Publicacions
Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.
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Natalia Vilor-Tejedor, Grégory Operto, Tavia E Evans, Carles Falcon, Marta Crous-Bou, Carolina Minguillón, Raffaele Cacciaglia, Marta Milà-Alomà, Oriol Grau-Rivera, Marc Suárez-Calvet, Diego Garrido-Martín, Sebastián Morán, Manel Esteller, Hieab H Adams, José Luis Molinuevo, Roderic Guigó, Juan Domingo Gispert, ALFA Study
Effect of BDNF Val66Met Polymorphism on Hippocampal Subfield Volumes and Compensatory Interaction with APOE-ε4
Brain Structure and FunctionAbstractBackground: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous...
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Casamitjana A, Vilaplana V, Puch S, Aduriz A, López C, Operto G, Cacciaglia R, Falcón C, Molinuevo JL, Gispert JD
NeAT: A Nonlinear Analysis Toolbox for Neuroimaging
NeuroinformaticsAbstractNeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely...
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Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, Baker L, Belleville S, Brodaty H, Brucki SM, Calandri I, Caramelli P, Chen C, Chertkow H, Chew E, Choi SH, Chowdhary N, Crivelli L, Torre R, Du Y, Dua T, Espeland M, Feldman HH, Hartmanis M, Hartmann T, Heffernan M, Henry CJ, Hong CH, Håkansson K, Iwatsubo T, Jeong JH, Jimenez-Maggiora G, Koo EH, Launer LJ, Lehtisalo J, Lopera F, Martínez-Lage P, Martins R, Middleton L, Molinuevo JL, Montero-Odasso M, Moon SY, Morales-Pérez K, Nitrini R, Nygaard HB, Park YK, Peltonen M, Qiu C, Quiroz YT, Raman R, Rao N, Ravindranath V, Rosenberg A, Sakurai T, Salinas RM, Scheltens P, Sevlever G, Soininen H, Sosa AL, Suemoto CK, Tainta-Cuezva M, Velilla L, Wang Y, Whitmer R, Xu X, Bain LJ, Solomon A, Ngandu T, Carrillo MC.
World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia
Alzheimer's & DementiaAbstractReducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a...
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Silvia Ingala, Linda Mazzai, Carole H Sudre, Gemma Salvadó, Anna Brugulat-Serrat, Viktor Wottschel, Carles Falcon, Grégory Operto, Betty Tijms, Juan Domingo Gispert, José Luis Molinuevo, Frederik Barkhof, ALFA Study
The relation between APOE genotype and cerebral microbleeds in a cognitively unimpaired middle- and late-aged individuals
Neurobiology of AgingAbstractPositive associations between cerebral microbleeds (CMBs) and APOE-ε4 (apolipoprotein E) genotype have been reported in Alzheimer's disease, but show conflicting results. We investigated the effect of...
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Raffaele Cacciaglia, José Luis Molinuevo, Carles Falcón, Eider M Arenaza-Urquijo, Gonzalo Sánchez-Benavides, Anna Brugulat-Serrat, Kaj Blennow, Henrik Zetterberg, Juan Domingo Gispert, ALFA study
APOE-e4 shapes the cerebral organization in cognitively intact individuals as reflected by structural gray matter networks
Cerebral CortexAbstractGray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the...
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Ashton NJ, Hye A, Rajkumar AP, Leuzy A, Snowden S, Suárez-Calvet M, Karikari TK, Schöll M, La Joie R, Rabinovici GD, Höglund K, Ballard C, Hortobágyi T, Svenningsson P, Blennow K, Zetterberg H, Aarsland D
An Update on Blood-Based Biomarkers for non-Alzheimer Neurodegenerative Disorders
Nat Rev NeurolAbstractCerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for...
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Dubbelman MA, Verrijp M, Facal D, Sánchez-Benavides G, Brown LJE, van der Flier WM, Jokinen H, Lee A, Leroi I, Lojo-Seoane C, Milošević V, Molinuevo JL , Pereiro Rozas AX, Ritchie C, Salloway S, Stringer G, Zygouris S, Dubois B, Epelbaum S, Scheltens P, Sikkes SAM.
The Influence of Diversity on the Measurement of Functional Impairment: An International Validation of the Amsterdam IADL Questionnaire in Eight Countries
Alzheimers Dement (Amst)AbstractIntroduction: To understand the potential influence of diversity on the measurement of functional impairment in dementia, we aimed to investigate possible bias caused by age, gender, education, and...
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Crous-Bou M, Gascon M, Gispert JD, Cirach M, Sánchez-Benavides G, Falcon C, Arenaza-Urquijo EM, Gotsens X, Fauria K, Sunyer J, Nieuwenhuijsen MJ, Molinuevo JL
Impact of Urban Environmental Exposures on Cognitive Performance and Brain Structure of Healthy Individuals at Risk for Alzheimer's Dementia
Environ IntAbstractBackground: Air quality might contribute to incidence of dementia-related disorders, including Alzheimer's dementia (AD). The aim of our study is to evaluate the effect of urban environmental...
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Eider M Arenaza-Urquijo, Prashanthi Vemuri
Improving the resistance and resilience framework for aging and dementia studies
Alzheimer's Research & TherapyAbstractBackground: The "resistance vs resilience" to Alzheimer's disease (AD) framework (coping vs avoiding) has gained interest in the field in the last year. In this viewpoint, our effort is (i) to provide...
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Heeman F, Yaqub M, Lopes Alves I, Heurling K, Bullich S, Gispert JD , Boellaard R, Lammertsma AA; AMYPAD Consortium.
Simulating the Effect of Cerebral Blood Flow Changes on Regional Quantification of [ 18 F]flutemetamol and [ 18 F]florbetaben Studies
J Cereb Blood Flow MetabAbstractGlobal and regional changes in cerebral blood flow (CBF) can result in biased quantitative estimates of amyloid load by PET imaging. Therefore, the current simulation study assessed effects of these...
