Publicacions
Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.
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Lorenzo T, Ngandu T, Lehtisalo J, Antikainen R, Gispert JD, Kemppainen N, Laatikainen T, Lindström J, Rinne J, Soininen H, Strandberg T, Torre R, Tuomilehto J, Solomon A, Kivipelto M.
Associations of Prediabetes, Diabetes and Glucose-Related Markers With Cognition and Neuroimaging in a 2-Year Multidomain Lifestyle Randomised Controlled Trial.
Diabetes/Metabolism research and reviewsAbstractAims: Few longitudinal studies have explored Oral Glucose Tolerance Test markers (OGTT) and both cognitive and brain changes. We investigated OGTT and other glycaemia and insulin resistance markers...
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Contador I, Akinci M, Palpatzis E, Aguilar-Domínguez P, Deulofeu C, Fuentes-Julian S, Fauria K, Minguillón C, Grau-Rivera O, Sánchez-Benavides G, Arenaza-Urquijo EM
Psychological resilience trajectories after the COVID-19 pandemic: the role of lifestyle and psychosocial factors in a cohort at increased alzheimer's disease risk
Social psychiatry and psychiatric epidemiologyAbstractPurpose: This longitudinal cohort study evaluates whether lifestyle and psychosocial factors are associated with psychological resilience at two time points of COVID-19 pandemic. Moreover, we...
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Stankeviciute L, Tort-Colet N, Fernández-Arcos A, Sánchez-Benavides G, Minguillón C, Fauria K, Holst SC, Garcés P, Mueggler T, Zetterberg H, Blennow K, Iranzo Á, Suárez-Calvet M, Gispert JD, Molinuevo JL, Grau-Rivera O
Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers
Alzheimer's & DementiaAbstractIntroduction: Sleep disturbances are prevalent in Alzheimer's disease (AD), probably emerging during its preclinical stage. Poor subjective sleep quality is linked to reduced brain volume and cortical...
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Doecke JD, Bellomo G, Vermunt L, Alcolea D, Halbgebauer S, In 't Veld S, Mattsson-Carlgren N, Veverova K, Fowler CJ, Boonkamp L, Houtkamp IM, Koel-Simmerlink M, Verberk IMW, Gaetani L, Toja A, Wojdała AL, Fortea J, Pijnenburg Y, Lemstra A, van der Flier W, Hort J, Otto M, Hansson O, Parnetti L, Masters CL, Lleó A, González-Escalante A, Contador J, Suárez-Calvet M, Fernández-Lebrero A, Puig-Pijoan A, Ortiz-Romero P, Jiménez-Moyano E, Minguillón C, Del Campo M, Teunissen C
Diagnostic performance of plasma Aβ42/40 ratio, p-tau181, GFAP, and NfL along the continuum of Alzheimer's disease and non-AD dementias: An international multi-center study
Alzheimer's & DementiaAbstractIntroduction: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aβ42/40) may have diagnostic and prognostic value...
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van Maurik IS, Altomare D, Collij LE, Caprioglio C, Moro C, Garibotto V, Demonet JF, Scheltens P, Farrer G, Gismondi R, Stephens AW, Gispert JD, Molinuevo JL, Grau-Rivera O, Edison P, Walker Z, Jessen F, Dzrezga A, Zeyen P, Payoux P, Saint-Aubert L, Delrieu J, Nordberg A, Barkhof F, Frisoni GB, Berkhof J
Costs and Cost-Utility of Amyloid-PET in the Diagnostic Process of Memory Clinic Patients
European Journal of NeurologyAbstractBackground: Amyloid positron emission tomography (PET) is instrumental in achieving an accurate diagnosis and may help to limit health-seeking behavior. Currently, amyloid-PET is not routinely used in...
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Gonzalez-Ortiz F, Vávra J, Payne E, Kirsebom BE, Sjöbom U, Santos C, Júlvez J, Kramer K, Zalcberg D, Montoliu-Gaya L, Turton M, Harrison P, Hellström A, Zetterberg H, Fladby T, Suárez-Calvet M, Sanders RD, Blennow K.
The potential dual role of tau phosphorylation: plasma phosphorylated-tau217 in newborns and Alzheimer's disease
Brain CommunicationsAbstractTau phosphorylation plays an important role in brain physiology and pathology. During foetal development, it supports microtubule dynamics and neuroplasticity, whereas in Alzheimer's disease (AD), it...
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González-Escalante A, Milà-Alomà M, Brum WS, Ashton NJ, Ortiz-Romero P, Shekari M, Campo MD, Anastasi F, Quijano-Rubio C, Kollmorgen G, Minguillón C, Sánchez-Benavides G, Grau-Rivera O, Gispert JD, Zetterberg H, Vilor-Tejedor N, Blennow K, Suárez-Calvet M.
A plasma biomarker panel for detecting early amyloid-β accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer's disease
EBioMedicineAbstractBackground: Plasma biomarkers of Alzheimer's disease (AD) change during preclinical stages, indicating potential for detecting amyloid-β (Aβ) pathology in cognitively unimpaired (CU) individuals...
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López-Martos D, Brugulat-Serrat A, Suárez-Calvet M, Milà-Alomà M, Minguillon C, Domingo Gispert J, Zetterberg H, Blennow K, Grau-Rivera O, Sánchez-Benavides G
Robust longitudinal neuropsychological norms in Spanish individuals with nonpathological Alzheimer's disease biomarkers
NeuropsychologyAbstractObjective: Neuropsychological norms serve to identify cognitive impairment and monitor neurodegenerative disease progression. However, longitudinal data are limited, and conventional approaches do not...
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Ashton NJ, Benedet AL, Molfetta GD, Pola I, Anastasi F, Fernández-Lebrero A, Puig-Pijoan A, Keshavan A, Schott J, Tan K, Simrén J, Gomes BF, Montoliu-Gaya L, Isaacson R, Bongianni M, Tolassi C, Cantoni V, Alberici A, Padovani A, Zanusso G, Pilotto A, Borroni B, Suárez-Calvet M, Blennow K, Zetterberg H.
Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay
Alzheimer's & DementiaAbstractIntroduction: Recent advancements in immunological methods accurately quantify biofluid biomarkers for Alzheimer's disease (AD) pathology. Despite progress, more biomarkers, ideally in blood, are...
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Laurell AAS, Mak E, Dounavi ME, Underwood BR, Dauvilliers Y, Dudas RB, Marguet O, Ritchie CW, Koychev I, Lawlor BA, Naci L, Malhotra P, Grau-Rivera O, Gispert JD, O'Brien JT
Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults. Alzheimers Dement
Alzheimer's & DementiaAbstractIntroduction: Sleep dysfunction in those at higher risk of dementia may be associated with early structural changes to the hypothalamus.
Methods: We used multivariate regression to analyze self...
