Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Cacciaglia R , Molinuevo JL , Falcón C , Arenaza-Urquijo EM , Sánchez-Benavides G , Brugulat-Serrat A, Blennow K, Gispert JD
APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks
Cereb CortexAbstractGray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the...
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Jecmenica Lukic M, Kurz C, Respondek G, Grau-Rivera O , Compta Y, Gelpi E, Troakes C; Barcelona Brain Bank collaborative group, the MDS-endorsed PSP study group, van Swieten JC, Giese A, Roeber S, Arzberger T, Höglinger G.
Copathology in Progressive Supranuclear Palsy: Does It Matter?
Mov DisordAbstractBackground: The influence of concomitant brain pathologies on the progression rate in PSP is unclear. Objectives: To analyze the frequency and severity of copathologies and their impact on the...
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Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, José L Molinuevo, ALFA Study
Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal down-regulation
BrainAbstractResearch into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological continuum of Alzheimer's disease. In...
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Skouras S, Torner J, Andersson P, Koush Y, Falcon C, Minguillon C, Fauria K, Alpiste F, Blenow K, Zetterberg H, Gispert JD, Molinuevo JL
Earliest Amyloid and Tau Deposition Modulate the Influence of Limbic Networks During Closed-Loop Hippocampal Downregulation
BrainAbstractResearch into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological continuum of Alzheimer's disease. In... -
Shared Latent Structures Between Imaging Features and Biomarkers in Early Stages of Alzheimer's Disease: A Predictive Study
IEEE J Biomed Health InformAbstractMagnetic resonance imaging (MRI) provides high resolution brain morphological information and is used as a biomarker in neurodegenerative diseases. Population studies of brain morphology often seek to... -
Vilor-Tejedor N , Ikram MA, Roshchupkin GV, Cáceres A, Alemany S, Vernooij MW, Niessen WJ, van Duijn CM, Sunyer J, Adams HH, González JR
Independent Multiple Factor Association Analysis for Multiblock Data in Imaging Genetics
NeuroinformaticsAbstractMultivariate methods have the potential to better capture complex relationships that may exist between different biological levels. Multiple Factor Analysis (MFA) is one of the most popular methods to...
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Westwood S, Baird AL, Anand SN, Nevado-Holgado AJ, Kormilitzin A, Shi L, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Baker S, Buckley NJ, Ten Kate M, Scheltens P, Molinuevo JL, Rami L, Wallin A, Visser PJ, Lovestone S, et al
Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort
J Alzheimers DisAbstractWe have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD... -
Jessen F, Amariglio RE, Buckley RF, van der Flier WM, Han Y, Molinuevo JL, Rabin L, Rentz DM, Rodriguez-Gomez O, Saykin AJ, Sikkes SAM, Smart CM, Wolfsgruber S, Wagner M
The Characterisation of Subjective Cognitive Decline
The Lancet NeurologyAbstractA growing awareness about brain health and Alzheimer's disease in the general population is leading to an increasing number of cognitively unimpaired individuals, who are concerned that they have... -
Grau-Rivera O, Operto G, Falcón C, Sánchez-Benavides G, Cacciaglia R, Brugulat-Serrat A, Gramunt N, Salvadó G, Suárez-Calvet M, Minguillon C, Iranzo Á, Gispert JD, Molinuevo JL, ALFA Study
Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
Alzheimer's Research & TherapyAbstractBackground: Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study...
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Vermunt L, Muniz-Terrera G, Ter Meulen L, Veal C, Blennow K, Campbell A, Carrié I, Delrieu J, Fauria K, Huesa Rodríguez G, Ingala S, Jenkins N, Molinuevo JL, Ousset PJ, Porteous D, Prins ND, Solomon A, Tom BD, Zetterberg H, Zwan M, Ritchie CW, Scheltens P, Luscan G, Brookes AJ, Visser PJ; IMI-EPAD collaborators
Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings
Alzheimer's Research & TherapyAbstractBackground: Recruitment is often a bottleneck in secondary prevention trials in Alzheimer disease (AD). Furthermore, screen-failure rates in these trials are typically high due to relatively low...
