Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Van Waalwijk van Doorn LJ, Gispert JD, Kuiperij HB AK, Yener G, Molinuevo JL, Verbeek MM
Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
Journal of Alzheimer's DiseaseAbstractCerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., Aβ42, total tau (t-tau), and...
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Gispert JD, Monté GC, Suárez-Calvet M, Falcon C, Tucholka A, Rojas S, Rami L, Sánchez-Valle R, Lladó A, Kleinberger G, Haass C, Molinuevo JL
The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
Alzheimer's & Dementia: Diagnosis, Assessment & Disease MonitoringAbstractIntroduction: Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal...
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Gispert JD, Suárez-Calvet M, Monté GC, Tucholka A, Falcon C, Rojas S, Rami L, Sanchez-Valle, R, Llado A, Kleinberger G, Haass C, Molinuevo JL
Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
Alzheimer's & DementiaAbstractIntroduction: TREM2 is involved in the regulation of inflammatory response and phagocytosis. A soluble fragment (sTREM2) is often found abnormally increased in cerebrospinal fluid (CSF) in Alzheimer's...
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Modeling practice effects in healthy middle-aged participants of the Alzheimer and Families parent cohort
Alzheimer's & Dementia: Diagnosis, Assessment & Disease MonitoringAbstractIntroduction: Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a...
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Molinuevo JL, Gramunt N, Gispert JD, Fauria K, Esteller M, Minguillon C, Sánchez-Benavides G, Huesa G, Morán S, Camí J.
The ALFA project: a research platform to identify early pathophysiological features of Alzheimer’s disease
Alzheimer's & Dementia: Translational Research & Clinical InterventionsAbstractIntroduction: The preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project...
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Gramunt N, Sánchez-Benavides G, Buschke H, Dieguez-Vide F, Pena-Casanova J, Masramon X, Fauria K, Gispert JD, Molinuevo JL
The Memory Binding Test: Development of Two Alternate Forms into Spanish and Catalan
Journal of Alzheimer's DiseaseAbstractBackground: The Memory Binding Test (MBT) is emerging as a promising tool for the detection of subtle memory impairment suggestive of Alzheimer's disease (AD). For such a test to be widely accessed...
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Gramunt N, Sánchez-Benavides G, Buschke H, Lipton RB, Masramon X, Gispert JD, Pena-Casanova J, Fauria K, Molinuevo JL
Psychometric Properties of the Memory Binding Test: Test-Retest Reliability and Convergent Validity
Journal of Alzheimer's DiseaseAbstractBackground: Episodic memory testing is fundamental for the diagnosis of Alzheimer's disease (AD). Although the Free and Cued Selective Reminding Test (FCSRT) is widely used for this purpose, it may...
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Gramunt N, Buschke H, Sánchez-Benavides G, Lipton RB, Pena-Casanova J, Dieguez-Vide F, Masramon X, Gispert JD, Fauria K, Cami J, Molinuevo JL
Reference Data of the Spanish Memory Binding Test in a Midlife Population from the ALFA STUDY (Alzheimer's and Family)
Journal of Alzheimer's DiseaseAbstractBackground: The Memory Binding Test (MBT) is a novel test based on the learning of two lists of words, developed to detect early memory impairment suggestive of Alzheimer's disease (AD). Objective: To...
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Popota FD, Aguiar P, España S, Lois C, Udias JM, Ros D, Pavia J, Gispert JD
Monte Carlo simulations versus experimental measurements in a small animal PET system. A comparison in the NEMA NU 4-2008 framework
Physics in Medicine & BiologyAbstractIn this work a comparison between experimental and simulated data using GATE and PeneloPET Monte Carlo simulation packages is presented. All simulated setups, as well as the experimental measurements...
