Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.
Brigos-Barril E, Vasallo C, Farré X, Morcillo-Suárez C, Polo-Alonso S, Rodríguez-Fernández B, Valenzuela A, Sarabia C, Bosch E, Laayouni H, Vilor-Tejedor N, Navarro A, Muntané G
Genetic variants that increase the risk for complex diseases persist in human populations, despite adverse effects on health and longevity. Life-history theory predicts that such alleles can be...
Legaz A, Moguilner S, Barttfeld P, Cuadros Castro J, Galván Rial DS, Migeot J, Farina FR, Gonzalez-Gomez R, Salazar-Londoño S, de Souza Azzi T, Alcauter S, Amoruso L, Anghinah R, Bakr M, Behrens MI, Bruno MA, Cardona JF, Chen C, Colliot O, Custodio N, d'Acremont Q, Debette S, Dzianok P, Güntekin B, Huguet J, Jarne C, Joliot M, Karageorgiou E, Khedr EM, Koopowitz SM, Kublik E, Lee J, Aksman L, Lopez S, Margaretic P, Matallana D, Matis S, Miltiadous A, Novotni G, Orio P, Parra MA, Reppermund S, de Paula França Resende E, Salum GA, Slachevsky A, Ortiz ALS, Takada LT, Toh AQ, Tzallas A, Wen W, Whelan R, Yener G, Zegarra Valdivia JA, Alexoudi A, Arshad F, Atta H, Avila-Funes JA, Santos JB, Bruña R, Castelblanco-Toro SM, Chino Vilca BN, Coronel-Oliveros C, Crivello F, Cruzat J, Dellavale D, Dhooge C, Di Caterina G, Escudero J, Esquivias Farias JM, Eze LU, Evans TE, Farombi T, Fernández A, Fittipaldi S, Portillo F, Martinic GF, García AM, Garcia-Cordero I, Gaurav R, Godoy ME, Gonzalez Campo C, González Hernández A, Hanoğlu L, Hazelton JL, Herzog R, Ikiz B, Njamnshi AK, Landin-Romero R, López ME, Maito MA, Medel V, Sepúlveda JPM, Ochoa Gómez JF, Ogbuagu C, de Oliveira MO, Ozansoy M, Palma-Espinosa J, Hilal S, Zhou JH, Escudero SDP, Pitman JK, Prado P, Ramírez González D, Reyes P, Santamaría García H, Schröder J, Sitt JD, Soliman RK, Soto-Añari M, Thanissery N, Ito LT, Tsuchida A, Tzourio C, Yırıkoğulları H, Yokoyama JS, Aguillon D, Miller B, Alladi S, Jiang Y, Navarro A, Babiloni C, Huepe Artigas D, Piguet O, Sosa PAV, Mostert CM, Tahmasian M, Li P, Hu K, Genon S, Stein DJ, Maestú F, Pievani M, Salama M, Brodaty H, Sachdev PS, Lawlor B, Eyre HA, Miranda JJ, Baez S, Tagliazucchi E, Duran-Aniotz C, Hernandez H, Ibanez A.
The physical and social exposome affects human aging, and brain clocks may track its effects. However, most studies neglect multidomain exposures (physical, social and political) across diverse...
Genius P, Fernández-Bonet A, Rodríguez-Fernández B, Gallay C, Gonzalez-Escalante A, Sánchez-Benavides G, López-Martos D, Esteller M, Navarro A, Gispert JD, Brugulat-Serrat A, Vilor-Tejedor N
Alzheimer's disease (AD) is a progressive neurodegenerative condition in which genetic predisposition plays a key role, yet the sex-specific mechanisms linking genetic risk to early cognitive changes...
Santos-Pujol E, Noguera-Castells A, Casado-Pelaez M, García-Prieto CA, Vasallo C, Campillo-Marcos I, Quero-Dotor C, Crespo-García E, Bueno-Costa A, Setién F, Ferrer G, Davalos V, Mereu E, Pluvinet R, Arribas C, Torre C, Villavicencio F, Sumoy L, Granada I, Coles NS, Acha P, Solé F, Mallo M, Mata C, Peregrina S, Gabaldón T, Llirós M, Pujolassos M, Carreras-Torres R, Lluansí A, García-Gil LJ, Aldeguer X, Samino S, Torné P, Ribalta J, Guardiola M, Amigó N, Yanes O, Martínez P, Sánchez-Vázquez R, Blasco MA, Oviedo J, Lemos B, Rius-Bonet J, Torrubiano M, Massip-Salcedo M, Khidir KA, Cao TH, Quinn PA, Jones DJL, Macip S, Brigos-Barril E, Moldes M, Barteri F, Muntané G, Laayouni H, Navarro A, Esteller M.
Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have...
Carmona R, Roldán G, Fernández-Rueda JL, Navarro A, Peña-Chilet M; CSVS Crowdsourcing Group; Dopazo J, López-López D.
Here we present the Polygenic Score (PGS) distributions for 3124 common diseases and quantitative traits observed in the Spanish population. To achieve so, the genomes and exomes of 2190 unrelated...
García-Lezana T, Bobowicz M, Frid S, Rutherford M, Recuero M, Riklund K, Cabrelles A, Rygusik M, Fromont L, Francischello R, Neri E, Capella S, Navarro A, Prior F, Bona J, Nicolas P, Starmans MPA, Lekadir K, Rambla J.
Background: An unprecedented amount of personal health data, with the potential to revolutionize precision medicine, is generated at health care institutions worldwide. The exploitation of such data...
Rodríguez-Fernández B, Sánchez-Benavides G, Genius P, Minguillon C, Fauria K, De Vivo I, Navarro A, Molinuevo JL, Gispert JD, Sala-Vila A, Vilor-Tejedor N, Crous-Bou M.
Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the...
Fiore L, Arderiu J, Martí-Sarrias A, Turpín I, Pareja RI, Navarro A, Holubiec M, Bianchelli J, Falzone T, Spelzini G, Scicolone G, Acosta S
Engrafting organoids into vascularized tissues in model animals, such as the immunodeficient mouse or chick embryo chorioallantoic membrane (CAM), has proven efficient for neovascularization modeling...
He R, Al-Tamimi J, Sánchez-Benavides G, Montaña-Valverde G, Domingo Gispert J, Grau-Rivera O, Suárez-Calvet M, Minguillon C, Fauria K, Navarro A, Hinzen W
Abnormal deposition of Aβ amyloid is an early neuropathological marker of Alzheimer's disease (AD), arising long ahead of clinical symptoms. Non-invasive measures of associated early neurofunctional...
Vilor-Tejedor N, Genius P, Rodríguez-Fernández B, Minguillón C, Sadeghi I, González-Escalante A, Crous-Bou M, Suárez-Calvet M, Grau-Rivera O, Brugulat-Serrat A, Sánchez-Benavides G, Esteller M, Fauria K, Molinuevo JL, Navarro A, Gispert JD
Introduction: In 2013, the ALzheimer's and FAmilies (ALFA) project was established to investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster research on early...