News:Research and scientific results

Fluid biomarkers remain highly valuable but are not yet sensitive enough to detect the earliest tau changes.

An international study involving data from the ALFA+ cohort shows that the combination of physical and social environmental exposures is a major driver of accelerated or delayed brain aging.

A study by the BBRC shows that the genetic risk of Alzheimer’s disease may manifest itself differently in women and men, paving the way for more personalised prevention strategies.

The study strengthens the validity of blood-based biomarkers for detecting Alzheimer’s disease and other dementias in diverse population settings, representing a key step towards more accessible and equitable diagnosis

This research describes new mechanisms linking the locus coeruleus to deep sleep and reveals differences according to sex and cerebral vascular status.

The study analysed 1147 lumbar punctures performed on 724 participants in the ALFA study

The book is leading reference on biomarkers shaping diagnosis, prognosis, and therapy development in Alzheimer’s disease and related dementias.

These findings reinforce the robustness of current CSF tools for early detection while encouraging sex-aware interpretation when tracking disease biology over time

The international study shows that this biomarker allows detection of the presence of amyloid beta deposits, a key pathology in the development of the disease, in individuals without cognitive impairment