Publicaciones
Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.
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Lorenzini L, Ingala S, Wink AM, Kuijer JPA, Wottschel V, Dijsselhof M, Sudre CH, Haller S, Molinuevo JL, Gispert JD, Cash DM, Thomas DL, Vos SB, Prados F, Petr J, Wolz R, Palombit A, Schwarz AJ, Chételat G, Payoux P, Di Perri C, Wardlaw JM, Frisoni GB, Foley C, Fox NC, Ritchie C, Pernet C, Waldman A, Barkhof F, Mutsaerts HJMM; EPAD consortium
The Open-Access European Prevention of Alzheimer's Dementia (EPAD) MRI dataset and processing workflow
Neuroimage: ClinicalAbstractThe European Prevention of Alzheimer Dementia (EPAD) is a multi-center study that aims to characterize the preclinical and prodromal stages of Alzheimer's Disease. The EPAD imaging dataset includes...
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Simrén J, Andreasson U, Gobom J, Suarez Calvet M, Borroni B, Gillberg C, Nyberg L, Ghidoni R, Fernell E, Johnson M, Depypere H, Hansson C, Jonsdottir IH, Zetterberg H, Blennow K
Establishment of reference values for plasma neurofilament light based on healthy individuals aged 5-90 years
Brain Commun.AbstractThe recent development of assays that accurately quantify neurofilament light, a neuronal cytoskeleton protein, in plasma has generated a vast literature supporting that it is a sensitive, dynamic...
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Karikari TK, Ashton NJ, Brinkmalm G, Brum WS, Benedet AL, Montoliu-Gaya L, Lantero-Rodriguez J, Pascoal TA, Suárez-Calvet M, Rosa-Neto P, Blennow K, Zetterberg H
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility
Nat Rev NeurolAbstractWell-authenticated biomarkers can provide critical insights into the biological basis of Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and support therapeutic...
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Lorenzini L, Ansems LT, Lopes Alves I, Ingala S, Vállez García D, Tomassen J, Sudre C, Salvadó G, Shekari M, Operto G, Brugulat-Serrat A, Sánchez-Benavides G, Ten Kate M, Tijms B, Wink AM, Mutsaerts HJMM, den Braber A, Visser PJ, van Berckel BNM, Gispert JD, Barkhof F, Collij LE
Regional associations of white matter hyperintensities and early cortical amyloid pathology
Brain Commun.AbstractWhite matter hyperintensities (WMHs) have a heterogeneous aetiology, associated with both vascular risk factors and amyloidosis due to Alzheimer's disease. While spatial distribution of both amyloid...
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Ali M, Sung YJ, Wang F, Fernández MV, Morris JC, Fagan AM, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleó A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Haass C, Ewers M, Levin J, Farlow MR, Perrin RJ
Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk
PloS OneAbstractTwo genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience...
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Karikari TK, Ashton NJ, Brinkmalm G, Brum WS, Benedet AL, Montoliu-Gaya L, Lantero-Rodriguez J, Pascoal TA, Suárez-Calvet M, Rosa-Neto P, Blennow K, Zetterberg H
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility
Nat Rev NeurolAbstractWell-authenticated biomarkers can provide critical insights into the biological basis of Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and support therapeutic...
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Heeman F, Yaqub M, Hendriks J, van Berckel BNM, Collij LE, Gray KR, Manber R, Wolz R, Garibotto V, Wimberley C, Ritchie C, Barkhof F, Gispert JD, Vállez García D, Lopes Alves I, Lammertsma AA
Impact of cerebral blood flow and amyloid load on SUVR bias
EJNMMI ResearchAbstractBackground: Despite its widespread use, the semi-quantitative standardized uptake value ratio (SUVR) may be biased compared with the distribution volume ratio (DVR). This bias may be partially...
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Heeman F, Yaqub M, Hendriks J, van Berckel BNM, Collij LE, Gray KR, Manber R, Wolz R, Garibotto V, Wimberley C, Ritchie C, Barkhof F, Gispert JD, Vállez García D, Lopes Alves I, Lammertsma AA
Impact of cerebral blood flow and amyloid load on SUVR bias
EJNMMI ResearchAbstractBackground: Despite its widespread use, the semi-quantitative standardized uptake value ratio (SUVR) may be biased compared with the distribution volume ratio (DVR). This bias may be partially...
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Palmer WH, Telford M, Navarro A, Santpere G, Norman PJ
Human herpesvirus diversity is altered in HLA class I binding peptides
Proc Natl Acad Sci USAAbstractHerpesviruses are ubiquitous, genetically diverse DNA viruses, with long-term presence in humans associated with infrequent but significant pathology. Human leukocyte antigen (HLA) class I presents...
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Brugulat-Serrat A, Chen Y, Demnitz N, Ashour A, Adrion E, Ilinca S, Kinchin I, Almirall-Sanchez A, Öz D, Karanja W, Pintado M, Rogers N, Browning A, Petkuté I, Lawlor B
Roadmap for change in sex and gender inequities in brain health: A global perspective
Int J Geriatr PsychiatryAbstractNo abstract available.
