Artículos sobre Alzheimer
Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.
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Falgàs N, Tort-Colet N, Martín-Sobrino I, Mayà G, Peña-González M, Rudilosso S, Gaig C, Bosch B, Arqueros A, Pérez-Millan A, Tort-Merino A, Fernández-Villullas G, Piñol-Ripoll G, Balasa M, Lladó A, Ruiz MM, Muñoz-Moreno E, Grau-Rivera O, Iranzo A, Grinberg LT, Sánchez-Valle R.
Relationship between locus coeruleus and slow-wave sleep in aging and Alzheimer's disease
Alzheimer's & DementiaAbstractIntroduction: Sleep disruption, particularly loss of slow-wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus...
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Genius P, Fernández-Bonet A, Rodríguez-Fernández B, Gallay C, Gonzalez-Escalante A, Sánchez-Benavides G, López-Martos D, Esteller M, Navarro A, Gispert JD, Brugulat-Serrat A, Vilor-Tejedor N
Sex-specific early cognitive changes are linked to global and pathway-specific genetic risk for Alzheimer's disease in at-risk individuals
Biology of sex differencesAbstractAlzheimer's disease (AD) is a progressive neurodegenerative condition in which genetic predisposition plays a key role, yet the sex-specific mechanisms linking genetic risk to early cognitive changes...
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Bolsewig K, Bellomo G, Hok-A-Hin YS, Al Idrissi I, Vermunt L, Lleó A, Alcolea D, Sieben A, Engelborghs S, Simonsen AH, Hasselbalch SG, Bech S, Morrema THJ, Hoozemans JJM, Bol JGJM, van Alphen J, Gaetani L, Chiasserini D, Paolini Paoletti F, Parnetti L, Kang S, Lee YG, Jeon S, Lee A, Jeon S, Ye BS, Del Campo Milán M, van der Flier WM, van de Berg WDJ, Lemstra AW, Willemse EAJ, Teunissen CE
A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders
Nature MedicineAbstractAccurate diagnosis of dementia with Lewy bodies (DLB) remains challenging, with misdiagnosis potentially leading to harmful treatment decisions. DOPA decarboxylase (DDC) shows promise as a...
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Orellana P, Henríquez F, Cabral-Miranda F, Hernandez H, Ferreira PCL, Bellaver B, Caviedes A, Pizarro M, Gonzalez-Silva C, Marin-Diaz N, Riquelme P, Pozo N, Damm F, Court FA, Gonzalez-Billault C, Lillo P, Thumala-Dockendorff D, Cerda M, Villagra R, de la Cruz R, K Karikari T, Ibañez A, Zetterberg H, A Pascoal T, Duran-Aniotz C, Slachevsky A.
Plasma ATN biomarkers across the alzheimer's disease continuum in a Chilean community- and clinic-based cohort
Alzheimer's Research & TherapyAbstractBackground: Plasma biomarkers have emerged as robust indicators of Alzheimer's disease (AD) pathology, offering accessible tools for staging and stratification. However, their expression across...
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Caviedes A, Cabral-Miranda F, Orellana P, Hernández H, Henríquez F, Gonzalez-Gomez R, Pizarro M, Migeot J, Ochoa-Rosales C, Gonzalez-Silva C, Marin-Diaz N, Coronel-Oliveros C, Santamaría-García H, Carmona D, García AM, Slachevsky A, Singleton A, Qi AY, Lawlor B, Miller B, Dhooge C, Pantazis C, Udeh-Momoh CT, Aguillón D, Matallana DL, Zimmer ER, Resende EPF, Farina FR, Cabello F, Lopera F, Zetterberg H, Avila-Funes JA, Acosta-Uribe J, Possin KL, Kosik KS, Hu K, Takada LT, de Oliveira MO, Maito MA, Suárez-Calvet M, Godoy ME, Behrens MI, Parra MA, Del Campo M, Bruno M, Gelvez N, Pozo-Castro N, Cochran JN, Custodio N, Ortega R, Santibanez R, de la Cruz R, Montesinos R, McDonagh S, Bandres-Ciga S, Javandel S, Brucki SMD, Pina-Escudero SD, Valcour V, Li Z, Yokoyama JS, Ibañez A, Duran-Aniotz C;
Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America
Nature AgingAbstractDementia diagnosis increasingly relies on blood-based biomarkers, yet their performance in diverse populations remains insufficiently characterized. Latin America, with substantial genetic and...
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Hok-A-Hin YS, Bongers B, Bolsewig K, Boonkamp L, Ruiters DN, Lemstra AW, van der Flier WM, Pijnenburg YAL, Del Campo M, Teunissen CE
Development and validation of a novel panel of CSF biomarkers for Alzheimer's disease
Alzheimer's Research & TherapyAbstractBackground: Using proximity extension proteomic arrays (PEA), we previously identified a nine-biomarker CSF protein panel reflecting different biological processes dysregulated in Alzheimer´s disease...
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Gonzalez-Gomez R, Demnitz N, Coronel C, Gates AT, Kjaer M, Siebner HR, Boraxbekk CJ, Ibanez AM
Randomized controlled trial of resistance exercise and brain aging clocks
GeroscienceAbstractExercise improves cognition, mental wellbeing, and protects against neurodegeneration. However, most prior neuroscience studies have focused on localized brain changes without quantifying their impact...
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Álvarez-Bustos A, Andres-Lacueva C, Ara I, Arévalo MA, Bolaños JP, Coto-Montes A, Enriquez JA, Escames G, García-García FJ, Gómez-Cabrera MC, Grau-Rivera O, Izquierdo M, Martínez Velilla N, Matheu A, Menéndez Colino R, Muñoz Torres M, Nogués X, Oliva J, Orts-Cortés MI, Párraga Martínez I, Priego F, Rabassa-Bonet M, Rol MÁ, Serra-Rexach JA, Tarazona-Santabalbina FJ, Rodríguez-Mañas L, Abizanda P
Consensus document on frailty: conceptualization, detection, multidisciplinary management and future roadmap
The Journal of NutritionAbstractBackground: The lack of a universally accepted definition, a gold-standard assessment tool, and sufficient evidence-based interventions has hindered the integration of frailty into routine clinical...
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Vilor-Tejedor N, Danso S, Albanus RD, Billingsley K, Evans TE, Lee LY, Wang S, Jiang J, Liu H, Ross J, Chilla G
Advancing global dementia research through equity and inclusion
Alzheimer's & DementiaAbstractDespite the global burden of dementia, research remains dominated by high-income, Western populations, limiting the generalizability and equity of findings. In this Perspective, we highlight the...
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Piromalli D, Cañadas-Romero MA, Ivirico-Prats M, Suárez-Calvet M, Beriain Bañares A, Sánchez-Valle M, Ortíz-Castelví L.
Areaalzheimer: development of a digital platform for caregivers based on the results of a needs analysis and mixed-methods pilot evaluation process
Frontiers in Digital HealthAbstractIntroduction: This study describes the user-centred design and evaluation of AreAreaAlzheimer, a web-based digital platform developed to support family caregivers of individuals with dementia...
