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News
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Publications
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET, Zafarmand MH, Vilor-Tejedor N , Wang CA, Jaddoe VWV et al.
A Trans-Ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated With Childhood Obesity
Hum Mol GenetAbstractAlthough hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with... -
Marizzoni M, Ferrari C, Babiloni C, Albani D, Barkhof F, Cavaliere L, Didic M, Forloni G, Fusco F, Galluzzi S, Hensch T, Jovicich J, Marra C, Molinuevo JL , Nobili F, Parnetti L, Payoux P, Ranjeva JP, Ribaldi F, Rolandi E, Rossini PM, Salvatore M, Soricelli A, Tsolaki M, Visser PJ, Wiltfang J, Richardson JC, Bordet R, Blin O, Frisoni GB
CSF Cutoffs for MCI Due to AD Depend on APOEε4 Carrier Status
Neurobiol AgingAbstractAmyloid and tau pathological accumulation should be considered for Alzheimer's disease (AD) definition and before subjects' enrollment in disease-modifying trials. Although age, APOEε4, and sex...
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López de Las Hazas MC, Gil-Zamorano J, Cofán M, Mantilla-Escalante DC, Garcia-Ruiz A, Del Pozo-Acebo L, Pastor O, Yañez-Mo M, Mazzeo C, Serra-Mir M, Doménech M, Valls-Pedret C, Rajaram S, Sabaté J, Ros E, Sala-Vila A, Dávalos A.
One-year dietary supplementation with walnuts modifies exosomal miRNA in elderly subjects
European Journal of NutritionAbstractPurpose: Epidemiological studies and clinical trials support the association of nut consumption with a lower risk of prevalent non-communicable diseases, particularly cardiovascular disease. However...
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Ahmadi A, De Toma I, Vilor-Tejedor N, Eftekhariyan Ghamsari MR, Sadeghi I.
Transposable elements in brain health and disease
Ageing Research ReviewsAbstractTransposable elements (TEs) occupy a large fraction of the human genome but only a small proportion of these elements are still active today. Recent works have suggested that TEs are expressed and...
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Ballard C, Aarsland D, Cummings J, O'Brien J, Mills R, Molinuevo JL, Fladby T, Williams G, Doherty P, Corbett A, Sultana J.
Drug repositioning and repurposing for Alzheimer disease
Nature Reviews NeurologyAbstractDrug repositioning and repurposing can enhance traditional drug development efforts and could accelerate the identification of new treatments for individuals with Alzheimer disease (AD) dementia and...
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Adrià Casamitjana, Paula Petrone, José Luis Molinuevo, Juan Domingo Gispert, Verónica Vilaplana
Projection to Latent Spaces disentangles pathological effects on brain morphology in the asymptomatic phase of Alzheimer’s disease
Frontiers in NeurologyAbstractAlzheimer's disease (AD) continuum is defined as a cascade of several neuropathological processes that can be measured using biomarkers, such as cerebrospinal fluid (CSF) levels of Aβ, p-tau, and t-ta...
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Carles Falcon, Oriol Grau-Rivera, Marc Suárez-Calvet, Beatriz Bosch, Raquel Sánchez-Valle,
Sex differences of longitudinal brain changes in cognitively unimpaired adults
Journal of Alzheimer's DiseaseAbstractBackground: There is increasing evidence that AD progression differs by sex.
Objective: The aim of this work was to determine sex differences in the association of baseline levels of cerebrospinal...
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Natalia Vilor-Tejedor, Grégory Operto, Tavia E Evans, Carles Falcon, Marta C
Effect of BDNF Val66Met Polymorphism on Hippocampal Subfield Volumes and Compensatory Interaction with APOE-ε4
Brain Structure and FunctionAbstractBackground: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous...
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Casamitjana A, Vilaplana V, Puch S, Aduriz A, López C, Operto G, Cacciaglia R, Falcón C, Molinuevo JL, Gispert JD
NeAT: A Nonlinear Analysis Toolbox for Neuroimaging
NeuroinformaticsAbstractNeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely... -
Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, Baker L, Belleville S, Brodaty H, Brucki SM, Calandri I, Caramelli P, Chen C, Chertkow H, Chew E, Choi SH, Chowdhary N, Crivelli L, Torre R, Du Y, Dua T, Espeland M, Feldman HH, Hartmanis M, Hartmann T, Heffernan M, Henry CJ, Hong CH, Håkansson K, Iwatsubo T, Jeong JH, Jimenez-Maggiora G, Koo EH, Launer LJ, Lehtisalo J, Lopera F, Martínez-Lage P, Martins R, Middleton L, Molinuevo JL,
World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia
Alzheimer's & DementiaAbstractReducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a...
