Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Crous-Bou M, Gascon M, Gispert JD, Cirach M, Sánchez-Benavides G, Falcon C, Arenaza-Urquijo EM, Gotsens X, Fauria K, Sunyer J, Nieuwenhuijsen MJ, Molinuevo JL
Impact of Urban Environmental Exposures on Cognitive Performance and Brain Structure of Healthy Individuals at Risk for Alzheimer's Dementia
Environ IntAbstractBackground: Air quality might contribute to incidence of dementia-related disorders, including Alzheimer's dementia (AD). The aim of our study is to evaluate the effect of urban environmental...
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Cacciaglia R , Molinuevo JL , Falcón C , Arenaza-Urquijo EM , Sánchez-Benavides G , Brugulat-Serrat A, Blennow K, Gispert JD
APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks
Cereb CortexAbstractGray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the...
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Jecmenica Lukic M, Kurz C, Respondek G, Grau-Rivera O , Compta Y, Gelpi E, Troakes C; Barcelona Brain Bank collaborative group, the MDS-endorsed PSP study group, van Swieten JC, Giese A, Roeber S, Arzberger T, Höglinger G.
Copathology in Progressive Supranuclear Palsy: Does It Matter?
Mov DisordAbstractBackground: The influence of concomitant brain pathologies on the progression rate in PSP is unclear. Objectives: To analyze the frequency and severity of copathologies and their impact on the...
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Grau-Rivera O, Operto G, Falcón C, Sánchez-Benavides G, Cacciaglia R, Brugulat-Serrat A, Gramunt N, Salvadó G, Suárez-Calvet M, Minguillon C, Iranzo Á, Gispert JD, Molinuevo JL, ALFA Study
Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
Alzheimer's Research & TherapyAbstractBackground: Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study...
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Brugulat-Serrat A, Salvadó G, Operto G, Cacciaglia R, Sudre CH, Grau-Rivera O, Suárez-Calvet M, Falcon C, Sánchez-Benavides G, Gramunt N, Minguillon C, Fauria K, Barkhof F, Molinuevo JL, Gispert JD, ALFA Study
White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
Human Brain MappingAbstractWhite matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume...
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Plant-Rich Dietary Patterns, Plant Foods and Nutrients, and Telomere Length
Advances in NutritionAbstractThe world's population is aging as a consequence of an increased global life expectancy. Identifying simple strategies to promote healthy aging (i.e., absence of major chronic diseases, preserved...
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Valech N, Sánchez-Benavides G, Tort-Merino A, Coll-Padrós N, Olives J, León M, Falcon C, Molinuevo JL, Rami L
Associations Between the Subjective Cognitive Decline-Questionnaire's Scores, Gray Matter Volume, and Amyloid-β Levels
Journal of Alzheimer's DiseaseAbstractBackground: Exploring the relationship between Alzheimer's disease (AD) biomarkers and subjective cognitive decline (SCD) is needed for better defining its clinical meaning in preclinical AD (preAD)...
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Operto G, Molinuevo JL, Cacciaglia R, Falcon C, Brugulat-Serrat A, Suárez-Calvet M, Grau-Rivera O, Bargalló N, Morán S, Esteller M, ALFA Study, Gispert JD
Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects
Neuroimage: ClinicalAbstractThe apolipoprotein E gene (APOE) ε4 allele has a strong and manifold impact on cognition and neuroimaging phenotypes in cognitively normal subjects, including alterations in the white matter (WM)...
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Brugulat-Serrat A, Salvadó G, Sudre CH, Grau-Rivera O,
Suárez-Calvet M , Falcon C, Sánchez-Benavides G, Gramunt N, Fauria K, Cardoso MJ, Barkhof F, Molinuevo JL, Gispert JD, ALFA StudyPatterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals
Brain Imaging and BehaviorAbstractWhite matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the...
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Falcon C, Monté-Rubio GC, Grau-Rivera O, Suárez-Calvet M, Sánchez-Valle R, Rami L, Bosch B, Haass C, Gispert JD, Molinuevo JL
CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals
Neuroimage: ClinicalAbstractCerebrospinal fluid (CSF) YKL40 and sTREM2 are astroglial and microglial activity biomarkers, respectively. We assessed whether CSF YKL40 and sTREM2 baseline levels are associated with longitudinal...
