Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Robles V, Valentí M, Mendibe M, Hidalgo Á, Albamonte F, Berrocoso E, Lara M, Calvo R, López C, Deshpande O, Palma-Gudiel H, Benito G, Díaz Marsa M, Parellada M, Dierssen M
Promoting brain health across the lifespan: Socioeconomic burden, global recommendations, and the Spanish national plan
Neuroscience AppliedAbstractNeurological and mental health disorders substantially reduce life expectancy and represent a major public health and socioeconomic burden in Europe, accounting for a significant proportion of...
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Pérez-García G, Gallart-Gallego L, Comps-Vicente O, Molto-García L, Grau-Rivera O, Pradas-Méndez S, Soteras-Prat A, Montes-Pérez A.
Protocol to avoid post-dural puncture headache after large-volume cerebral spinal fluid extraction in a prospective observational memory clinic study
Scientific ReportsAbstractLumbar puncture (LP) to extract cerebral spinal fluid (CSF) to quantify analytes relevant to brain health can lead to post-dural puncture headache (PDPH). Incidences vary across studies. This...
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Ibáñez A, Duran-Aniotz C, Migeot J, Báez S, Fittipaldi S, Coronel-Oliveros C, Eyre HA, Udeh-Momoh C, Zetterberg H, Alladi S, Sandi C, Robertson IH, Franzen S, Farombi T, Montalvo Ortiz JL, Seshadri S, Court F, Valdes-Sosa P, Xu J, Yu C, Grinberg L, Lawlor B, Sachdev PS, Yaffe K, Hachinski V, Friston K, Tagliazucchi E, Santamaría-García H.
Computational whole-body-exposome models for global precision brain health
Nature CommunicationsAbstractThe worldwide rise of neurological and psychiatric conditions poses major challenges. However, current global research remains fragmented, dominated by limited cohorts and poorly integrated datasets...
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Xia X, Eriksdotter M, Zetterberg H, Kern S, Skillbäck T, Blasi MT, Winblad B, Mak JKL, Ornago AM, Pinardi E, Romero Ortuño R, Jönsson L
Frailty and prognosis of biomarker-confirmed Alzheimer's disease: a Swedish, register-based, retrospective cohort study
The Lancet Healthy LongevityAbstractBackground: This study aimed to examine the value of frailty status (defined by the frailty index) in informing the prognosis of people living with Alzheimer's disease.
Methods: In this retrospective...
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International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative
Alzheimer's Research & TherapyAbstractBackground: Socio-cognitive assessment in neurocognitive disorders (NCDs) is rare in clinical practice and no consensus exists as to a uniform operationalization of socio-cognitive measures for NCDs...
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Borràs E, Anastasi F, Pastor O, Suárez-Calvet M, Sabidó E
Enhanced proteome profiling of human cerebrospinal fluid using a commercial plasma enrichment strategy
Journal of proteomicsAbstractCerebrospinal fluid (CSF) is a valuable liquid biopsy for identifying protein biomarkers in neurological diseases, yet its proteome profiling faces challenges due to the large dynamic range of protein...
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Pahlke S, Kahale LA, Mahinrad S, Sousa-Pinto B, Vieira RJ, McAteer MB, Claessen T, Contador J, Hofmann A, Kuchenbecker LA, Machado LS, Warmenhoven N, Yakoub Y, Palmqvist S, Schindler SE, Teunissen C, Whitson HE, Zetterberg H, Edelmayer R, Tampi MP
Blood-based biomarkers for detecting Alzheimer's disease pathology in cognitively impaired individuals within specialized care settings: A systematic review and meta-analysis
Alzheimer's & DementiaAbstractBackground: This systematic review and meta-analysis aimed to assess the diagnostic test accuracy of blood-based biomarkers (BBMs) for detecting Alzheimer's disease (AD) pathology in cognitively...
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Gregory S, Bridgeman K, Darwin H, Barbato M, Booi L, Brugulat Serrat A, Chadha AS, Farina FR, Jenkins N, Jutila OI, Low A, Marongiu R, Naci L, Pulford P, Ritchie CW, Ritchie K, Udeh-Momoh C, Watermeyer T, Welstead M, Muniz-Terrera G
Associations of estrogen with modifiable and non-modifiable risk factors for dementia: A narrative review
Alzheimer's & DementiaAbstractFemale sex is associated with higher incidence and risk of dementia. Estrogen may represent one important mechanism contributing to the increase in incidence rates. In this review, we synthesize...
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Pieperhoff L, Lorenzini L, Mastenbroek S, Tranfa M, Shekari M, Wink AM, Wolz R, Grootoonk S, Ritchie C, Boada M, Marquié M, van der Flier W, Vandenberghe R, Hanseeuw BJ, Martínez-Lage P, Payoux P, Visser PJ, Schöll M, Frisoni GB, Stephens A, Buckley C, Farrar G, Jessen F, Grau-Rivera O, Gispert JD, García DV, Mutsaerts H, Barkhof F, Collij LE
Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study
Neuroimage: ClinicalAbstractThe impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer's disease (AD), and its interaction with risk factors like sex and APOE-ε4 carriership, remains unclear. In...
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Tranfa M, Pieperhoff L, Pontillo G, Luckett ES, Collij LE, Oliveira TG, Tesi N, Vilor-Tejedor N, Altmann A, Roccatagliata L, Pardini M, Holstege H, Reinders M, Payoux P, Martinez-Lage P, Ritchie CW, Waldman A, Wardlaw JM, Gispert JD, Salvadó G, Brunetti A, Mutsaerts HJMM, Wink AM, Barkhof F, Lorenzini L
Polygenic pathways shape white matter vulnerability to Alzheimer's disease-related pathophysiological changes
Alzheimer's Research & TherapyAbstractBackground: The accumulation of amyloid-β1-42 (Aβ1-42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer's disease (AD) has led to a biological definition...
