Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
Orellana P, Caviedes A, Gonzalez L, Ochoa-Rosales C, Carmona D, González-Silva C, Hernández H, Britton GB, Villarreal AE, Campos V, Hendrie H, Acosta-Uribe J, Pina-Escudero SD, Yokoyama JS, Vilor-Tejedor N, Parra M, Santamaria-García H, Ibañez A, de la Cruz R, Duran-Aniotz C
The apolipoprotein E (APOE) ε4 allele represents the strongest genetic risk factor for Alzheimer's disease (AD), but its role in genetically diverse Latin American and Caribbean (LAC) populations is...
Brugulat-Serrat A, Tsoy E, Sánchez-Benavides G, Milà-Alomà M, Gaynor LS, Grau-Rivera O, Gispert JD, Kramer JH, Possin KL
Introduction: Sensitive memory paradigms may allow the detection of subtle memory changes associated with early Alzheimer's pathology in individuals without established clinical symptomatology.
Methods...
Falgàs N, Tort-Colet N, Martín-Sobrino I, Mayà G, Peña-González M, Rudilosso S, Gaig C, Bosch B, Arqueros A, Pérez-Millan A, Tort-Merino A, Fernández-Villullas G, Piñol-Ripoll G, Balasa M, Lladó A, Ruiz MM, Muñoz-Moreno E, Grau-Rivera O, Iranzo A, Grinberg LT, Sánchez-Valle R.
Introduction: Sleep disruption, particularly loss of slow-wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus...
Genius P, Fernández-Bonet A, Rodríguez-Fernández B, Gallay C, Gonzalez-Escalante A, Sánchez-Benavides G, López-Martos D, Esteller M, Navarro A, Gispert JD, Brugulat-Serrat A, Vilor-Tejedor N
Alzheimer's disease (AD) is a progressive neurodegenerative condition in which genetic predisposition plays a key role, yet the sex-specific mechanisms linking genetic risk to early cognitive changes...
Bolsewig K, Bellomo G, Hok-A-Hin YS, Al Idrissi I, Vermunt L, Lleó A, Alcolea D, Sieben A, Engelborghs S, Simonsen AH, Hasselbalch SG, Bech S, Morrema THJ, Hoozemans JJM, Bol JGJM, van Alphen J, Gaetani L, Chiasserini D, Paolini Paoletti F, Parnetti L, Kang S, Lee YG, Jeon S, Lee A, Jeon S, Ye BS, Del Campo Milán M, van der Flier WM, van de Berg WDJ, Lemstra AW, Willemse EAJ, Teunissen CE
Accurate diagnosis of dementia with Lewy bodies (DLB) remains challenging, with misdiagnosis potentially leading to harmful treatment decisions. DOPA decarboxylase (DDC) shows promise as a...
Orellana P, Henríquez F, Cabral-Miranda F, Hernandez H, Ferreira PCL, Bellaver B, Caviedes A, Pizarro M, Gonzalez-Silva C, Marin-Diaz N, Riquelme P, Pozo N, Damm F, Court FA, Gonzalez-Billault C, Lillo P, Thumala-Dockendorff D, Cerda M, Villagra R, de la Cruz R, K Karikari T, Ibañez A, Zetterberg H, A Pascoal T, Duran-Aniotz C, Slachevsky A.
Background: Plasma biomarkers have emerged as robust indicators of Alzheimer's disease (AD) pathology, offering accessible tools for staging and stratification. However, their expression across...
Caviedes A, Cabral-Miranda F, Orellana P, Hernández H, Henríquez F, Gonzalez-Gomez R, Pizarro M, Migeot J, Ochoa-Rosales C, Gonzalez-Silva C, Marin-Diaz N, Coronel-Oliveros C, Santamaría-García H, Carmona D, García AM, Slachevsky A, Singleton A, Qi AY, Lawlor B, Miller B, Dhooge C, Pantazis C, Udeh-Momoh CT, Aguillón D, Matallana DL, Zimmer ER, Resende EPF, Farina FR, Cabello F, Lopera F, Zetterberg H, Avila-Funes JA, Acosta-Uribe J, Possin KL, Kosik KS, Hu K, Takada LT, de Oliveira MO, Maito MA, Suárez-Calvet M, Godoy ME, Behrens MI, Parra MA, Del Campo M, Bruno M, Gelvez N, Pozo-Castro N, Cochran JN, Custodio N, Ortega R, Santibanez R, de la Cruz R, Montesinos R, McDonagh S, Bandres-Ciga S, Javandel S, Brucki SMD, Pina-Escudero SD, Valcour V, Li Z, Yokoyama JS, Ibañez A, Duran-Aniotz C;
Dementia diagnosis increasingly relies on blood-based biomarkers, yet their performance in diverse populations remains insufficiently characterized. Latin America, with substantial genetic and...
Hok-A-Hin YS, Bongers B, Bolsewig K, Boonkamp L, Ruiters DN, Lemstra AW, van der Flier WM, Pijnenburg YAL, Del Campo M, Teunissen CE
Background: Using proximity extension proteomic arrays (PEA), we previously identified a nine-biomarker CSF protein panel reflecting different biological processes dysregulated in Alzheimer´s disease...
Gonzalez-Gomez R, Demnitz N, Coronel C, Gates AT, Kjaer M, Siebner HR, Boraxbekk CJ, Ibanez AM
Exercise improves cognition, mental wellbeing, and protects against neurodegeneration. However, most prior neuroscience studies have focused on localized brain changes without quantifying their impact...
Álvarez-Bustos A, Andres-Lacueva C, Ara I, Arévalo MA, Bolaños JP, Coto-Montes A, Enriquez JA, Escames G, García-García FJ, Gómez-Cabrera MC, Grau-Rivera O, Izquierdo M, Martínez Velilla N, Matheu A, Menéndez Colino R, Muñoz Torres M, Nogués X, Oliva J, Orts-Cortés MI, Párraga Martínez I, Priego F, Rabassa-Bonet M, Rol MÁ, Serra-Rexach JA, Tarazona-Santabalbina FJ, Rodríguez-Mañas L, Abizanda P
Background: The lack of a universally accepted definition, a gold-standard assessment tool, and sufficient evidence-based interventions has hindered the integration of frailty into routine clinical...