Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Sánchez-Benavides G, Grau-Rivera O, Cacciaglia R, Suárez-Calvet M, Falcon C, Minguillón C, Gramunt N, Gispert JD, Molinuevo JL
Distinct Cognitive and Brain Morphological Features in Healthy Subjects Unaware of Informant-Reported Cognitive Decline
Journal of Alzheimer's DiseaseAbstractBackground: Subtle cognitive decline preceding cognitive impairment can be self-perceived, referred to as subjective cognitive decline (SCD), or go unrecognized. Objective: To study the clinical...
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Cacciaglia R, Molinuevo JL, Sánchez-Benavides G, Falcon C, Gramunt N, Brugulat-Serrat A, Grau-Rivera O, Gispert JD
Episodic Memory and Executive Function in cognitively Healthy Individuals Display Distinct Neuroanatomical Correlates which are Differentially Modulated by Aging
Human Brain MappingAbstractThe neuroanatomical bases of episodic memory (EM) and executive functions (EFs) have been widely addressed in patients with brain damage and in individuals with neurologic disorders. These studies...
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Cacciaglia R, Molinuevo JL, Falcón C, Brugulat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillon C, Fauria K, Gispert JD
Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease
Alzheimer's & DementiaAbstractIntroduction: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains...
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Casamitjana A, Petrone P, Tucholka A, Falcon C, Skouras S, Molinuevo JL, Vilaplana V, Gispert JD, for the Alzheimer's Disease Neuroimaging Initiative
MRI-Based Screening of Preclinical Alzheimer’s Disease for Prevention Clinical Trials
Journal of Alzheimer's DiseaseAbstractThe identification of healthy individuals harboring amyloid pathology represents one important challenge for secondary prevention clinical trials in Alzheimer's disease (AD). Consequently, noninvasive...
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Cacciaglia R, Molinuevo JL, Falcón C, Brugulat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillon C, Fauria K, Gispert JD
Impact of APOE genetic variant on brain morphology in a cohort of cognitively healthy middle-aged individuals with enriched genetic risk for Alzheimer’s disease
Alzheimer's DementiaAbstractIntroduction: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains...
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Operto G, Cacciaglia R, Grau O, Falcón C, Brugulat-Serrat A, Ródenas P, Ramos R, Morán S, Esteller M, Bargalló N, Molinuevo JL, Gispert JD
White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes
Alzheimer's Research & TherapyAbstractBackground: The ε4 allele of the apolipoprotein E gene (APOE-ε4) is the strongest genetic factor for late-onset Alzheimer's disease. During middle age, cognitively healthy APOE-ε4 carriers already...
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Rojas S, Brugulat-Serrat A, Bargalló N, Minguillón C, Tucholka A, Falcon C, Carvalho A, Morán S, Esteller M, Gramunt N, Fauria K, Camí J, Molinuevo JL, Gispert JD
Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45-75: Results from the ALFA study
Journal of Cerebral Blood Flow & MetabolismAbstractCerebral white matter hyperintensities are believed the consequence of small vessel disease and are associated with risk and progression of Alzheimer's disease. The ɛ4 allele of the APOE gene is the...
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Tucholka A, Grau-Rivera O, Falcon C, Rami L, Sánchez-Valle R, Lladó A, Gispert JD, Molinuevo JL, for the Alzheimer’s Disease Neuroimaging Initiative
Structural connectivity alterations along the AD continuum: reproducibility across two independent samples and correlation with CSF Aβ and tau
Journal of Alzheimer's DiseaseAbstractBackground: Gray matter changes associated with the progression of Alzheimer's disease (AD) have been thoroughly studied. However, alterations in white matter tracts have received less attention...
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Brugulat-Serrat A, Rojas S, Bargalló N, Conesa G, Minguillón C, Fauria K, Gramunt, Molinuevo JL, Gispert JD
Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project
BMJ OpenAbstractObjectives: To describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer's disease (AD). Design: Cross...
