Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Vilor-Tejedor N , Alemany S, Cáceres A, Bustamante M, Mortamais M, Pujol J, Sunyer J, González JRSparse multiple factor analysis to integrate genetic data, neuroimaging features, and attention-deficit/hyperactivity disorder domains
International Journal of Methods in Psychiatric ResearchAbstractObjectives: We proposed the application of a multivariate cross-sectional framework based on a combination of a variable selection method and a multiple factor analysis (MFA) in order to identify... -
Sánchez-Benavides G, Grau-Rivera O, Cacciaglia R, Suárez-Calvet M, Falcon C, Minguillón C, Gramunt N, Gispert JD, Molinuevo JL
Distinct Cognitive and Brain Morphological Features in Healthy Subjects Unaware of Informant-Reported Cognitive Decline
Journal of Alzheimer's DiseaseAbstractBackground: Subtle cognitive decline preceding cognitive impairment can be self-perceived, referred to as subjective cognitive decline (SCD), or go unrecognized. Objective: To study the clinical...
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Harrington LB, Hagan KA, Mukamal KJ, Kang JH, Kim J, Crous-Bou M, Lindström S, Rimm EB, Kabrhel C, Jensen MK
Alcohol consumption and the risk of incident pulmonary embolism in US women and men
Journal of Thrombosis and HaemostasisAbstractEssentials The association of moderate alcohol consumption with pulmonary embolism (PE) risk remains unclear. In three large US cohorts, we evaluated the association of alcohol consumption with PE... -
Cacciaglia R, Molinuevo JL, Falcón C, Brugulat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillon C, Fauria K, Gispert JD
Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease
Alzheimer's & DementiaAbstractIntroduction: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains...
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Cacciaglia R, Molinuevo JL, Sánchez-Benavides G, Falcon C, Gramunt N, Brugulat-Serrat A, Grau-Rivera O, Gispert JD
Episodic Memory and Executive Function in cognitively Healthy Individuals Display Distinct Neuroanatomical Correlates which are Differentially Modulated by Aging
Human Brain MappingAbstractThe neuroanatomical bases of episodic memory (EM) and executive functions (EFs) have been widely addressed in patients with brain damage and in individuals with neurologic disorders. These studies...
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Cacciaglia R, Molinuevo JL, Falcón C, Brugulat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillon C, Fauria K, Gispert JD
Impact of APOE genetic variant on brain morphology in a cohort of cognitively healthy middle-aged individuals with enriched genetic risk for Alzheimer’s disease
Alzheimer's DementiaAbstractIntroduction: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains...
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Casamitjana A, Petrone P, Tucholka A, Falcon C, Skouras S, Molinuevo JL, Vilaplana V, Gispert JD, for the Alzheimer's Disease Neuroimaging Initiative
MRI-Based Screening of Preclinical Alzheimer’s Disease for Prevention Clinical Trials
Journal of Alzheimer's DiseaseAbstractThe identification of healthy individuals harboring amyloid pathology represents one important challenge for secondary prevention clinical trials in Alzheimer's disease (AD). Consequently, noninvasive...
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Bos I, Vos S, Vandenberghe R, Scheltens P, Engelborghs S, Frisoni G, Molinuevo JL, Wallin A, Lleó A, Popp J, Martinez-Lage P, Baird A, Dobson R, Legido-Quigley C, Sleegers K, Van Broeckhoven C, Bertram L, Ten Kate M, Barkhof F, Zetterberg H, Lovestone S, Streffer J, Visser PJ
The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics
Alzheimer's Research & TherapyAbstractBackground: There is an urgent need for novel, noninvasive biomarkers to diagnose Alzheimer's disease (AD) in the predementia stages and to predict the rate of decline. Therefore, we set up the... -
Ghaziri J, Tucholka A, Girard G, Boucher O, Houde JC, Descoteaux M, Obaid S, Gilbert G, Rouleau I, Nguyen DK
Subcortical structural connectivity of insular subregions
Scientific ReportsAbstractHidden beneath the Sylvian fissure and sometimes considered as the fifth lobe of the brain, the insula plays a multi-modal role from its strategic location. Previous structural studies have reported... -
Hansson O, Mikulskis A, Fagan AM, Teunissen C, Zetterberg H, Vanderstichele H, Molinuevo JL, Shaw LM, Vandijck M, Verbeek MM, Savage M, Mattsson N, Lewczuk P, Batrla R, Rutz S, Dean RA, Blennow K
The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: A review
Alzheimer's DementiaAbstractIntroduction: Cerebrospinal fluid (CSF) biomarkers have the potential to improve the diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical CSF handling protocols...
