Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Pieperhoff L, Lorenzini L, Mastenbroek S, Tranfa M, Shekari M, Wink AM, Wolz R, Grootoonk S, Ritchie C, Boada M, Marquié M, van der Flier W, Vandenberghe R, Hanseeuw BJ, Martínez-Lage P, Payoux P, Visser PJ, Schöll M, Frisoni GB, Stephens A, Buckley C, Farrar G, Jessen F, Grau-Rivera O, Gispert JD, García DV, Mutsaerts H, Barkhof F, Collij LE
Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study
Neuroimage: ClinicalAbstractThe impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer's disease (AD), and its interaction with risk factors like sex and APOE-ε4 carriership, remains unclear. In...
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Tranfa M, Pieperhoff L, Pontillo G, Luckett ES, Collij LE, Oliveira TG, Tesi N, Vilor-Tejedor N, Altmann A, Roccatagliata L, Pardini M, Holstege H, Reinders M, Payoux P, Martinez-Lage P, Ritchie CW, Waldman A, Wardlaw JM, Gispert JD, Salvadó G, Brunetti A, Mutsaerts HJMM, Wink AM, Barkhof F, Lorenzini L
Polygenic pathways shape white matter vulnerability to Alzheimer's disease-related pathophysiological changes
Alzheimer's Research & TherapyAbstractBackground: The accumulation of amyloid-β1-42 (Aβ1-42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer's disease (AD) has led to a biological definition...
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Sciancalepore F, Salemme S, Valletta M, Blasi MT, Remoli G, Zamboni G, Vanacore N, Canevelli M
Frailty and the brain: A narrative review of functional and pathological correlates
Ageing Research ReviewsAbstractFrailty influences the risk, phenotypic expression, and course of highly prevalent neurological conditions. However, the structural, functional, and pathological changes in the brain associated with...
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Toccaceli Blasi M, Borioni MS, Nuti F, Belvisi D, Canevelli M, Fabbrini G, Bruno G
Presenilin-1 C779T Mutation Presenting With Rapidly Progressive Dementia and Medial Temporal Lobe MRI Changes
Case reports in neurological medicineAbstractIntroduction: Autosomal dominant Alzheimer's disease (ADAD), especially due to presenilin-1 (PSEN-1) gene mutations, may display a broad spectrum of clinical manifestations and neuroradiological...
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López-Martos D, Suárez-Calvet M, Milà-Alomà M, Gispert JD, Salvadó G, Brugulat-Serrat A, Shekari M, Minguillon C, Zetterberg H, Blennow K, Grau-Rivera O, Sánchez-Benavides G; ALFA study.
Longitudinal Associations of Multimodal Core 1 Alzheimer Disease Biomarkers With Cognition in Aging and Preclinical Alzheimer Disease
NeurologyAbstractBackground and objectives: Addressing the association between early-changing Alzheimer disease (AD) biomarkers and cognition is essential for characterizing preclinical AD. However, few studies have...
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Vilor-Tejedor N, Rodrigo A, Genius P, Rodríguez-Fernández B, Anastasi F, Pelkmans W, Navarro A, Adams HH, Wisse L, Gispert JD, Evans TE; ADNI.
Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment
Neuroimage: ClinicalAbstractThe hippocampus, crucial in cognitive aging and Alzheimer's disease (AD), shows early atrophy during disease progression. This study investigated 5-year trajectories of hippocampal volumes across AD...
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Olvera-Rojas M, Solis-Urra P, Fernandez-Gamez B, Coca-Pulido A, Triviño-Ibáñez EM, Zeng X, Oberlin LE, Gispert JD, Erickson KI, Gómez-Río M, Karikari TK, Ortega FB, Esteban-Cornejo I.
Classification accuracies of plasma ptau217 vs. ptau217/Aβ1-42 for brain Aβ pathology in cognitively normal older adults
GeroscienceAbstractAlzheimer´s Disease (AD) and neurodegenerative blood-based biomarkers (BBMs) are transitioning from research settings to clinical practice, where accurate interpretation is critical for their...
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Perneczky R, Quevenco FC, Hendrix J, Epelbaum S, Teunissen C, van der Flier WM, Suárez-Calvet M, Shi J, Mielke MM, Iwatsubo T, Palmqvist S, Hansson O
How can Alzheimer's disease blood-based biomarkers reach clinical practice?
Alzheimer's & DementiaAbstractIntroduction: Alzheimer's disease (AD) diagnosis has been based largely on clinical symptoms, despite their limited sensitivity and specificity. Biomarker use was proposed to support a more accurate...
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Milà-Alomà M, Van Hulle C, Brugulat-Serrat A, Casals Brodú M, González-Escalante A, Sánchez-Benavides G, Shekari M, Castro-Aldrete L, Minguillón C, Novakova Martinkova J, Tartaglia MC, Quijano-Rubio C, Kollmorgen G, Schumacher Dimech A, Cirillo D, Quevenco FC, Iulita MF, Fauria K, Gispert JD, Ferretti MT, Santuccione Chadha A, Johnson SC, Suárez-Calvet M; ALFA study.
Sex differences in Alzheimer's disease CSF biomarkers and their association with Aβ pathology on PET in cognitively unimpaired individuals
Alzheimer's Research & TherapyAbstractBackground: Alzheimer's disease (AD) exhibits sex differences in prevalence, symptoms and risk factors. Understanding the effect of sex in AD cerebrospinal fluid (CSF) biomarkers and their association...
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Anastasi F, Genius P, Rodriguez-Fernandez B, Yang C, Gorijala P, Timsina J, Hernández-Villamizar F, Lorenzini L, Del Campo M, Sánchez-Benavides G, Minguillon C, Navarro A, Cruchaga C, Suárez-Calvet M, Vilor-Tejedor N.
Proteomic polygenic risk scores of age-related plasma protein levels reveal a role for Metalloproteinase inhibitor 2 (TIMP2) in cognitive performance
Neurobiology of AgingAbstractSeveral studies in mice have identified blood proteins that influence brain aging, yet translating these findings into humans remains challenging. To address this gap, we conducted a systematic review...
