GLYMPH-AD

GLYMPH-AD will analyse how changes in blood pressure during sleep may affect the brain’s “cleaning” mechanisms and contribute to the risk of developing Alzheimer’s disease.

The study focuses on the study glymphatic system, a waste-clearance network that is particularly active during sleep. This system acts as a brain cleansing pathway that helps remove waste substances, including the beta-amyloid and tau proteins involved in Alzheimer’s disease. When this mechanism fails, these waste products can build up and promote the development of the disease.

For four years, the research will focus on cognitively unimpaired people but at increased risk of Alzheimer's disease, with particular attention to gender differences and changes related to menopause.

In the long term, the results of the project could help to design new preventive strategies, and sex-specific interventions, with the aim of delaying or preventing the onset of the disease.

Principal Investigator: Gonzalo Sánchez Benavides.

The GLYMPH-AD project (code PID2024-163071OB-I00) is funded by MICIU/AEI/10.13039/501100011033 and the European Union, FEDER.