Artículos sobre Alzheimer
Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.
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Cortes Cabrera A,
Petrone PM Optimal HTS Fingerprint Definitions by Using a Desirability Function and a Genetic Algorithm
Journal of Chemical Information and ModelingAbstractThe use of compound biological fingerprints built on data from high-throughput screening (HTS) campaigns, or HTS fingerprints, is a novel cheminformatics method of representing compounds by... -
Chang SC, Crous-Bou M, Prescott J, Rosner B, Simon NM, Wang W, De Vivo I, Okereke OI
Relation of long-term patterns in caregiving activity and depressive symptoms to telomere length in older women
PsychoneuroendocrinologyAbstractBackground: Research links psychological stress to accelerated cellular aging. Here we examined whether long-term patterns of depression and caregiving burden, forms of chronic psychological stress... -
The rationale behind the new Alzheimer’s disease conceptualization: lessons learned during the last decades
Journal of Alzheimer's DiseaseAbstractIn the last decades, progress in neuroimaging techniques and cerebrospinal fluid assays has enabled the characterization of several Alzheimer's disease (AD) biomarkers. This knowledge has shifted the... -
Milne R, Bunnik E, Diaz A, Richard E, Badger S, Gove D, Georges J, Fauria K, Molinuevo JL, Wells K, Ritchie C, Brayne C
Perspectives on Communicating Biomarker-Based Assessments of Alzheimer's Disease to Cognitively Healthy Individuals
Journal of Alzheimer's DiseaseAbstractIn clinical trials which target pathophysiological mechanisms associated with Alzheimer's disease, research participants who are recruited based on biomarker test results should be informed about... -
Busch EL, Crous-Bou M, Prescott J, Downing MJ, Rosner BA, Mutter GL, De Vivo I
Adiponectin, Leptin, and Insulin-Pathway Receptors as Endometrial Cancer Subtyping Markers
Hormones & CancerAbstractDeveloping a system of molecular subtyping for endometrial tumors might improve insight into disease etiology and clinical prediction of patient outcomes. High body mass index (BMI) has been... -
Rojas S, Brugulat-Serrat A, Bargalló N, Minguillón C, Tucholka A, Falcon C, Carvalho A, Morán S, Esteller M, Gramunt N, Fauria K, Camí J, Molinuevo JL, Gispert JD
Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45-75: Results from the ALFA study
Journal of Cerebral Blood Flow & MetabolismAbstractCerebral white matter hyperintensities are believed the consequence of small vessel disease and are associated with risk and progression of Alzheimer's disease. The ɛ4 allele of the APOE gene is the... -
Sanroma G, Benkarim OM, Piella G, Camara O, Wu G, Shen D, Gispert JD, Molinuevo JL, González Ballester MA, Alzheimer’s Disease Neuroimaging Initiative
Learning non-linear patch embeddings with neural networks for label fusion
Medical Image AnalysisAbstractIn brain structural segmentation, multi-atlas strategies are increasingly being used over single-atlas strategies because of their ability to fit a wider anatomical variability. Patch-based label... -
Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Molinuevo JL, Zetterberg H
Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia
JAMA PsychiatryAbstractImportance: Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without... -
Atri A, Frölich L, Ballard C, Tariot PN, Molinuevo JL, Boneva N, Windfeld K, Raket LL, Cummings JL
Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials
JAMAAbstractImportance: New therapeutic approaches for Alzheimer disease (AD) are needed. Objective: To assess whether idalopirdine, a selective 5-hydroxytryptamine-6 receptor antagonist, is effective for... -
Tucholka A, Grau-Rivera O, Falcon C, Rami L, Sánchez-Valle R, Lladó A, Gispert JD, Molinuevo JL, for the Alzheimer’s Disease Neuroimaging Initiative
Structural connectivity alterations along the AD continuum: reproducibility across two independent samples and correlation with CSF Aβ and tau
Journal of Alzheimer's DiseaseAbstractBackground: Gray matter changes associated with the progression of Alzheimer's disease (AD) have been thoroughly studied. However, alterations in white matter tracts have received less attention...
