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Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.

  • Bonet N, Mascaro JM Jr, Hurtado-Navarro L, Angosto-Bazarra D, Callejas-Rubio JL, Clemente D, Souto A, Lima O, Palmou-Fontana N, Baselga E, Jiménez-Treviño S, Remesal A, Andreu-Barasoain M, Fernandez-Dominguez L, Riera-Monroig J, Aparicio M, Garcia-Herrero J, Pesqué D, Sanchez-Calvin MT, Lezana-Rosales JM, Correyero-Plaza M, Garcia-Villalba J, Bolaño V, Peiro S, Diaz M, Vlagea A, Lorca D, Fabregat V, Anton MC, Plaza S, Gonzalez-Granado LI, Postigo C, de Morales JMG, de la Fuente EG, Iglesias E, Gomez-Roman J, Vázquez-Triñanes C, Lopez-Robledillo JC, Ortego-Centeno N, Giménez-Arnau AM, Campistol JM, Laayouni H, de Landazuri IO, Yagüe J, Gonzalez-Roca E, Mensa-Vilaro A, Fornas O, Ramos E, Pelegrin P, Casals F, Arostegui JI

    Novel Insights into the Clinical Features, Genetic Spectrum and Clonal Evolution of Patients Carrying NLRP3 Mosaicism

    Journal of clinical immunology
    Abstract

    NLRP3 mosaicism is a well-established mechanism causing the monogenic autoinflammatory disease named cryopyrin-associated periodic syndromes (CAPS). The number of reported patients with NLRP3...

  • Lázaro I, Brugulat-Serrat A, Suárez-Calvet M, Fauria K, Minguillon C, Gispert JD, Molinuevo JL, Harris WS, Sánchez-Benavides G, Grau-Rivera O, Sala-Vila A

    Red blood cell omega-3 status and longitudinal cognition in individuals at risk of Alzheimer's disease

    The Journal of Nutrition
    Abstract

    Background: Many observational studies on dietary omega-3 fatty acids (FAs) and cognition focused on docosahexaenoic acid (DHA), because its significant role in brain. There is growing interest in...

  • Santos-Pujol E, Noguera-Castells A, Casado-Pelaez M, García-Prieto CA, Vasallo C, Campillo-Marcos I, Quero-Dotor C, Crespo-García E, Bueno-Costa A, Setién F, Ferrer G, Davalos V, Mereu E, Pluvinet R, Arribas C, Torre C, Villavicencio F, Sumoy L, Granada I, Coles NS, Acha P, Solé F, Mallo M, Mata C, Peregrina S, Gabaldón T, Llirós M, Pujolassos M, Carreras-Torres R, Lluansí A, García-Gil LJ, Aldeguer X, Samino S, Torné P, Ribalta J, Guardiola M, Amigó N, Yanes O, Martínez P, Sánchez-Vázquez R, Blasco MA, Oviedo J, Lemos B, Rius-Bonet J, Torrubiano M, Massip-Salcedo M, Khidir KA, Cao TH, Quinn PA, Jones DJL, Macip S, Brigos-Barril E, Moldes M, Barteri F, Muntané G, Laayouni H, Navarro A, Esteller M.

    The multiomics blueprint of the individual with the most extreme lifespan

    Cell Reports Medicine
    Abstract

    Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have...

  • Luckett ES, Abakkouy Y, Lorenzini L, Collij LE, Garcia DV, Visser PJ, den Braber A, Ritchie C, Boada M, Genius P, Vilor-Tejedor N, Gispert JD, Vandenberghe R, Barkhof F, Cleynen I

    Harmonizing genotype array data to understand genetic risk for brain amyloid burden in the AMYPAD PNHS Consortium

    Alzheimer's & Dementia
    Abstract

    Introduction: We sought to harmonize genotype data from the predementia AMYPAD (Amyloid Imaging to Prevent Alzheimer's Disease) Consortium, compute polygenic risk scores (PRS), and determine their...

  • Ottoy J, Owsicki N, Bilgel M, Binette AP, Salvadó G, Kang MS, Cash DM, Ewers M, La Joie R, Wisse LEM, Goubran M, Betthauser T

    Recent advances in neuroimaging of Alzheimer's disease and related dementias

    Alzheimer's & Dementia
    Abstract

    This review covers recent advances (2023-2024) in neuroimaging research into the pathophysiology, progression, and treatment of Alzheimer's disease (AD) and related dementias (ADRD). Despite the rapid...

  • Pujol J, Martínez-Vilavella G, Gómez-Herrera L, Rivas I, Gómez-Roig MD, Llurba E, Blanco-Hinojo L, Cirach M, Persavento C, Querol X, Gascón M, Foraster M, Gispert JD, Falcón C, Deus J, Dadvand P, Sunyer J.

    Unraveling the impact of prenatal air pollution for neonatal brain maturation

    Environment International
    Abstract

    Early brain development is highly sensitive to environmental influences. While prenatal exposure to airborne particulate matter (PM2.5) has been broadly associated with harmful effects, PM2.5 also...

  • van der Laan CM, Ip HF, Schipper M, Hottenga JJ, St Pourcain B, Zayats T, Pool R, Krapohl EML, Brikell I, Soler Artigas M, Cabana-Domínguez J, Nolte IM, Bolhuis K, Palviainen T, Zafarmand H, Gordon S, Aliev F, Burt SA, Wang CA, Saunders G, Karhunen V, Adkins DE, Border R, Peterson RE, Prinz JA, Thiering E, Vilor-Tejedor N, Ahluwalia TS, Allegrini A, Rimfeld K, Chen Q, Lu Y, Martin J, Bosch R, Ramos-Quiroga JA, Neumann A, Ensink J, Grasby KL, Morosoli JJ, Tong X, Marrington S, Scott JG, Shabalin AA, Corley R, Evans LM, Sugden K, Alemany S, Sass L, Vinding R, Ehli EA, Hagenbeek FA, Derks EM, Larsson H, Snieder H, Cecil C, Whipp AM, Korhonen T, Vuoksimaa E, Rose RJ, Uitterlinden AG, Haavik J, Harris JR, Helgeland Ø, Johansson S, Knudsen GPS, Njolstad PR, Lu Q, Rodriguez A, Henders AK, Mamun A, Najman JM, Brown S, Hopfer C, Krauter K, Reynolds CA, Smolen A, Stallings M, Wadsworth S, Wall TL, Eaves L, Silberg JL, Miller A, Havdahl A, Llop S, Lopez-Espinosa MJ, Bønnelykke K, Sunyer J, Arseneault L, Standl M, Heinrich J, Boden J, Pearson J, Horwood J, Kennedy M, Poulton R, Maes HH, Hewitt J, Copeland WE, Middeldorp CM, Williams GM, Wray N, Järvelin MR, McGue M, Iacono W, Caspi A, Moffitt TE, Whitehouse AJO, Pennell CE, Klump KL, Jiang C, Dick DM, Reichborn-Kjennerud T, Martin NG, Medland SE, Vrijkotte T, Kaprio J, Tiemeier H, Davey Smith G, Hartman CA, Oldehinkel AJ, Casas M, Ribasés M, Lichtenstein P, Lundström S, Plomin R, Bartels M, Nivard MG, Boomsma DI, Llonga N.

    Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

    Nature Genetics
    Abstract

    We performed a genome-wide association meta-analysis (GWAMA) of 290,134 attention-deficit/hyperactivity disorder (ADHD) symptom measures of 70,953 unique individuals from multiple raters, ages and...

  • Hok-A-Hin YS, Vermunt L, Peeters CFW, van der Ende EL, de Boer SCM, Meeter LH, de Houwer J, Seelaar H, van Swieten JC, Hu WT, Lleó A, Alcolea D, Engelborghs S, Sieben A, Chen-Plotkin A, Irwin DJ, van der Flier WM, Pijnenburg YAL, Teunissen CE, Del Campo M.

    Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia

    Abstract

    Background: Diagnosis of Frontotemporal dementia (FTD) and its specific underlying neuropathologies (frontotemporal lobar degeneration; FTLD-Tau and FTLD-TDP) are challenging, and thus, fluid...

  • Rodríguez-Fernández B, González-Escalante A, Genius P, E Evans T, Ortiz-Romero P, Minguillón C, Kollmorgen G, Ashton NJ, Zetterberg H, Blennow K, Gispert JD, Navarro A, Suárez-Calvet M, Sala-Vila A, Crous-Bou M, Vilor-Tejedor N.

    Longitudinal association of shorter leukocyte telomere length with CSF biomarker dynamics across early Alzheimer's disease stages in at-risk individuals

    EBioMedicine
    Abstract

    Background: Short telomere length (TL), a hallmark of biological ageing, has been associated with an increased risk of Alzheimer's disease (AD), but its pathophysiological role remains unclear. This...