Publicacions
Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.
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Cacciaglia R, Molinuevo JL, Sánchez-Benavides G, Falcon C, Gramunt N, Brugulat-Serrat A, Grau-Rivera O, Gispert JD
Episodic Memory and Executive Function in cognitively Healthy Individuals Display Distinct Neuroanatomical Correlates which are Differentially Modulated by Aging
Human Brain MappingAbstractThe neuroanatomical bases of episodic memory (EM) and executive functions (EFs) have been widely addressed in patients with brain damage and in individuals with neurologic disorders. These studies... -
Cacciaglia R, Molinuevo JL, Falcón C, Brugulat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillon C, Fauria K, Gispert JD
Impact of APOE genetic variant on brain morphology in a cohort of cognitively healthy middle-aged individuals with enriched genetic risk for Alzheimer’s disease
Alzheimer's DementiaAbstractIntroduction: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains... -
Casamitjana A, Petrone P, Tucholka A, Falcon C, Skouras S, Molinuevo JL, Vilaplana V, Gispert JD, for the Alzheimer's Disease Neuroimaging Initiative
MRI-Based Screening of Preclinical Alzheimer’s Disease for Prevention Clinical Trials
Journal of Alzheimer's DiseaseAbstractThe identification of healthy individuals harboring amyloid pathology represents one important challenge for secondary prevention clinical trials in Alzheimer's disease (AD). Consequently, noninvasive... -
Bos I, Vos S, Vandenberghe R, Scheltens P, Engelborghs S, Frisoni G, Molinuevo JL, Wallin A, Lleó A, Popp J, Martinez-Lage P, Baird A, Dobson R, Legido-Quigley C, Sleegers K, Van Broeckhoven C, Bertram L, Ten Kate M, Barkhof F, Zetterberg H, Lovestone S, Streffer J, Visser PJ
The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics
Alzheimer's Research & TherapyAbstractBackground: There is an urgent need for novel, noninvasive biomarkers to diagnose Alzheimer's disease (AD) in the predementia stages and to predict the rate of decline. Therefore, we set up the... -
Ghaziri J, Tucholka A, Girard G, Boucher O, Houde JC, Descoteaux M, Obaid S, Gilbert G, Rouleau I, Nguyen DK
Subcortical structural connectivity of insular subregions
Scientific ReportsAbstractHidden beneath the Sylvian fissure and sometimes considered as the fifth lobe of the brain, the insula plays a multi-modal role from its strategic location. Previous structural studies have reported... -
Hansson O, Mikulskis A, Fagan AM, Teunissen C, Zetterberg H, Vanderstichele H, Molinuevo JL, Shaw LM, Vandijck M, Verbeek MM, Savage M, Mattsson N, Lewczuk P, Batrla R, Rutz S, Dean RA, Blennow K
The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: A review
Alzheimer's DementiaAbstractIntroduction: Cerebrospinal fluid (CSF) biomarkers have the potential to improve the diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical CSF handling protocols... -
Bos I, Vos SJB, Jansen WJ, Vandenberghe R, Gabel S, Estanga A, Ecay-Torres M, Tomassen J, den Braber A, Lleó A, Sala I, Wallin A, Kettunen P, Molinuevo JL, Rami L, Chetelat G, de la Sayette V, Tsolaki M, Freund-Levi Y, Johannsen P, Alzheimer's Disease Neuroimaging Initiative, Novak GP, Ramakers I, Verhey FR, Visser PJ
Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data
Frontiers in Aging NeuroscienceAbstractWe investigated whether amyloid-β (Aβ) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would... -
Obaid S, Tucholka A, Ghaziri J, Jodoin PM, Morency F, Descoteaux M, Bouthillier A, Nguyen DK
Cortical thickness analysis in operculo-insular epilepsy
Neuroimage: ClinicalAbstractBackground: In temporal lobe epilepsy (TLE), advanced neuroimaging techniques reveal anomalies extending beyond the temporal lobe such as thinning of fronto-central cortices. Operculo-insular epilepsy... -
Grau-Guinea L, Pérez-Enríquez C, García-Escobar G, Arrondo-Elizarán C, Pereira-Cutiño B, Florido-Santiago M, Piqué-Candini J, Planas A, Paez M, Peña-Casanova J, Sánchez-Benavides G
Development, equivalence study, and normative data of version B of the Spanish-language Free and Cued Selective Reminding Test
NeurologíaAbstractIntroduction: The Free and Cued Selective Reminding Test (FCSRT) is widely used for the assessment of verbal episodic memory, mainly in patients with Alzheimer disease. A Spanish version of the FCSRT... -
Palma-Gudiel H, Córdova-Palomera A, Tornador C, Falcón C, Bargalló N, Deco G, Fañanás L
Increased methylation at an unexplored glucocorticoid responsive element within exon 1D of NR3C1 gene is related to anxious-depressive disorders and decreased hippocampal connectivity
European NeuropsychopharmacologyAbstractAmong the major psychiatric disorders, anxious-depressive disorders stand out as one of the more prevalent and more frequently associated with hypothalamic-pituitary-adrenal (HPA) axis abnormalities...
