Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Cacciaglia R, Molinuevo JL, Falcón C, Brugulat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillon C, Fauria K, Gispert JD
Impact of APOE genetic variant on brain morphology in a cohort of cognitively healthy middle-aged individuals with enriched genetic risk for Alzheimer’s disease
Alzheimer's DementiaAbstractIntroduction: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains...
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Cacciaglia R, Molinuevo JL, Sánchez-Benavides G, Falcon C, Gramunt N, Brugulat-Serrat A, Grau-Rivera O, Gispert JD
Episodic Memory and Executive Function in cognitively Healthy Individuals Display Distinct Neuroanatomical Correlates which are Differentially Modulated by Aging
Human Brain MappingAbstractThe neuroanatomical bases of episodic memory (EM) and executive functions (EFs) have been widely addressed in patients with brain damage and in individuals with neurologic disorders. These studies...
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Cacciaglia R, Molinuevo JL, Falcón C, Brugulat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillon C, Fauria K, Gispert JD
Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease
Alzheimer's & DementiaAbstractIntroduction: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains...
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Operto G, Cacciaglia R, Grau O, Falcón C, Brugulat-Serrat A, Ródenas P, Ramos R, Morán S, Esteller M, Bargalló N, Molinuevo JL, Gispert JD
White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes
Alzheimer's Research & TherapyAbstractBackground: The ε4 allele of the apolipoprotein E gene (APOE-ε4) is the strongest genetic factor for late-onset Alzheimer's disease. During middle age, cognitively healthy APOE-ε4 carriers already...
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Grau-Guinea L, Pérez-Enríquez C, García-Escobar G, Arrondo-Elizarán C, Pereira-Cutiño B, Florido-Santiago M, Piqué-Candini J, Planas A, Paez M, Peña-Casanova J, Sánchez-Benavides G
Development, equivalence study, and normative data of version B of the Spanish-language Free and Cued Selective Reminding Test
NeurologíaAbstractIntroduction: The Free and Cued Selective Reminding Test (FCSRT) is widely used for the assessment of verbal episodic memory, mainly in patients with Alzheimer disease. A Spanish version of the FCSRT...
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Gascon M, Sánchez-Benavides G, Dadvand P, Martínez D, Gramunt N, Gotsens X, Cirach M, Vert C, Molinuevo JL, Nieuwenhuijsen M
Long-term exposure to residential green and blue spaces and anxiety and depression in adults: A cross-sectional study
Environmental ResearchAbstractBackground: Although exposure to natural outdoor environments has been consistently associated with improved perceived general health, available evidence on a protective association between this...
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Rojas S, Brugulat-Serrat A, Bargalló N, Minguillón C, Tucholka A, Falcon C, Carvalho A, Morán S, Esteller M, Gramunt N, Fauria K, Camí J, Molinuevo JL, Gispert JD
Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45-75: Results from the ALFA study
Journal of Cerebral Blood Flow & MetabolismAbstractCerebral white matter hyperintensities are believed the consequence of small vessel disease and are associated with risk and progression of Alzheimer's disease. The ɛ4 allele of the APOE gene is the...
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Tucholka A, Grau-Rivera O, Falcon C, Rami L, Sánchez-Valle R, Lladó A, Gispert JD, Molinuevo JL, for the Alzheimer’s Disease Neuroimaging Initiative
Structural connectivity alterations along the AD continuum: reproducibility across two independent samples and correlation with CSF Aβ and tau
Journal of Alzheimer's DiseaseAbstractBackground: Gray matter changes associated with the progression of Alzheimer's disease (AD) have been thoroughly studied. However, alterations in white matter tracts have received less attention...
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Vert C, Sánchez-Benavides G, Martínez D, Gotsens X, Gramunt N, Cirach M, Molinuevo JL, Sunyer J, Nieuwenhuijsen MJ, Gascon M
Effect of long-term exposure to air pollution on anxiety and depression in adults: A cross-sectional study
International Journal of Hygiene and Environmental HealthAbstractBackground: The association between exposure to air pollutants and mental disorders among adults has been suggested, although results are not consistent. Objective: To analyze the association between...
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Modeling practice effects in healthy middle-aged participants of the Alzheimer and Families parent cohort
Alzheimer's & Dementia: Diagnosis, Assessment & Disease MonitoringAbstractIntroduction: Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a...
