures (physical, social and political) across diverse...

  • Rehman D, Chen HY, Lee CC, Vilor-Tejedor N, Upadhyay S, Kuo PC.

    Diffusion-synthesized Chest X-rays improve fairness and diagnostic performance

    PLOS Digital Health
    Abstract

    Deep learning models have been widely applied to chest X-ray (CXR) disease classification and diagnosis; however, challenges such as data scarcity and shortcut learning often lead to biased model...

  • Mattsson-Carlgren N, Palmqvist S, Horie K, Barthélemy N, Salvadó G, Binette AP, Tideman P, Morris JC, Benzinger TL, Perrin RJ, Janelidze S, Collij LE, Ossenkoppele R, Schindler SE, Stomrud E, Bateman RJ, Hansson O.

    Integration of plasma eMTBR-tau243 and p-tau217 in the diagnosis and stratification of Alzheimer's disease: a prospective cohort study

    The Lancet Neurology
    Abstract

    Background: Alzheimer's disease pathology can be accurately identified with blood biomarkers (core 1 biomarkers), including plasma p-tau217 tests. Biomarkers that change longitudinally after diagnosis...

  • Hortsch S, Domenico AD, Borlinghaus N, Caley D, Kaminioti-Dumont L, Jeppesen SB, González-Escalante A, Ritchie C, Frederiksen KS, Suárez-Calvet M.

    Performance of a fully automated plasma tau phosphorylated at threonine 217 immunoassay to reflect amyloid-beta burden in an unselected cohort representative of clinical practice

    The journal of prevention of Alzheimer's Disease
    Abstract

    Background: With the emergence of disease-modifying anti-amyloid-beta (Aβ) therapies for Alzheimer's disease (AD), early and accurate quantitative measures of Aβ burden are critical. Blood-based...

  • Salemme S, Mukadam N, Bodryzlova Y, Blossom SCM, Brayne C, Richard E, Seshadri S, Ma'u E, Akinyemi RO, Urso D, Wolters FJ, Grasset L, Dufouil C, Ferri CP, Langa KM, Kalaria R, McKenzie BL, Röhr S, Ibáñez A, Lautenschlage NT, Cullum S, Bobrow K, Anstey KJ, Wallace L, Walsh S; PLADRR Research Group.

    Operationalising dementia prevention as a measurable NCD priority

    The Lancet. Public Health
    Abstract

    Not available

  • Reiman EM, Alexander RC, Langbaum JB, Aisen PS, Ashton N, Atri A, Barbarino P, Byrd GS, Feldman HH, Fowler NR, Ghisays V, Grill JD, Hassenstab J, Heaton GR, Herring WL, Jack CR Jr, Johnson SC, Karlawish J, Keach NL, Kivipelto M, Krumholz HM, Largent EA, MaGee-Rodgers T, McDade E, Mielke MM, Molina-Henry D, Petersen RC, Rabinovici GD, Ritchie C, Schindler SE, Sperling RA, Suárez-Calvet M, Vradenburg G, Weiner MW, Welsh-Bohmer KA, Zetterberg H, Zuendel MT, Mattke S, Cummings JL

    A path to preventing cognitive impairment due to Alzheimer's disease: initiatives beginning in the USA

    The Lancet Neurology
    Abstract

    Antibody therapies can remove amyloid plaques from the brain and slow cognitive decline in people with Alzheimer's disease who are mildly impaired. These drugs are now being evaluated in participants...