Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Frisoni GB, Boccardi M, Barkhof F, Blennow K, Cappa S, Chiotis K, Démonet JF, Garibotto V, Giannakopoulos P, Gietl A, Hansson O, Herholz K, Jack CR Jr, Nobili F, Nordberg A, Snyder HM, Ten Kate M, Varrone A, Albanese E, Becker S, Bossuyt P, Carrillo MC, Cerami C, Dubois B, Gallo V, Giacobini E, Gold G, Hurst S, Lönneborg A, Lovblad KO, Mattsson N, Molinuevo JL.
Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
The Lancet NeurologyAbstractThe diagnosis of Alzheimer's disease can be improved by the use of biological measures. Biomarkers of functional impairment, neuronal loss, and protein deposition that can be assessed by neuroimaging...
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Tort-Merino A, Valech N, Peñaloza C, Grönholm-Nyman P, León M, Olives J, Estanga A, Ecay-Torres M, Fortea J, Martínez-Lage P, Molinuevo JL, Laine M, Rodríguez-Fornells A, Rami L
Early Detection of Learning Difficulties when Confronted with Novel Information in Preclinical Alzheimer's Disease Stage 1
Journal of Alzheimer's DiseaseAbstractWe employed a highly demanding experimental associative learning test (the AFE-T) to explore memory functioning in Preclinical Alzheimer's Disease stage 1 (PreAD-1) and stage 2 (PreAD-2). The task... -
Engelborghs S, Niemantsverdriet E, Molinuevo JL, Wallin A, Winblad B, Zetterberg H, Duits F, Teunissen CE
Consensus guidelines for lumbar puncture in patients with neurological diseases
Alzheimer's Dementia: Diagnosis, Assessment & Disease MonitoringAbstractIntroduction: Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others...
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Simonsen AH, Herukka SK, Andreasen N, Baldeiras I, Bjerke M, Blennow K, Engelborghs S, Frisoni GB, Gabryelewicz T, Galluzzi S, Handels R, Kramberger MG, Kulczyńska A, Molinuevo JL, Mroczko B, Nordberg A, Oliveira CR, Otto M, Rinne JO, Rot U, Saka E, Soininen H, Struyfs H, Suardi S, Visser PJ, Winblad B, Zetterberg H, Waldemar G.
Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia
Alzheimer's & DementiaAbstractThis article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-β1-42...
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Molinuevo JL, Rabin LA, Amariglio R, Buckley R, Dubois B, Ellis KA, Ewers M, Hampel H, Kloppel S, Rami L, Reisberg B, Saykin AJ, Sikkes S, Smart CM, Snitz BE, Sperling R, van der Flier WM, Wagner M, Jessen F, Subjective Cognitive Decline Initiative Working G
Implementation of subjective cognitive decline criteria in research studies
Alzheimer's & DementiaAbstractIntroduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group... -
Brugulat-Serrat A, Rojas S, Bargalló N, Conesa G, Minguillón C, Fauria K, Gramunt, Molinuevo JL, Gispert JD
Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project
BMJ OpenAbstractObjectives: To describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer's disease (AD). Design: Cross...
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Córdova-Palomera A, de Reus MA, Fatjó-Vilas M, Falcón C, Bargalló N, van den Heuvel MP, Fañanás L.
FKBP5 modulates the hippocampal connectivity deficits in depression: a study in twins
Brain Imaging and BehaviorAbstractThe hippocampus is a key modulator of stress responses underlying depressive behavior. While FKBP5 has been found associated with a large number of stress-related outcomes and hippocampal features...
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Ghaziri J, Tucholka A, Girard G, Houde JC, Boucher O, Gilbert G, Descoteaux M, Lippé S, Rainville P, Nguyen DK.
The Corticocortical Structural Connectivity of the Human Insula
Cerebral CortexAbstractThe insula is a complex structure involved in a wide range of functions. Tracing studies on nonhuman primates reveal a wide array of cortical connections in the frontal (orbitofrontal and prefrontal...
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Van Waalwijk van Doorn LJ, Gispert JD, Kuiperij HB AK, Yener G, Molinuevo JL, Verbeek MM
Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
Journal of Alzheimer's DiseaseAbstractCerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., Aβ42, total tau (t-tau), and...
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Gispert JD, Suárez-Calvet M, Monté GC, Tucholka A, Falcon C, Rojas S, Rami L, Sanchez-Valle, R, Llado A, Kleinberger G, Haass C, Molinuevo JL
Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
Alzheimer's & DementiaAbstractIntroduction: TREM2 is involved in the regulation of inflammatory response and phagocytosis. A soluble fragment (sTREM2) is often found abnormally increased in cerebrospinal fluid (CSF) in Alzheimer's...
