Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Toccaceli Blasi M, Salzillo M, Buscarnera S, Nuti F, Stanziale C, Pecorari C, Ottone DA, Salati E, D'Antonio F, Canevelli M, Bruno G.
A diary-based approach to improve neuropsychiatric symptom assessment in dementia: A cross-sectional comparison with the neuropsychiatric inventory
Journal of Alzheimer's DiseaseAbstractBackgroundNeuropsychiatric symptoms (NPS) are among the most challenging manifestations of dementia. Currently available assessment tools often fail to fully capture their complexity. Thus, novel...
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Shekari M, Escalante AG, Milà-Alomà M, Falcon C, López-Martos D, Sánchez-Benavides G, Brugulat-Serrat A, Niñerola-Baizán A, Ashton NJ, Karikari TK, Lantero-Rodriguez J, Montoliu-Gaya L, Snellman A, Day TA, Dage JL, Ortiz-Romero P, Tonietto M, Borroni E, Klein G, Kollmorgen G, Carboni M, Quijano-Rubio C, Vanmechelen E, Minguillón C, Fauria K, Perissinotti A, Molinuevo JL, Zetterberg H, Blennow K, Grau-Rivera O, Suárez-Calvet M, Gispert JD; ALFA Study.
Associations of 18F-RO-948 tau PET with fluid AD biomarkers, Centiloid, and cognition in early AD continuum
Alzheimer's & DementiaAbstractIntroduction: We examined neurofibrillary tangle (NFT) pathology using 18F-RO-948 tau positron emission tomography (PET) in cognitively unimpaired individuals and its associations with amyloid plaques...
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Hortsch S, Domenico AD, Borlinghaus N, Caley D, Kaminioti-Dumont L, Jeppesen SB, González-Escalante A, Ritchie C, Frederiksen KS, Suárez-Calvet M.
Performance of a fully automated plasma tau phosphorylated at threonine 217 immunoassay to reflect amyloid-beta burden in an unselected cohort representative of clinical practice
The journal of prevention of Alzheimer's DiseaseAbstractBackground: With the emergence of disease-modifying anti-amyloid-beta (Aβ) therapies for Alzheimer's disease (AD), early and accurate quantitative measures of Aβ burden are critical. Blood-based...
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Reiman EM, Alexander RC, Langbaum JB, Aisen PS, Ashton N, Atri A, Barbarino P, Byrd GS, Feldman HH, Fowler NR, Ghisays V, Grill JD, Hassenstab J, Heaton GR, Herring WL, Jack CR Jr, Johnson SC, Karlawish J, Keach NL, Kivipelto M, Krumholz HM, Largent EA, MaGee-Rodgers T, McDade E, Mielke MM, Molina-Henry D, Petersen RC, Rabinovici GD, Ritchie C, Schindler SE, Sperling RA, Suárez-Calvet M, Vradenburg G, Weiner MW, Welsh-Bohmer KA, Zetterberg H, Zuendel MT, Mattke S, Cummings JL
A path to preventing cognitive impairment due to Alzheimer's disease: initiatives beginning in the USA
The Lancet NeurologyAbstractAntibody therapies can remove amyloid plaques from the brain and slow cognitive decline in people with Alzheimer's disease who are mildly impaired. These drugs are now being evaluated in participants...
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Timsina J, Jiang C, McCartney DL, Tao F, Dalmasso MC, Najar J, Anastasi F, Ohlei O, Puerta Fuentes R, Yang C, Bradley J, Western D, Ali M, Wang C, Yang C, Wu Y, Liu M, Budde J, Williams J, Mahoney R, Castillo Morales A, Hohman TJ, Dumitrescu L, Wang TC, Tesi N, Kern S, Waern M, Skoog I, van Harten A, Pijnenburg YAL, van der Flier WM, Sánchez-Juan P, Rodriguez-Rodriguez E, Kleineidam L, Peters O, Schneider A, Küçükali F, Bellenguez C, Grenier-Boley B, Heikkinen S, de Rojas I, Rujescu D, Scherbaum N, Hausner L, Düzel E, Grimmer T, Wiltfang J, Vandenberghe R, Engelborghs S, Heilmann-Heimbach S, Schmid M, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, Pérez-Tur J, Bullido MJ, Sánchez-Valle R, Álvarez V, García-González P, Mir P, Real LM, Piñol-Ripoll G, García-Alberca JM, Seelaar H, Ramakers I, Papma J, Hulsman M, Laske C, Teipel S, Priller J, Perneczky R, Buerger K, Nöthen MM, Lewczuk P, Kornhuber J, Hampel H, Giegling I, Goldhardt O, Diehl-Schmid J, Andrade V, Heneka MM, Frölich L, Vogelgsang J, Graff C, Thonberg H, Ullgren A, Papenberg G, Deleuze JF, Dufouil C, Wagner M, Jessen F, Holstege H, van Duijn C, Lebouvier T, Hannon O, Leinonen V, Soininen H, Herukka SK, Giedraitis V, Löwenmark M, Kilander L, Genius P, Rodríguez B, Luckett ES, Navarro A, Cano A, Marquié M, Blennow K, Zetterberg H, Lleo A, Boada M, Ruiz A, Lee VM, Van Deerlin VM, Deming Y, Johnson SC, Engelman CD, Pastor P, Alvarez I, Peskind ER, Heslegrave AJ, Saykin AJ, Nho K, Schindler SE, Morris JC, Holtzman DM, McDade E, Renton AE, Goate A, Ibanez L, Riemenschneider M, Albert MS, Laws SM, Porter T, O'Brien EK, Shaw LM, Tijms BM, Ingelsson M, Visser PJ, Hiltunen M, Sleegers K, Ritchie CW, Sims R, Belloy M, Lambert JC, Vilor-Tejedor N, Fernández MV, Li QS, Nagle MW, Marioni RE, Ramirez A, Bertram L, van der Lee SJ, Cruchaga C.
GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy
Nature CommunicationsAbstractCerebrospinal fluid amyloid beta 42, total tau, and phosphorylated tau 181 are well accepted markers of Alzheimer's disease. These biomarkers better reflect disease pathogenesis compared to clinical...
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Kassinopoulos M, Montesinos P, Falcon C, Huguet J, Minguillon C, Fauria K, Kollmorgen G, Quijano-Rubio C, Molinuevo JL, Grau-Rivera O, Zetterberg H, Blennow K, Suárez-Calvet M, Sanchez-Gonzalez J, Gispert JD; ALFA study
Intracellular fluid accumulation underlies brain volume increases in early Alzheimer's disease
Brain CommunicationsAbstractIn the preclinical stages of Alzheimer's disease, increased brain volume has been associated with amyloid-beta pathology, particularly in regions that undergo volume reductions as the disease...
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Genius P, Fernández-Bonet A, Rodríguez-Fernández B, Gallay C, Gonzalez-Escalante A, Sánchez-Benavides G, López-Martos D, Esteller M, Navarro A, Gispert JD, Brugulat-Serrat A, Vilor-Tejedor N
Sex-specific early cognitive changes are linked to global and pathway-specific genetic risk for Alzheimer's disease in at-risk individuals
Biology of sex differencesAbstractAlzheimer's disease (AD) is a progressive neurodegenerative condition in which genetic predisposition plays a key role, yet the sex-specific mechanisms linking genetic risk to early cognitive changes...
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Caviedes A, Cabral-Miranda F, Orellana P, Hernández H, Henríquez F, Gonzalez-Gomez R, Pizarro M, Migeot J, Ochoa-Rosales C, Gonzalez-Silva C, Marin-Diaz N, Coronel-Oliveros C, Santamaría-García H, Carmona D, García AM, Slachevsky A, Singleton A, Qi AY, Lawlor B, Miller B, Dhooge C, Pantazis C, Udeh-Momoh CT, Aguillón D, Matallana DL, Zimmer ER, Resende EPF, Farina FR, Cabello F, Lopera F, Zetterberg H, Avila-Funes JA, Acosta-Uribe J, Possin KL, Kosik KS, Hu K, Takada LT, de Oliveira MO, Maito MA, Suárez-Calvet M, Godoy ME, Behrens MI, Parra MA, Del Campo M, Bruno M, Gelvez N, Pozo-Castro N, Cochran JN, Custodio N, Ortega R, Santibanez R, de la Cruz R, Montesinos R, McDonagh S, Bandres-Ciga S, Javandel S, Brucki SMD, Pina-Escudero SD, Valcour V, Li Z, Yokoyama JS, Ibañez A, Duran-Aniotz C;
Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America
Nature AgingAbstractDementia diagnosis increasingly relies on blood-based biomarkers, yet their performance in diverse populations remains insufficiently characterized. Latin America, with substantial genetic and...
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Suárez-Calvet M, Abdelnour C, Alcolea D, Mendióroz-Iriarte M, Balasa M, Morenas-Rodríguez E, Puig-Pijoan A, Sánchez-Juan P, Villarejo A, Sánchez-Valle R; por el Grupo de trabajo en biomarcadores en sangre del Grupo de Estudio de Conducta y Demencias de la Sociedad Española de Neurología.
Blood-based Biomarkers for Alzheimer's Disease: Positioning Document and Usage Recommendations from the Behavioral Neurology and Dementia Study Group of the Spanish Society of Neurology
NeurologíaAbstractIntroduction: The development of blood biomarkers for detecting Alzheimer's disease (AD) represents one of the most significant recent advances, and some are already available for clinical practice...
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Imam F, Saloner R, Vogel JW, Krish V, Abdel-Azim G, Ali M, An L, Anastasi F, Bennett D, Pichet Binette A, Boxer AL, Bringmann M, Burns JM, Cruchaga C, Dage JL, Farinas A, Ferrucci L, Finney CA, Frasier M, Hansson O, Hohman TJ, Johnson ECB, Kivimaki M, Korologou-Linden R, Ruiz Laza A, Levey AI, Liepelt-Scarfone I, Lu L, Mattsson-Carlgren N, Middleton LT, Nho K, Oh HS, Petersen RC, Reiman EM, Robinson O, Rothstein JD, Saykin AJ, Shvetcov A, Slawson C, Smets B, Suárez-Calvet M, Tijms BM, Timmers M, Vieira F, Vilor-Tejedor N, Visser PJ, Walker KA, Winchester LM, Wyss-Coray T, Yang C, Bose N, Lovestone S
The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging
Nature MedicineAbstractMore than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment...
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