Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Milà-Alomà M, Salvadó G, Gispert JD, Vilor-Tejedor N, Grau-Rivera O, Sala-Vila A, Sánchez-Benavides G, Arenaza-Urquijo EM, Crous-Bou M, González-de-Echávarri JM, Minguillon C, Fauria K, Simon M, Kollmorgen G, Zetterberg H, Blennow K, Suárez-Calvet M, Molinuevo JL; ALFA study
Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
Alzheimer's DementiaAbstractIntroduction: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood.
Methods: We used NeuroToolKit and Elecsys® immunoassays to measure...
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Carles Falcon, Oriol Grau-Rivera, Marc Suárez-Calvet, Beatriz Bosch, Raquel Sánchez-Valle, Eider M Arenaza-Urquijo, José María González-de-Echavarri, Juan Domingo Gispert, Lorena Rami, José Luis Molinuevo
Sex differences of longitudinal brain changes in cognitively unimpaired adults
Journal of Alzheimer's DiseaseAbstractBackground: There is increasing evidence that AD progression differs by sex.
Objective: The aim of this work was to determine sex differences in the association of baseline levels of cerebrospinal...
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Natalia Vilor-Tejedor, Grégory Operto, Tavia E Evans, Carles Falcon, Marta Crous-Bou, Carolina Minguillón, Raffaele Cacciaglia, Marta Milà-Alomà, Oriol Grau-Rivera, Marc Suárez-Calvet, Diego Garrido-Martín, Sebastián Morán, Manel Esteller, Hieab H Adams, José Luis Molinuevo, Roderic Guigó, Juan Domingo Gispert, ALFA Study
Effect of BDNF Val66Met Polymorphism on Hippocampal Subfield Volumes and Compensatory Interaction with APOE-ε4
Brain Structure and FunctionAbstractBackground: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous...
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Silvia Ingala, Linda Mazzai, Carole H Sudre, Gemma Salvadó, Anna Brugulat-Serrat, Viktor Wottschel, Carles Falcon, Grégory Operto, Betty Tijms, Juan Domingo Gispert, José Luis Molinuevo, Frederik Barkhof, ALFA Study
The relation between APOE genotype and cerebral microbleeds in a cognitively unimpaired middle- and late-aged individuals
Neurobiology of AgingAbstractPositive associations between cerebral microbleeds (CMBs) and APOE-ε4 (apolipoprotein E) genotype have been reported in Alzheimer's disease, but show conflicting results. We investigated the effect of...
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Raffaele Cacciaglia, José Luis Molinuevo, Carles Falcón, Eider M Arenaza-Urquijo, Gonzalo Sánchez-Benavides, Anna Brugulat-Serrat, Kaj Blennow, Henrik Zetterberg, Juan Domingo Gispert, ALFA study
APOE-e4 shapes the cerebral organization in cognitively intact individuals as reflected by structural gray matter networks
Cerebral CortexAbstractGray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the...
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Crous-Bou M, Gascon M, Gispert JD, Cirach M, Sánchez-Benavides G, Falcon C, Arenaza-Urquijo EM, Gotsens X, Fauria K, Sunyer J, Nieuwenhuijsen MJ, Molinuevo JL
Impact of Urban Environmental Exposures on Cognitive Performance and Brain Structure of Healthy Individuals at Risk for Alzheimer's Dementia
Environ IntAbstractBackground: Air quality might contribute to incidence of dementia-related disorders, including Alzheimer's dementia (AD). The aim of our study is to evaluate the effect of urban environmental...
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Cacciaglia R , Molinuevo JL , Falcón C , Arenaza-Urquijo EM , Sánchez-Benavides G , Brugulat-Serrat A, Blennow K, Gispert JD
APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks
Cereb CortexAbstractGray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the...
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Jecmenica Lukic M, Kurz C, Respondek G, Grau-Rivera O , Compta Y, Gelpi E, Troakes C; Barcelona Brain Bank collaborative group, the MDS-endorsed PSP study group, van Swieten JC, Giese A, Roeber S, Arzberger T, Höglinger G.
Copathology in Progressive Supranuclear Palsy: Does It Matter?
Mov DisordAbstractBackground: The influence of concomitant brain pathologies on the progression rate in PSP is unclear. Objectives: To analyze the frequency and severity of copathologies and their impact on the...
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Grau-Rivera O, Operto G, Falcón C, Sánchez-Benavides G, Cacciaglia R, Brugulat-Serrat A, Gramunt N, Salvadó G, Suárez-Calvet M, Minguillon C, Iranzo Á, Gispert JD, Molinuevo JL, ALFA Study
Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
Alzheimer's Research & TherapyAbstractBackground: Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study...
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Brugulat-Serrat A, Salvadó G, Operto G, Cacciaglia R, Sudre CH, Grau-Rivera O, Suárez-Calvet M, Falcon C, Sánchez-Benavides G, Gramunt N, Minguillon C, Fauria K, Barkhof F, Molinuevo JL, Gispert JD, ALFA Study
White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
Human Brain MappingAbstractWhite matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume...
