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publicaciones

Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.

  • Vilor-Tejedor N, van Vorstenbosch R, Evans TE

    Artificial intelligence in dementia care: challenges, controversies, and policy implications

    Frontiers in Dementia
    Abstract

    Artificial intelligence (AI) is rapidly expanding into dementia-related health and social care, with proposed applications ranging from early risk detection and monitoring to care coordination and...

  • Legaz A, Moguilner S, Barttfeld P, Cuadros Castro J, Galván Rial DS, Migeot J, Farina FR, Gonzalez-Gomez R, Salazar-Londoño S, de Souza Azzi T, Alcauter S, Amoruso L, Anghinah R, Bakr M, Behrens MI, Bruno MA, Cardona JF, Chen C, Colliot O, Custodio N, d'Acremont Q, Debette S, Dzianok P, Güntekin B, Huguet J, Jarne C, Joliot M, Karageorgiou E, Khedr EM, Koopowitz SM, Kublik E, Lee J, Aksman L, Lopez S, Margaretic P, Matallana D, Matis S, Miltiadous A, Novotni G, Orio P, Parra MA, Reppermund S, de Paula França Resende E, Salum GA, Slachevsky A, Ortiz ALS, Takada LT, Toh AQ, Tzallas A, Wen W, Whelan R, Yener G, Zegarra Valdivia JA, Alexoudi A, Arshad F, Atta H, Avila-Funes JA, Santos JB, Bruña R, Castelblanco-Toro SM, Chino Vilca BN, Coronel-Oliveros C, Crivello F, Cruzat J, Dellavale D, Dhooge C, Di Caterina G, Escudero J, Esquivias Farias JM, Eze LU, Evans TE, Farombi T, Fernández A, Fittipaldi S, Portillo F, Martinic GF, García AM, Garcia-Cordero I, Gaurav R, Godoy ME, Gonzalez Campo C, González Hernández A, Hanoğlu L, Hazelton JL, Herzog R, Ikiz B, Njamnshi AK, Landin-Romero R, López ME, Maito MA, Medel V, Sepúlveda JPM, Ochoa Gómez JF, Ogbuagu C, de Oliveira MO, Ozansoy M, Palma-Espinosa J, Hilal S, Zhou JH, Escudero SDP, Pitman JK, Prado P, Ramírez González D, Reyes P, Santamaría García H, Schröder J, Sitt JD, Soliman RK, Soto-Añari M, Thanissery N, Ito LT, Tsuchida A, Tzourio C, Yırıkoğulları H, Yokoyama JS, Aguillon D, Miller B, Alladi S, Jiang Y, Navarro A, Babiloni C, Huepe Artigas D, Piguet O, Sosa PAV, Mostert CM, Tahmasian M, Li P, Hu K, Genon S, Stein DJ, Maestú F, Pievani M, Salama M, Brodaty H, Sachdev PS, Lawlor B, Eyre HA, Miranda JJ, Baez S, Tagliazucchi E, Duran-Aniotz C, Hernandez H, Ibanez A.

    The exposome of brain aging across 34 countries

    Nature Medicine
    Abstract

    The physical and social exposome affects human aging, and brain clocks may track its effects. However, most studies neglect multidomain exposures (physical, social and political) across diverse...

  • Rehman D, Chen HY, Lee CC, Vilor-Tejedor N, Upadhyay S, Kuo PC.

    Diffusion-synthesized Chest X-rays improve fairness and diagnostic performance

    PLOS Digital Health
    Abstract

    Deep learning models have been widely applied to chest X-ray (CXR) disease classification and diagnosis; however, challenges such as data scarcity and shortcut learning often lead to biased model...

  • Mattsson-Carlgren N, Palmqvist S, Horie K, Barthélemy N, Salvadó G, Binette AP, Tideman P, Morris JC, Benzinger TL, Perrin RJ, Janelidze S, Collij LE, Ossenkoppele R, Schindler SE, Stomrud E, Bateman RJ, Hansson O.

    Integration of plasma eMTBR-tau243 and p-tau217 in the diagnosis and stratification of Alzheimer's disease: a prospective cohort study

    The Lancet Neurology
    Abstract

    Background: Alzheimer's disease pathology can be accurately identified with blood biomarkers (core 1 biomarkers), including plasma p-tau217 tests. Biomarkers that change longitudinally after diagnosis...

  • Hortsch S, Domenico AD, Borlinghaus N, Caley D, Kaminioti-Dumont L, Jeppesen SB, González-Escalante A, Ritchie C, Frederiksen KS, Suárez-Calvet M.

    Performance of a fully automated plasma tau phosphorylated at threonine 217 immunoassay to reflect amyloid-beta burden in an unselected cohort representative of clinical practice

    The journal of prevention of Alzheimer's Disease
    Abstract

    Background: With the emergence of disease-modifying anti-amyloid-beta (Aβ) therapies for Alzheimer's disease (AD), early and accurate quantitative measures of Aβ burden are critical. Blood-based...

  • Salemme S, Mukadam N, Bodryzlova Y, Blossom SCM, Brayne C, Richard E, Seshadri S, Ma'u E, Akinyemi RO, Urso D, Wolters FJ, Grasset L, Dufouil C, Ferri CP, Langa KM, Kalaria R, McKenzie BL, Röhr S, Ibáñez A, Lautenschlage NT, Cullum S, Bobrow K, Anstey KJ, Wallace L, Walsh S; PLADRR Research Group.

    Operationalising dementia prevention as a measurable NCD priority

    The Lancet. Public Health
    Abstract

    Not available

  • Reiman EM, Alexander RC, Langbaum JB, Aisen PS, Ashton N, Atri A, Barbarino P, Byrd GS, Feldman HH, Fowler NR, Ghisays V, Grill JD, Hassenstab J, Heaton GR, Herring WL, Jack CR Jr, Johnson SC, Karlawish J, Keach NL, Kivipelto M, Krumholz HM, Largent EA, MaGee-Rodgers T, McDade E, Mielke MM, Molina-Henry D, Petersen RC, Rabinovici GD, Ritchie C, Schindler SE, Sperling RA, Suárez-Calvet M, Vradenburg G, Weiner MW, Welsh-Bohmer KA, Zetterberg H, Zuendel MT, Mattke S, Cummings JL

    A path to preventing cognitive impairment due to Alzheimer's disease: initiatives beginning in the USA

    The Lancet Neurology
    Abstract

    Antibody therapies can remove amyloid plaques from the brain and slow cognitive decline in people with Alzheimer's disease who are mildly impaired. These drugs are now being evaluated in participants...

  • Suemoto CK, Custodio N, Aguilar D, Avila-Funes JA, Baez S, Bagnati PM, Barnes LL, Brucki SMD, Calandri IL, Caramelli P, Cornejo-Olivas M, Derio CD, Ferreira ST, García AM, Grinberg LT, Ibanez AM, Isasi R, Josephy-Hernández SE, Porras ML, Llibre-Guerra JJ, Llibre-Rodriguez JJ, Lourenco MV, Meza BMM, Migeot J, Miranda JJ, Miranda-Castillo C, Mummery CJ, Parodi JF, Castro NP, Contreras RMS, Santamaría-García H, Slachevsky A, Souza-Talarico JN, Surace EI, Takada LT, Tsoy E, Pilalumbo MU, Zimmer ER, Fontana IC, Mahinrad S, Snyder HM, Carrillo MC.

    The landscape of dementia research, diagnosis, treatment, and care in Latin America

    Alzheimer's & Dementia
    Abstract

    Latin America is undergoing rapid population aging alongside a rising burden of dementia. While the region holds substantial potential for dementia risk reduction, challenges remain, such as delayed...

  • Daly T, López-Barrenechea I, Vergara P, Arshad F, Paplikar A, Ray Chaudhuri A, Crivelli L, Ibáñez A, Alladi S, Slachevsky A.

    Scientific knowledge about dementia: From the Global South to the world

    Alzheimer's & Dementia
    Abstract

    Most people with dementia live in low- and middle-income countries (LMICs), but scientific knowledge about dementia is dominated by Global North perspectives. This interdisciplinary article combines...

  • Timsina J, Jiang C, McCartney DL, Tao F, Dalmasso MC, Najar J, Anastasi F, Ohlei O, Puerta Fuentes R, Yang C, Bradley J, Western D, Ali M, Wang C, Yang C, Wu Y, Liu M, Budde J, Williams J, Mahoney R, Castillo Morales A, Hohman TJ, Dumitrescu L, Wang TC, Tesi N, Kern S, Waern M, Skoog I, van Harten A, Pijnenburg YAL, van der Flier WM, Sánchez-Juan P, Rodriguez-Rodriguez E, Kleineidam L, Peters O, Schneider A, Küçükali F, Bellenguez C, Grenier-Boley B, Heikkinen S, de Rojas I, Rujescu D, Scherbaum N, Hausner L, Düzel E, Grimmer T, Wiltfang J, Vandenberghe R, Engelborghs S, Heilmann-Heimbach S, Schmid M, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, Pérez-Tur J, Bullido MJ, Sánchez-Valle R, Álvarez V, García-González P, Mir P, Real LM, Piñol-Ripoll G, García-Alberca JM, Seelaar H, Ramakers I, Papma J, Hulsman M, Laske C, Teipel S, Priller J, Perneczky R, Buerger K, Nöthen MM, Lewczuk P, Kornhuber J, Hampel H, Giegling I, Goldhardt O, Diehl-Schmid J, Andrade V, Heneka MM, Frölich L, Vogelgsang J, Graff C, Thonberg H, Ullgren A, Papenberg G, Deleuze JF, Dufouil C, Wagner M, Jessen F, Holstege H, van Duijn C, Lebouvier T, Hannon O, Leinonen V, Soininen H, Herukka SK, Giedraitis V, Löwenmark M, Kilander L, Genius P, Rodríguez B, Luckett ES, Navarro A, Cano A, Marquié M, Blennow K, Zetterberg H, Lleo A, Boada M, Ruiz A, Lee VM, Van Deerlin VM, Deming Y, Johnson SC, Engelman CD, Pastor P, Alvarez I, Peskind ER, Heslegrave AJ, Saykin AJ, Nho K, Schindler SE, Morris JC, Holtzman DM, McDade E, Renton AE, Goate A, Ibanez L, Riemenschneider M, Albert MS, Laws SM, Porter T, O'Brien EK, Shaw LM, Tijms BM, Ingelsson M, Visser PJ, Hiltunen M, Sleegers K, Ritchie CW, Sims R, Belloy M, Lambert JC, Vilor-Tejedor N, Fernández MV, Li QS, Nagle MW, Marioni RE, Ramirez A, Bertram L, van der Lee SJ, Cruchaga C. 

    GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy

    Nature Communications
    Abstract

    Cerebrospinal fluid amyloid beta 42, total tau, and phosphorylated tau 181 are well accepted markers of Alzheimer's disease. These biomarkers better reflect disease pathogenesis compared to clinical...