News:Research and scientific results

The study identifies protein signatures specific to Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and integrates them into a single quantitative biomarker panel.

The results offer a new evolutionary perspective on human health and help explain why many genetic variants associated with common diseases have been maintained throughout evolution

The study provides preliminary evidence that the number of births may only influence cognitive decline in women who already have high levels of β-amyloid protein in their brain

The study shows that certain blood biomarkers can help rule out the presence of Alzheimer’s disease pathology in people with subjective memory complaints, although lumbar puncture remains necessary to confirm the diagnosis.

Fluid biomarkers remain highly valuable but are not yet sensitive enough to detect the earliest tau changes.

An international study involving data from the ALFA+ cohort shows that the combination of physical and social environmental exposures is a major driver of accelerated or delayed brain aging.

A study by the BBRC shows that the genetic risk of Alzheimer’s disease may manifest itself differently in women and men, paving the way for more personalised prevention strategies.

The study strengthens the validity of blood-based biomarkers for detecting Alzheimer’s disease and other dementias in diverse population settings, representing a key step towards more accessible and equitable diagnosis

This research describes new mechanisms linking the locus coeruleus to deep sleep and reveals differences according to sex and cerebral vascular status.