Artículos sobre Alzheimer
Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.
-
Sciancalepore F, Salemme S, Valletta M, Blasi MT, Remoli G, Zamboni G, Vanacore N, Canevelli M
Frailty and the brain: A narrative review of functional and pathological correlates
Ageing Research ReviewsAbstractFrailty influences the risk, phenotypic expression, and course of highly prevalent neurological conditions. However, the structural, functional, and pathological changes in the brain associated with...
-
Toccaceli Blasi M, Borioni MS, Nuti F, Belvisi D, Canevelli M, Fabbrini G, Bruno G
Presenilin-1 C779T Mutation Presenting With Rapidly Progressive Dementia and Medial Temporal Lobe MRI Changes
Case reports in neurological medicineAbstractIntroduction: Autosomal dominant Alzheimer's disease (ADAD), especially due to presenilin-1 (PSEN-1) gene mutations, may display a broad spectrum of clinical manifestations and neuroradiological...
-
López-Martos D, Suárez-Calvet M, Milà-Alomà M, Gispert JD, Salvadó G, Brugulat-Serrat A, Shekari M, Minguillon C, Zetterberg H, Blennow K, Grau-Rivera O, Sánchez-Benavides G; ALFA study.
Longitudinal Associations of Multimodal Core 1 Alzheimer Disease Biomarkers With Cognition in Aging and Preclinical Alzheimer Disease
NeurologyAbstractBackground and objectives: Addressing the association between early-changing Alzheimer disease (AD) biomarkers and cognition is essential for characterizing preclinical AD. However, few studies have...
-
Vilor-Tejedor N, Rodrigo A, Genius P, Rodríguez-Fernández B, Anastasi F, Pelkmans W, Navarro A, Adams HH, Wisse L, Gispert JD, Evans TE; ADNI.
Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment
Neuroimage: ClinicalAbstractThe hippocampus, crucial in cognitive aging and Alzheimer's disease (AD), shows early atrophy during disease progression. This study investigated 5-year trajectories of hippocampal volumes across AD...
-
Olvera-Rojas M, Solis-Urra P, Fernandez-Gamez B, Coca-Pulido A, Triviño-Ibáñez EM, Zeng X, Oberlin LE, Gispert JD, Erickson KI, Gómez-Río M, Karikari TK, Ortega FB, Esteban-Cornejo I.
Classification accuracies of plasma ptau217 vs. ptau217/Aβ1-42 for brain Aβ pathology in cognitively normal older adults
GeroscienceAbstractAlzheimer´s Disease (AD) and neurodegenerative blood-based biomarkers (BBMs) are transitioning from research settings to clinical practice, where accurate interpretation is critical for their...
-
Perneczky R, Quevenco FC, Hendrix J, Epelbaum S, Teunissen C, van der Flier WM, Suárez-Calvet M, Shi J, Mielke MM, Iwatsubo T, Palmqvist S, Hansson O
How can Alzheimer's disease blood-based biomarkers reach clinical practice?
Alzheimer's & DementiaAbstractIntroduction: Alzheimer's disease (AD) diagnosis has been based largely on clinical symptoms, despite their limited sensitivity and specificity. Biomarker use was proposed to support a more accurate...
-
Milà-Alomà M, Van Hulle C, Brugulat-Serrat A, Casals Brodú M, González-Escalante A, Sánchez-Benavides G, Shekari M, Castro-Aldrete L, Minguillón C, Novakova Martinkova J, Tartaglia MC, Quijano-Rubio C, Kollmorgen G, Schumacher Dimech A, Cirillo D, Quevenco FC, Iulita MF, Fauria K, Gispert JD, Ferretti MT, Santuccione Chadha A, Johnson SC, Suárez-Calvet M; ALFA study.
Sex differences in Alzheimer's disease CSF biomarkers and their association with Aβ pathology on PET in cognitively unimpaired individuals
Alzheimer's Research & TherapyAbstractBackground: Alzheimer's disease (AD) exhibits sex differences in prevalence, symptoms and risk factors. Understanding the effect of sex in AD cerebrospinal fluid (CSF) biomarkers and their association...
-
Anastasi F, Genius P, Rodriguez-Fernandez B, Yang C, Gorijala P, Timsina J, Hernández-Villamizar F, Lorenzini L, Del Campo M, Sánchez-Benavides G, Minguillon C, Navarro A, Cruchaga C, Suárez-Calvet M, Vilor-Tejedor N.
Proteomic polygenic risk scores of age-related plasma protein levels reveal a role for Metalloproteinase inhibitor 2 (TIMP2) in cognitive performance
Neurobiology of AgingAbstractSeveral studies in mice have identified blood proteins that influence brain aging, yet translating these findings into humans remains challenging. To address this gap, we conducted a systematic review...
-
Lorenzini L, Tranfa M, Pieperhoff L, Masserini F, Ten Kate M, Collij LE, Pontillo G, Luckett ES, Wink AM, Mutsaerts HJ, Oliveira TG, Altomare D, Boada M, den Braber A, Birck C, Buckley C, Farrar G, van der Flier W, Frisoni GB, Gismondi R, Gispert JD, Hanseeuw BJ, Jessen F, Marquié M, Mett A, Ritchie C, Salvadó G, Schöll M, Shekari M, Stephens AW, Tijms BM, Vállez García D, Vandenberghe R, Visser PJ, Roccatagliata L, Oxtoby NP, Pardini M, Barkhof F.
Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning
Alzheimer's & DementiaAbstractIntroduction: The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear.
Methods: We analyzed data from 1323 individuals without a diagnosis of...
-
Lara-Simon E, Gispert JD, Garcia-Ojalvo J, Villoslada P.
Multiscale networks in Alzheimer's disease identify brain hypometabolism as central across biological scales
PLoS Computational BiologyAbstractAlzheimer's disease encompasses multiple biological scales, spanning molecular factors, cells, tissues, and behavioral manifestations. The interplay among these scales in shaping the clinical...
