Publicacions
Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.
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Ashton NJ, Benedet AL, Molfetta GD, Pola I, Anastasi F, Fernández-Lebrero A, Puig-Pijoan A, Keshavan A, Schott J, Tan K, Simrén J, Gomes BF, Montoliu-Gaya L, Isaacson R, Bongianni M, Tolassi C, Cantoni V, Alberici A, Padovani A, Zanusso G, Pilotto A, Borroni B, Suárez-Calvet M, Blennow K, Zetterberg H.
Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay
Alzheimer's & DementiaAbstractIntroduction: Recent advancements in immunological methods accurately quantify biofluid biomarkers for Alzheimer's disease (AD) pathology. Despite progress, more biomarkers, ideally in blood, are...
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Heo G, Xu Y, Wang E, Ali M, Oh HS, Moran-Losada P, Anastasi F, González Escalante A, Puerta R, Song S, Timsina J, Liu M, Western D, Gong K, Chen Y, Kohlfeld P, Flynn A, Thomas AG, Lowery J, Morris JC, Holtzman DM, Perlmutter JS, Schindler SE, Vilor-Tejedor N, Suárez-Calvet M, García-González P, Marquié M, Fernández MV, Boada M, Cano A, Ruiz A, Zhang B, Bennett DA, Benzinger T, Wyss-Coray T, Ibanez L, Sung YJ, Cruchaga C.
Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer's disease
Nature AgingAbstractProteomic studies have been instrumental in identifying brain, cerebrospinal fluid and plasma proteins associated with Alzheimer's disease (AD). Here, we comprehensively examined 6,905 aptamers...
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Alessiani M, Bonura A, Iaccarino G, Rossi SS, Mangiardi M, Bravi MC, Pezzella FR, de Rubeis G, Pampana E, Anticoli S.
Safety and efficacy of mechanical thrombectomy in distal medium vessel occlusions: Experience and real-world data from an Italian stroke hub centre
Journal of stroke and cerebrovascular diseasesAbstractBackground and purpose: Distal-medium vessel occlusions (DMVOs) contribute to approximately 25-40 % of cases of ischemic stroke. Intravenous thrombolysis (IVT) achieved a complete recanalization in...
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Cumplido-Mayoral I, Sánchez-Benavides G, Vilor-Tejedor N, López-Martos D, Brugulat-Serrat A, Milà-Alomà M, Falcon C, Cacciaglia R, Minguillón C, Fauria K, Kollmorgen G, Quijano-Rubio C, Molinuevo JL, Grau-Rivera O, Suárez-Calvet M, Vilaplana V, Gispert JD
Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers.
Molecular PsychiatryAbstractMagnetic resonance Imaging (MRI)-derived brain-age prediction is a promising biomarker of biological brain aging. Accelerated brain aging has been found in Alzheimer's disease (AD) and other...
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Palmqvist S, Warmenhoven N, Anastasi F, Pilotto A, Janelidze S, Tideman P, Stomrud E, Mattsson-Carlgren N, Smith R, Ossenkoppele R, Tan K, Dittrich A, Skoog I, Zetterberg H, Quaresima V, Tolassi C, Höglund K, Brugnoni D, Puig-Pijoan A, Fernández-Lebrero A, Contador J, Padovani A, Monane M, Verghese PB, Braunstein JB, Kern S, Blennow K, Ashton NJ, Suárez-Calvet M, Hansson O.
Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform
Nature MedicineAbstractGlobal implementation of blood tests for Alzheimer's disease (AD) would be facilitated by easily scalable, cost-effective and accurate tests. In the present study, we evaluated plasma phospho-tau217...
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Palpatzis E, Akinci M, Garcia-Prat M, Blennow K, Zetterberg H, Quijano-Rubio C, Kollmorgen G, Wild N, Gispert JD, Suárez-Calvet M, Grau-Rivera O, Fauria K, Brugulat-Serrat A, Sanchez-Benavides G, Arenaza-Urquijo EM; ALFA stydy
Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes
NeurologyAbstractBackground and objectives: The prevalence and impact of stressful life events (SLEs) on age-related and Alzheimer disease (AD)-related pathways may depend on social determinants including gender and...
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Anastasi F, Fernández-Lebrero A, Ashton NJ, Ortiz-Romero P, Torres-Torronteras J, González-Escalante A, Milà-Alomà M, Contador J, García-Escobar G, Manero-Borràs RM, Navalpotro-Gómez I, Jiménez-Moyano E, Sahajan A, Hao Q, Zhang B, Jeromin A, Le Bastard N, Nadal A, Mousavi T, Kollmorgen G, Carboni M, Grau-Rivera O, Zetterberg H, Del Campo M, Blennow K, Puig-Pijoan A, Suárez-Calvet M.
A head-to-head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic
Alzheimer's & DementiaAbstractIntroduction: Blood-based biomarkers for Alzheimer's disease (AD) have been widely studied, but direct comparisons of several biomarkers in clinical settings remain limited.
Methods: In this cross...
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Cacciaglia R, Falcón C, Benavides GS, Brugulat-Serrat A, Alomà MM, Calvet MS, Molinuevo JL, Fauria K, Minguillón C, Kollmorgen G, Quijano-Rubio C, Blennow K, Zetterberg H, Lorenzini L, Wink AM, Ingala S, Barkhof F, Ritchie CW, Gispert JD
Soluble Aβ pathology predicts neurodegeneration and cognitive decline independently on p-tau in the earliest Alzheimer's continuum: Evidence across two independent cohorts
Alzheimer's & DementiaAbstractIntroduction: Identifying the link between early Alzheimer's disease (AD) pathological changes and neurodegeneration in asymptomatic individuals may lead to the discovery of preventive strategies. We...
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Biel D, Suárez-Calvet M, Dewenter A, Steward A, Roemer SN, Dehsarvi A, Zhu Z, Pescoller J, Frontzkowski L, Kreuzer A, Haass C, Schöll M, Brendel M, Franzmeie
Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease
EMBO Molecular MedicineAbstractIn Alzheimer's disease (AD), Aβ triggers p-tau secretion, which drives tau aggregation. Therefore, it is critical to characterize modulators of Aβ-related p-tau increases which may alter AD...
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Argiris G, Akinci M, Peña-Gómez C, Palpatzis E, Garcia-Prat M, Shekari M, Blennow K, Zetterberg H, Kollmorgen G, Quijano-Rubio C, Ashton NJ, Karikari TK, Brinkmalm-Westman A, Lantero-Rodriguez J, Fauria K, Sánchez-Benavides G, Grau-Rivera O, Suárez-Calvet M, Arenaza-Urquijo EM.
Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer's disease
Alzheimer's Research & TherapyAbstractBackground: Cerebrospinal fluid (CSF) biomarkers of synaptic dysfunction, neuroinflammation, and glial response, complementing Alzheimer's disease (AD) core biomarkers, have improved the...
