Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Anastasi F, Genius P, Rodriguez-Fernandez B, Yang C, Gorijala P, Timsina J, Hernández-Villamizar F, Lorenzini L, Del Campo M, Sánchez-Benavides G, Minguillon C, Navarro A, Cruchaga C, Suárez-Calvet M, Vilor-Tejedor N.
Proteomic polygenic risk scores of age-related plasma protein levels reveal a role for Metalloproteinase inhibitor 2 (TIMP2) in cognitive performance
Neurobiology of AgingAbstractSeveral studies in mice have identified blood proteins that influence brain aging, yet translating these findings into humans remains challenging. To address this gap, we conducted a systematic review...
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Lorenzini L, Tranfa M, Pieperhoff L, Masserini F, Ten Kate M, Collij LE, Pontillo G, Luckett ES, Wink AM, Mutsaerts HJ, Oliveira TG, Altomare D, Boada M, den Braber A, Birck C, Buckley C, Farrar G, van der Flier W, Frisoni GB, Gismondi R, Gispert JD, Hanseeuw BJ, Jessen F, Marquié M, Mett A, Ritchie C, Salvadó G, Schöll M, Shekari M, Stephens AW, Tijms BM, Vállez García D, Vandenberghe R, Visser PJ, Roccatagliata L, Oxtoby NP, Pardini M, Barkhof F.
Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning
Alzheimer's & DementiaAbstractIntroduction: The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear.
Methods: We analyzed data from 1323 individuals without a diagnosis of...
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Lara-Simon E, Gispert JD, Garcia-Ojalvo J, Villoslada P.
Multiscale networks in Alzheimer's disease identify brain hypometabolism as central across biological scales
PLoS Computational BiologyAbstractAlzheimer's disease encompasses multiple biological scales, spanning molecular factors, cells, tissues, and behavioral manifestations. The interplay among these scales in shaping the clinical...
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Muñoz-García MI, Deming Y, Lugo-Hernández F, Johnson S, Asthana S, Kollmorgen G, Quijano-Rubio C, Carlsson C, Okonkwo OC, Pérez-Martinez D, Villarejo-Galende A, Blennow K, Suárez-Calvet M, Zetterberg H, Bendlin BB, Morenas-Rodríguez E
Synaptic dysfunction and glial activation markers throughout aging and early neurodegeneration: a longitudinal CSF biomarker-based study
Molecular NeurodegenerationAbstractBackground: Synaptic homeostasis, maintained by microglia and astroglia, is disrupted throughout aging and early on in neurodegenerative diseases. Our aim was to study the relationship between TREM2...
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Karlsson L, Janelidze S, Barthélemy NR, Horie K, Therriault J, Gaetani L, Bellomo G, Schindler SE, Vogel J, Arvidsson I, Åström K, Gordon BA, Raji CA, Benzinger TLS, Morris JC, Nilsson J, Brinkmalm A, Palmqvist S, Stomrud E, Salvadó G, Pichet Binette A, Di Filippo M, Parnetti L, Rosa-Neto P, Blennow K, Bateman RJ, Mattsson-Carlgren N, Hansson O.
Reference proteins to improve Core 1 and Core 2 Alzheimer's disease CSF and plasma biomarkers
Brain: a journal of neurologyAbstractConcentration-based fluid biomarkers represent an informative and cost-effective way to detect and monitor Alzheimer's disease (AD) pathology. However, non-AD-related inter-individual variation in...
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Bonet N, Mascaro JM Jr, Hurtado-Navarro L, Angosto-Bazarra D, Callejas-Rubio JL, Clemente D, Souto A, Lima O, Palmou-Fontana N, Baselga E, Jiménez-Treviño S, Remesal A, Andreu-Barasoain M, Fernandez-Dominguez L, Riera-Monroig J, Aparicio M, Garcia-Herrero J, Pesqué D, Sanchez-Calvin MT, Lezana-Rosales JM, Correyero-Plaza M, Garcia-Villalba J, Bolaño V, Peiro S, Diaz M, Vlagea A, Lorca D, Fabregat V, Anton MC, Plaza S, Gonzalez-Granado LI, Postigo C, de Morales JMG, de la Fuente EG, Iglesias E, Gomez-Roman J, Vázquez-Triñanes C, Lopez-Robledillo JC, Ortego-Centeno N, Giménez-Arnau AM, Campistol JM, Laayouni H, de Landazuri IO, Yagüe J, Gonzalez-Roca E, Mensa-Vilaro A, Fornas O, Ramos E, Pelegrin P, Casals F, Arostegui JI
Novel Insights into the Clinical Features, Genetic Spectrum and Clonal Evolution of Patients Carrying NLRP3 Mosaicism
Journal of clinical immunologyAbstractNLRP3 mosaicism is a well-established mechanism causing the monogenic autoinflammatory disease named cryopyrin-associated periodic syndromes (CAPS). The number of reported patients with NLRP3...
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Lázaro I, Brugulat-Serrat A, Suárez-Calvet M, Fauria K, Minguillon C, Gispert JD, Molinuevo JL, Harris WS, Sánchez-Benavides G, Grau-Rivera O, Sala-Vila A
Red blood cell omega-3 status and longitudinal cognition in individuals at risk of Alzheimer's disease
The Journal of NutritionAbstractBackground: Many observational studies on dietary omega-3 fatty acids (FAs) and cognition focused on docosahexaenoic acid (DHA), because its significant role in brain. There is growing interest in...
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Santos-Pujol E, Noguera-Castells A, Casado-Pelaez M, García-Prieto CA, Vasallo C, Campillo-Marcos I, Quero-Dotor C, Crespo-García E, Bueno-Costa A, Setién F, Ferrer G, Davalos V, Mereu E, Pluvinet R, Arribas C, Torre C, Villavicencio F, Sumoy L, Granada I, Coles NS, Acha P, Solé F, Mallo M, Mata C, Peregrina S, Gabaldón T, Llirós M, Pujolassos M, Carreras-Torres R, Lluansí A, García-Gil LJ, Aldeguer X, Samino S, Torné P, Ribalta J, Guardiola M, Amigó N, Yanes O, Martínez P, Sánchez-Vázquez R, Blasco MA, Oviedo J, Lemos B, Rius-Bonet J, Torrubiano M, Massip-Salcedo M, Khidir KA, Cao TH, Quinn PA, Jones DJL, Macip S, Brigos-Barril E, Moldes M, Barteri F, Muntané G, Laayouni H, Navarro A, Esteller M.
The multiomics blueprint of the individual with the most extreme lifespan
Cell Reports MedicineAbstractExtreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have...
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Luckett ES, Abakkouy Y, Lorenzini L, Collij LE, Garcia DV, Visser PJ, den Braber A, Ritchie C, Boada M, Genius P, Vilor-Tejedor N, Gispert JD, Vandenberghe R, Barkhof F, Cleynen I
Harmonizing genotype array data to understand genetic risk for brain amyloid burden in the AMYPAD PNHS Consortium
Alzheimer's & DementiaAbstractIntroduction: We sought to harmonize genotype data from the predementia AMYPAD (Amyloid Imaging to Prevent Alzheimer's Disease) Consortium, compute polygenic risk scores (PRS), and determine their...
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Ottoy J, Owsicki N, Bilgel M, Binette AP, Salvadó G, Kang MS, Cash DM, Ewers M, La Joie R, Wisse LEM, Goubran M, Betthauser T
Recent advances in neuroimaging of Alzheimer's disease and related dementias
Alzheimer's & DementiaAbstractThis review covers recent advances (2023-2024) in neuroimaging research into the pathophysiology, progression, and treatment of Alzheimer's disease (AD) and related dementias (ADRD). Despite the rapid...
