Artículos sobre Alzheimer
Artículos científicos publicados por los investigadores del Barcelonaβeta Brain Research Center (BBRC), relacionados con la enfermedad de Alzheimer, neuroimagen, memoria y enfermedades neurodegenerativas, entre otros campos.
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Molinuevo JL, Cami J, Carné X, Carrillo MC, Georges J, Isaac MB, Khachaturian Z, Kim SYH, Morris JC, Pasquier F, Ritchie C, Sperling R, Karlawish J.
Ethical challenges in preclinical Alzheimer's disease observational studies and trials: Results of the Barcelona summit
Alzheimer's & DementiaAbstractAlzheimer's disease (AD) is among the most significant health care burdens. Disappointing results from clinical trials in late-stage AD persons combined with hopeful results from trials in persons...
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Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, Brendel M, Rominger A, Alcolea D, Fortea J, Lleo A, Blesa R, Gispert JD, Sanchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, Haass C
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
EMBO Molecular MedicineAbstractTREM2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of TREM2 are associated with increased risk of Alzheimer's disease (AD). TREM2 is a type-1 protein...
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Van Eldik LJ, Carrillo MC, Cole PE, Feuerbach D, Greenberg BD, Hendrix JA, Kennedy M, Kozauer N, Margolin RA, Molinuevo JL, Mueller R, Ransohoff RM, Wilcock DM, Bain L, Bales K.
The roles of inflammation and immune mechanisms in Alzheimer's disease
Alzheimer's & Dementia: Translational Research & Clinical InterventionsAbstractThe Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune...
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Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA, Habert MO, Holtzman DM, Kivipelto M, Lista S, Molinuevo JL, Jack CR Jr, Iwg & Amer Alzheimer's Assoc P.
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria
Alzheimer's & DementiaAbstractDuring the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries...
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Gramunt N, Sánchez-Benavides G, Buschke H, Dieguez-Vide F, Pena-Casanova J, Masramon X, Fauria K, Gispert JD, Molinuevo JL
The Memory Binding Test: Development of Two Alternate Forms into Spanish and Catalan
Journal of Alzheimer's DiseaseAbstractBackground: The Memory Binding Test (MBT) is emerging as a promising tool for the detection of subtle memory impairment suggestive of Alzheimer's disease (AD). For such a test to be widely accessed...
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Vradenburg G, Doody R, Fontoura P, Molinuevo JL, Zetterberg H.
Building pace and scale in the fight against alzheimer's: the road to 2025 and beyond
Neurobiology of Aging -
Dion LA, Bouchard MF, Sauvé S, Barbeau B, Tucholka A, Major P, Gilbert G, Mergler D, Saint-Amour D.
MRI pallidal signal in children exposed to manganese in drinking water
NeurotoxicologyAbstractBackground: Manganese (Mn) can have neurotoxic effects upon overexposure. We previously reported poorer cognitive and motor development in children exposed to Mn through drinking water, suggesting...
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Gispert JD, Monté GC, Falcon C, Tucholka A, Rojas S, Sanchez-Valle R, Antonell A, Llado A, Rami L, Molinuevo JL.
CSF YKL-40 and pTau181 are related to different cerebral morphometric patterns in early AD
Neurobiology of AgingAbstractCerebrospinal fluid (CSF) concentrations of YKL-40 that serve as biomarker of neuroinflammation are known to be altered along the clinico-biological continuum of Alzheimer's disease (AD). The specific...
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Ritchie CW, Molinuevo JL, Truyen L, Satlin A, Van der Geyten S, Lovestone S, European Prevention of Alzheimer's Dementia (EPAD) Consortium.
Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project
The Lancet PsychiatryAbstractAlzheimer's dementia affects more than 40 million people worldwide with substantial increases in prevalence anticipated. Interventions that either modify risk or reduce the development of early...
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Duits FH, Martinez-Lage P, Paquet C, Engelborghs S, Lleo A, Hausner L, Molinuevo JL, Stomrud E, Farotti L, Ramakers IHGB, Tsolaki M, Skarsgard C, Astrand R, Wallin A, Scheltens P, Blennow K.
Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
Alzheimer's & DementiaAbstractIntroduction: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic...
