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Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.

  • Suemoto CK, Custodio N, Aguilar D, Avila-Funes JA, Baez S, Bagnati PM, Barnes LL, Brucki SMD, Calandri IL, Caramelli P, Cornejo-Olivas M, Derio CD, Ferreira ST, García AM, Grinberg LT, Ibanez AM, Isasi R, Josephy-Hernández SE, Porras ML, Llibre-Guerra JJ, Llibre-Rodriguez JJ, Lourenco MV, Meza BMM, Migeot J, Miranda JJ, Miranda-Castillo C, Mummery CJ, Parodi JF, Castro NP, Contreras RMS, Santamaría-García H, Slachevsky A, Souza-Talarico JN, Surace EI, Takada LT, Tsoy E, Pilalumbo MU, Zimmer ER, Fontana IC, Mahinrad S, Snyder HM, Carrillo MC.

    The landscape of dementia research, diagnosis, treatment, and care in Latin America

    Alzheimer's & Dementia
    Abstract

    Latin America is undergoing rapid population aging alongside a rising burden of dementia. While the region holds substantial potential for dementia risk reduction, challenges remain, such as delayed...

  • Daly T, López-Barrenechea I, Vergara P, Arshad F, Paplikar A, Ray Chaudhuri A, Crivelli L, Ibáñez A, Alladi S, Slachevsky A.

    Scientific knowledge about dementia: From the Global South to the world

    Alzheimer's & Dementia
    Abstract

    Most people with dementia live in low- and middle-income countries (LMICs), but scientific knowledge about dementia is dominated by Global North perspectives. This interdisciplinary article combines...

  • Timsina J, Jiang C, McCartney DL, Tao F, Dalmasso MC, Najar J, Anastasi F, Ohlei O, Puerta Fuentes R, Yang C, Bradley J, Western D, Ali M, Wang C, Yang C, Wu Y, Liu M, Budde J, Williams J, Mahoney R, Castillo Morales A, Hohman TJ, Dumitrescu L, Wang TC, Tesi N, Kern S, Waern M, Skoog I, van Harten A, Pijnenburg YAL, van der Flier WM, Sánchez-Juan P, Rodriguez-Rodriguez E, Kleineidam L, Peters O, Schneider A, Küçükali F, Bellenguez C, Grenier-Boley B, Heikkinen S, de Rojas I, Rujescu D, Scherbaum N, Hausner L, Düzel E, Grimmer T, Wiltfang J, Vandenberghe R, Engelborghs S, Heilmann-Heimbach S, Schmid M, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, Pérez-Tur J, Bullido MJ, Sánchez-Valle R, Álvarez V, García-González P, Mir P, Real LM, Piñol-Ripoll G, García-Alberca JM, Seelaar H, Ramakers I, Papma J, Hulsman M, Laske C, Teipel S, Priller J, Perneczky R, Buerger K, Nöthen MM, Lewczuk P, Kornhuber J, Hampel H, Giegling I, Goldhardt O, Diehl-Schmid J, Andrade V, Heneka MM, Frölich L, Vogelgsang J, Graff C, Thonberg H, Ullgren A, Papenberg G, Deleuze JF, Dufouil C, Wagner M, Jessen F, Holstege H, van Duijn C, Lebouvier T, Hannon O, Leinonen V, Soininen H, Herukka SK, Giedraitis V, Löwenmark M, Kilander L, Genius P, Rodríguez B, Luckett ES, Navarro A, Cano A, Marquié M, Blennow K, Zetterberg H, Lleo A, Boada M, Ruiz A, Lee VM, Van Deerlin VM, Deming Y, Johnson SC, Engelman CD, Pastor P, Alvarez I, Peskind ER, Heslegrave AJ, Saykin AJ, Nho K, Schindler SE, Morris JC, Holtzman DM, McDade E, Renton AE, Goate A, Ibanez L, Riemenschneider M, Albert MS, Laws SM, Porter T, O'Brien EK, Shaw LM, Tijms BM, Ingelsson M, Visser PJ, Hiltunen M, Sleegers K, Ritchie CW, Sims R, Belloy M, Lambert JC, Vilor-Tejedor N, Fernández MV, Li QS, Nagle MW, Marioni RE, Ramirez A, Bertram L, van der Lee SJ, Cruchaga C. 

    GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy

    Nature Communications
    Abstract

    Cerebrospinal fluid amyloid beta 42, total tau, and phosphorylated tau 181 are well accepted markers of Alzheimer's disease. These biomarkers better reflect disease pathogenesis compared to clinical...

  • Ibanez A, Roth N, Colverson A, Bailey C, Miller B, Durón-Reyes DE, Johnson N, Castaner O, Sacco PL, Cotter E, Melloni L.

    Music as a scientific metaphor for mind and brain

    Neuroscience and behavioural reviews
    Abstract

    Metaphors have long played multiple roles in conceptualizing the mind and brain, guiding the development and refinement of theoretical models and empirical questions. Early analogies (comparing the...

  • Scher, M.S., Eyre, H.A., Adalat, S., Hartikainen, K., Berk, M., Ibanez, A. & Markvarde, A. 

    Childhood health through matrescence empowers women to sustain life-course brain health

    npj Women's Health
    Abstract

    The spectrum from normal brain functions to neurological and mental health disorders represents the life-course neural exposome. Proactive interventions strengthen rescue and reparative choices...

  • Kassinopoulos M, Montesinos P, Falcon C, Huguet J, Minguillon C, Fauria K, Kollmorgen G, Quijano-Rubio C, Molinuevo JL, Grau-Rivera O, Zetterberg H, Blennow K, Suárez-Calvet M, Sanchez-Gonzalez J, Gispert JD; ALFA study

    Intracellular fluid accumulation underlies brain volume increases in early Alzheimer's disease

    Brain Communications
    Abstract

    In the preclinical stages of Alzheimer's disease, increased brain volume has been associated with amyloid-beta pathology, particularly in regions that undergo volume reductions as the disease...

  • Canevelli M, Pomati S, Salati E, Maestri G, Sarti G, Calia C, Pecorari C, Marchetti S, Cova I, Nielsen TR, Jørgensen K, Kjaergaard D, Sciancalepore F, Nuti F, Toccaceli Blasi M, Pantoni L, Vanacore N, Bruno G.

    Validation of the brief assessment of impaired cognition (BASIC) and brief assessment of impaired cognition questionnaire (BASIC-Q) in Italy

    Neurological Sciences
    Abstract

    Background: Brief and accurate tools are needed to enhance the prompt identification of cognitive disorders. This study aimed to translate and adapt two recently developed, highly accurate instruments...

  • Blujdea ER, van Bokhoven P, Martino-Adami PV, Marshe VS, Vromen EM, Hok-A-Hin YS, Boiten WA, Irwin DJ, Chen-Plotkin AS, Lemstra AW, Pijnenburg Y, van der Flier WM, Peters O, Hellmann-Regen J, Priller J, Schneider A, Wiltfang J, Jessen F, Düzel E, Buerger K, Perneczky R, Teipel S, Laske C, Brosseron F; DELCODE Consortium; Del Campo M, Wijdeven R, Visser PJ, Tijms BM, De Jager PL, Ramirez A, Teunissen CE, Vermunt L.

    Microglia protein profiles in CSF across Alzheimer's disease clinical stages

    Nature Aging
    Abstract

    Microglia are implicated in the progression of Alzheimer's disease (AD) pathology from its earliest stages, suggesting that cerebrospinal fluid (CSF) microglia profiling across clinical AD stages can...

  • Orellana P, Caviedes A, Gonzalez L, Ochoa-Rosales C, Carmona D, González-Silva C, Hernández H, Britton GB, Villarreal AE, Campos V, Hendrie H, Acosta-Uribe J, Pina-Escudero SD, Yokoyama JS, Vilor-Tejedor N, Parra M, Santamaria-García H, Ibañez A, de la Cruz R, Duran-Aniotz C

    Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta-analysis

    Alzheimer's & Dementia
    Abstract

    The apolipoprotein E (APOE) ε4 allele represents the strongest genetic risk factor for Alzheimer's disease (AD), but its role in genetically diverse Latin American and Caribbean (LAC) populations is...

  • Brugulat-Serrat A, Tsoy E, Sánchez-Benavides G, Milà-Alomà M, Gaynor LS, Grau-Rivera O, Gispert JD, Kramer JH, Possin KL

    European Prevention of Alzheimer's Disease (EPAD) Consortium. Detecting early memory changes in preclinical Alzheimer's disease using TabCAT favorites test: Data from the European Prevention of Alzheimer's Disease (EPAD) cohort

    Alzheimer's & Dementia
    Abstract

    Introduction: Sensitive memory paradigms may allow the detection of subtle memory changes associated with early Alzheimer's pathology in individuals without established clinical symptomatology.

    Methods...